Nirav Patil1, Michael E Kelly2, Debra Nana Yeboa3, Robin A Buerki4, Gino Cioffi1,5, Sweta Balaji6, Quinn T Ostrom1,7, Carol Kruchko1, Jill S Barnholtz-Sloan1,5,8. 1. Central Brain Tumor Registry of the United States, Hinsdale, Illinois. 2. Department of Pediatrics, Northeast Ohio Medical University, Rootstown, Ohio. 3. Department of Radiation Oncology at University of Texas, MD Anderson Cancer Center. 4. Department of Neurology, University Hospitals, and Case Comprehensive Cancer Center, Cleveland, Ohio. 5. The Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio. 6. Hawken High School, Gates Mills, Ohio. 7. Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas. 8. Cleveland Center for Health Outcomes Research (CCHOR) Clevleand, Ohio.
Abstract
BACKGROUND: Limited population-based data exist for the brainstem gliomas for children ages ≤19 years, which includes high-grade aggressively growing tumors such as diffuse intrinsic pontine glioma (DIPG). We examined the overall incidence and survival patterns in children with brainstem high-grade glioma (HGG) by age, sex, and race and ethnicity. METHODS: We used data from Central Brain Tumor Registry of the United States (CBTRUS), obtained through data use agreements with the Centers for Disease Control (CDC) and the National Cancer Institute (NCI) from 2000 to 2017, and survival data from the CDCs National Program of Cancer Registries (NPCR), from 2001 to 2016 for malignant brainstem HGG for ages ≤19 years (per WHO ICD-O-3 codes). HGG was determined by established histologic and/or imaging criteria. Age-adjusted incidence rates and survival data were used to assess differences overall and by age, sex race, and ethnicity. RESULTS: The incidence of brainstem HGG was higher among the female and Non-Hispanic population. Majority (69.8%) of these tumors were diagnosed radiographically. Incidence was higher in children aged 1-9 years compared to older children. Whites had a higher incidence compared to Blacks. However, the risk of death was higher among Blacks and Other race compared to Whites. There was no difference in survival by sex. CONCLUSIONS: We report the most comprehensive incidence and survival data on these lethal brainstem HGGs. Incidence and survival among patients with brainstem HGGs differed significantly by race, ethnicity, age-groups, and grade.
BACKGROUND: Limited population-based data exist for the brainstem gliomas for children ages ≤19 years, which includes high-grade aggressively growing tumors such as diffuse intrinsic pontine glioma (DIPG). We examined the overall incidence and survival patterns in children with brainstem high-grade glioma (HGG) by age, sex, and race and ethnicity. METHODS: We used data from Central Brain Tumor Registry of the United States (CBTRUS), obtained through data use agreements with the Centers for Disease Control (CDC) and the National Cancer Institute (NCI) from 2000 to 2017, and survival data from the CDCs National Program of Cancer Registries (NPCR), from 2001 to 2016 for malignant brainstem HGG for ages ≤19 years (per WHO ICD-O-3 codes). HGG was determined by established histologic and/or imaging criteria. Age-adjusted incidence rates and survival data were used to assess differences overall and by age, sex race, and ethnicity. RESULTS: The incidence of brainstem HGG was higher among the female and Non-Hispanic population. Majority (69.8%) of these tumors were diagnosed radiographically. Incidence was higher in children aged 1-9 years compared to older children. Whites had a higher incidence compared to Blacks. However, the risk of death was higher among Blacks and Other race compared to Whites. There was no difference in survival by sex. CONCLUSIONS: We report the most comprehensive incidence and survival data on these lethal brainstem HGGs. Incidence and survival among patients with brainstem HGGs differed significantly by race, ethnicity, age-groups, and grade.
