Literature DB >> 3335036

Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell.

J A McBain1, G R Pettit, G C Mueller.   

Abstract

12-O-Tetradecanoylphorbol-13-acetate (TPA), a highly active representative of the tumor-promoting phorbol esters, induces a rapid terminal differentiation of a human colon cancer cell line. Bryostatin 1, a macrocyclic lactone, completely counteracts this effect of TPA and promotes continued replication. The observed responses provide a system for identifying cellular processes which are involved in the induced terminal differentiation of human colon cancer cells.

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Year:  1988        PMID： 3335036     DOI： 10.1093/carcin/9.1.123

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  7 in total

1.  Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity.

Authors:  Z T Han; X X Zhu; R Y Yang; J Z Sun; G F Tian; X J Liu; G S Cao; H L Newmark; A H Conney; R L Chang
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

2.  Different biological effects of the two protein kinase C activators bryostatin-1 and TPA on human carcinoma cell lines.

Authors:  K G Steube; D Grunicke; H G Drexler
Journal:  Invest New Drugs       Date:  1994       Impact factor: 3.850

Review 3.  Biology of the protein kinase C family.

Authors:  C A O'Brian; N E Ward
Journal:  Cancer Metastasis Rev       Date:  1989-12       Impact factor: 9.264

4.  Release of cell surface proteoglycans from differentiating colon cells proceeds by cleavage of lipophilic anchor peptides.

Authors:  J A McBain; G C Mueller
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

Review 5.  Towards selective pharmacological modulation of protein kinase C--opportunities for the development of novel antineoplastic agents.

Authors:  A Gescher
Journal:  Br J Cancer       Date:  1992-07       Impact factor: 7.640

6.  Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ.

Authors:  M L Saxon; X Zhao; J D Black
Journal:  J Cell Biol       Date:  1994-08       Impact factor: 10.539

7.  Phorbol ester and bryostatin effects on growth and the expression of oestrogen responsive and TGF-beta 1 genes in breast tumour cells.

Authors:  J E Nutt; A L Harris; J Lunec
Journal:  Br J Cancer       Date:  1991-10       Impact factor: 7.640
  7 in total

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