Glenn J Jaffe1, Usha Chakravarthy2, K Bailey Freund3, Robyn H Guymer4, Frank G Holz5, Sandra Liakopoulos6, Jordi M Monés7, Philip J Rosenfeld8, Srinivas R Sadda9, David Sarraf10, Steffen Schmitz-Valckenberg11, Richard F Spaide3, Giovanni Staurenghi12, Adnan Tufail13, Christine A Curcio14. 1. Department of Ophthalmology, Duke University, Durham, North Carolina. Electronic address: jaffe001@mc.duke.edu. 2. Center for Public Health, The Queen's University of Belfast, Belfast, United Kingdom. 3. Vitreous Retina Macula Consultants of New York, New York, New York. 4. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Department of Surgery (Ophthalmology), University of Melbourne, Melbourne, Australia. 5. Department of Ophthalmology, University of Bonn, Bonn, Germany. 6. Department of Ophthalmology, Faculty of Medicine and University Hospital, Cologne, Germany. 7. Institut de la Màcula and Barcelona Macula Foundation, Barcelona, Spain. 8. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. 9. Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. 10. Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. 11. John A. Moran Eye Center, University of Utah, Salt Lake City, Utah. 12. Eye Clinic, Department of Biomedical and Clinical Sciences "Luigi Sacco," Luigi Sacco Hospital, University of Milan, Milan, Italy. 13. Moorfields Eye Hospital NHS Trust and Institute of Ophthalmology, University College London, London, United Kingdom. 14. Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Abstract
PURPOSE: To provide an image-based description of retinal features associated with risk for development of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD), as visualized with multimodal imaging anchored by structural OCT. DESIGN: Consensus meeting. PARTICIPANTS: International group that included those with expertise in imaging and AMD basic science and histology, and those with Reading Center experience in AMD clinical trials. METHODS: As part of the Classification of Atrophy Meeting program, an international group of experts analyzed and discussed retinal multimodal imaging features in eyes with AMD associated with GA, risk of progression to GA, or both. Attendees undertook premeeting grading exercises that were reviewed during the meeting sessions. Meeting presentations illustrated established and investigational multimodal imaging features and associated histologic features. Each of these different features were then discussed openly by the entire group to arrive at consensus definitions. These definitions were applied to 40 additional images that were graded independently by attendees to refine the consensus definitions and descriptions further. RESULTS: Consensus was reached on images with descriptors for 12 features. These features included components of outer retinal atrophy (e.g., ellipsoid zone disruption), components of complete retinal pigment epithelium (RPE) and outer retinal atrophy (e.g., RPE perturbation with associated hypotransmission or hypertransmission), features frequently seen in eyes with atrophy (e.g., refractile drusen), and features conferring risk for atrophy development (e.g., hyperreflective foci, drusen, and subretinal drusenoid deposits). CONCLUSIONS: An international consensus on terms and descriptions was reached on multimodal imaging features associated GA and with risk for GA progression in eyes with AMD. We believe this information will be useful to clinicians who manage patients with AMD, researchers who study AMD disease interventions and pathogenesis, and those who design clinical trials for therapies targeting earlier AMD stages than GA expansion.
PURPOSE: To provide an image-based description of retinal features associated with risk for development of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD), as visualized with multimodal imaging anchored by structural OCT. DESIGN: Consensus meeting. PARTICIPANTS: International group that included those with expertise in imaging and AMD basic science and histology, and those with Reading Center experience in AMD clinical trials. METHODS: As part of the Classification of Atrophy Meeting program, an international group of experts analyzed and discussed retinal multimodal imaging features in eyes with AMD associated with GA, risk of progression to GA, or both. Attendees undertook premeeting grading exercises that were reviewed during the meeting sessions. Meeting presentations illustrated established and investigational multimodal imaging features and associated histologic features. Each of these different features were then discussed openly by the entire group to arrive at consensus definitions. These definitions were applied to 40 additional images that were graded independently by attendees to refine the consensus definitions and descriptions further. RESULTS: Consensus was reached on images with descriptors for 12 features. These features included components of outer retinal atrophy (e.g., ellipsoid zone disruption), components of complete retinal pigment epithelium (RPE) and outer retinal atrophy (e.g., RPE perturbation with associated hypotransmission or hypertransmission), features frequently seen in eyes with atrophy (e.g., refractile drusen), and features conferring risk for atrophy development (e.g., hyperreflective foci, drusen, and subretinal drusenoid deposits). CONCLUSIONS: An international consensus on terms and descriptions was reached on multimodal imaging features associated GA and with risk for GA progression in eyes with AMD. We believe this information will be useful to clinicians who manage patients with AMD, researchers who study AMD disease interventions and pathogenesis, and those who design clinical trials for therapies targeting earlier AMD stages than GA expansion.
Authors: Andreas Berlin; Mark E Clark; Thomas A Swain; Nathan A Fischer; Gerald McGwin; Kenneth R Sloan; Cynthia Owsley; Christine A Curcio Journal: Transl Vis Sci Technol Date: 2022-10-03 Impact factor: 3.048
Authors: Rowena Schultz; Somar Hasan; Christine A Curcio; Roland T Smith; Daniel Meller; Martin Hammer Journal: Acta Ophthalmol Date: 2021-07-13 Impact factor: 3.988
Authors: Marius Book; M Ziegler; K Rothaus; H Faatz; M Gutfleisch; G Spital; A Lommatzsch; D Pauleikhoff Journal: Ophthalmologe Date: 2021-08-05 Impact factor: 1.059