Authors: James L Leach; James Roebker; Austin Schafer; Joshua Baugh; Brooklyn Chaney; Christine Fuller; Maryam Fouladi; Adam Lane; Renee Doughman; Rachid Drissi; Mariko DeWire-Schottmiller; David S Ziegler; Jane E Minturn; Jordan R Hansford; Stacie S Wang; Michelle Monje-Deisseroth; Paul G Fisher; Nicholas G Gottardo; Hetal Dholaria; Roger Packer; Katherine Warren; Sarah E S Leary; Stewart Goldman; Ute Bartels; Cynthia Hawkins; Blaise V Jones Journal: Neuro Oncol Date: 2020-11-26 Impact factor: 12.300
Authors: David N Louis; Arie Perry; Guido Reifenberger; Andreas von Deimling; Dominique Figarella-Branger; Webster K Cavenee; Hiroko Ohgaki; Otmar D Wiestler; Paul Kleihues; David W Ellison Journal: Acta Neuropathol Date: 2016-05-09 Impact factor: 17.088
Authors: Eric J Chow; Susan E Puumala; Beth A Mueller; Susan E Carozza; Erin E Fox; Scott Horel; Kimberly J Johnson; Colleen C McLaughlin; Peggy Reynolds; Julie Von Behren; Logan G Spector Journal: Cancer Date: 2010-06-15 Impact factor: 6.860
Authors: Dong-Anh Khuong-Quang; Pawel Buczkowicz; Patricia Rakopoulos; Xiao-Yang Liu; Adam M Fontebasso; Eric Bouffet; Ute Bartels; Steffen Albrecht; Jeremy Schwartzentruber; Louis Letourneau; Mathieu Bourgey; Guillaume Bourque; Alexandre Montpetit; Genevieve Bourret; Pierre Lepage; Adam Fleming; Peter Lichter; Marcel Kool; Andreas von Deimling; Dominik Sturm; Andrey Korshunov; Damien Faury; David T Jones; Jacek Majewski; Stefan M Pfister; Nada Jabado; Cynthia Hawkins Journal: Acta Neuropathol Date: 2012-06-03 Impact factor: 17.088
Authors: Jason Chiang; Alexander K Diaz; Lydia Makepeace; Xiaoyu Li; Yuanyuan Han; Yimei Li; Paul Klimo; Frederick A Boop; Suzanne J Baker; Amar Gajjar; Thomas E Merchant; David W Ellison; Alberto Broniscer; Zoltan Patay; Christopher L Tinkle Journal: Acta Neuropathol Commun Date: 2020-04-23 Impact factor: 7.578
Authors: Sybren L N Maas; Damian Stichel; Thomas Hielscher; Philipp Sievers; Anna S Berghoff; Daniel Schrimpf; Martin Sill; Philipp Euskirchen; Christina Blume; Areeba Patel; Helin Dogan; David Reuss; Hildegard Dohmen; Marco Stein; Annekathrin Reinhardt; Abigail K Suwala; Annika K Wefers; Peter Baumgarten; Franz Ricklefs; Elisabeth J Rushing; Melanie Bewerunge-Hudler; Ralf Ketter; Jens Schittenhelm; Zane Jaunmuktane; Severina Leu; Fay E A Greenway; Leslie R Bridges; Timothy Jones; Conor Grady; Jonathan Serrano; John Golfinos; Chandra Sen; Christian Mawrin; Christine Jungk; Daniel Hänggi; Manfred Westphal; Katrin Lamszus; Nima Etminan; Gerhard Jungwirth; Christel Herold-Mende; Andreas Unterberg; Patrick N Harter; Hans-Georg Wirsching; Marian C Neidert; Miriam Ratliff; Michael Platten; Matija Snuderl; Kenneth D Aldape; Sebastian Brandner; Jürgen Hench; Stephan Frank; Stefan M Pfister; David T W Jones; Guido Reifenberger; Till Acker; Wolfgang Wick; Michael Weller; Matthias Preusser; Andreas von Deimling; Felix Sahm Journal: J Clin Oncol Date: 2021-10-07 Impact factor: 44.544
Authors: Till Milde; Fausto J Rodriguez; Jill S Barnholtz-Sloan; Nirav Patil; Charles G Eberhart; David H Gutmann Journal: Neuro Oncol Date: 2021-10-01 Impact factor: 13.029