Monica Chowdhry1, Douglas Haden2, Suzanne Kemper1, Kristen Helmick1, Muhammad Kawsara3, Ashley Huggett4, Andrea Stark1, Ahmad Khan1, Muhammad Shah5, Mustafa Bhaty6, Junaid Farooq1, Shailendra Singh1, Brittain McJunkin1. 1. West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA. 2. Department of Critical Care/Pulmonary Disease, Atrium Health's Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA. 3. Department of Internal Medicine, West Virginia University Health Sciences Center, Morgantown, 1 Medical Center Drive, Morgantown, WV 26505, USA. 4. Department of Internal Medicine, Prisma Health/University of South Carolina School of Medicine, 2 Medical Park, Columbia, SC 29203, USA. 5. Addiction Science Center, University of Cincinnati Medical Center, 3132 Harvey Ave., Cincinnati, OH 45239, USA. 6. Department of Internal Medicine, Southside Regional Medical Center, 200 Medical Park Blvd. Petersburg, VA 23805, USA.
Abstract
Aim: We sought to determine if opioid exposure may have a detrimental effect on the course of Clostridioides difficile infection (CDI). Materials & methods: We compared opioid exposure in patients with well-defined severe CDI and non-severe CDI. Results: Following exclusions, 403 records were reviewed. Of this group, 128/403 (31.7%) were determined to have severe CDI by strict criteria, and 275/403 (68.3%) were found to have non-severe CDI. Full multivariate regression and reduced model of potential predictors for severe CDI showed no association with opioids prescribed. Conclusion: Opioid exposure (predominantly in modest range) does not appear to be a risk factor for severe healthcare-associated CDI.
Aim: We sought to determine if opioid exposure may have a detrimental effect on the course of Clostridioides difficile infection (CDI). Materials & methods: We compared opioid exposure in patients with well-defined severe CDI and non-severe CDI. Results: Following exclusions, 403 records were reviewed. Of this group, 128/403 (31.7%) were determined to have severe CDI by strict criteria, and 275/403 (68.3%) were found to have non-severe CDI. Full multivariate regression and reduced model of potential predictors for severe CDI showed no association with opioids prescribed. Conclusion: Opioid exposure (predominantly in modest range) does not appear to be a risk factor for severe healthcare-associated CDI.
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