Sizheng Steven Zhao1, Houchen Lyu2,3, Kazuki Yoshida4. 1. Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK. 2. National Clinical Research Center for Musculoskeletal Diseases, General Hospital of Chinese PLA, Beijing, China. 3. Department of Orthopedics, General Hospital of Chinese PLA, Beijing, China. 4. Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, USA.