INTRODUCTION: Familial hypercholesterolemia (FH) is a genetic disorder that causes elevated low-density lipoprotein-cholesterol (LDL-C) levels. If undiagnosed and untreated in childhood, affected individuals can suffer premature health complications. Statins reduce the risks of complications for adults, but less is known about children. This systematic review examined the effectiveness of statin therapy for lowering LDL-C levels in children with FH. METHOD: Medline Ovid, Embase, CINAHL, and Allied Health Literature Plus were searched for studies that examined the effectiveness of stains in children ages 1-18 years with heterozygous FH. RESULTS: Of the 706 articles identified, 10 were included in the review. Statin therapy significantly reduced LDL-C levels in pediatric patients with FH. Statins were safe and well-tolerated with minimal adverse effects. DISCUSSION: Pediatric providers should be familiar with diagnosis, treatment, and management of FH to successfully lower LDL-C levels and avoid potential long-term health effects. Evidence suggests statins are safe and effective in children with FH.
INTRODUCTION:Familial hypercholesterolemia (FH) is a genetic disorder that causes elevated low-density lipoprotein-cholesterol (LDL-C) levels. If undiagnosed and untreated in childhood, affected individuals can suffer premature health complications. Statins reduce the risks of complications for adults, but less is known about children. This systematic review examined the effectiveness of statin therapy for lowering LDL-C levels in children with FH. METHOD: Medline Ovid, Embase, CINAHL, and Allied Health Literature Plus were searched for studies that examined the effectiveness of stains in children ages 1-18 years with heterozygous FH. RESULTS: Of the 706 articles identified, 10 were included in the review. Statin therapy significantly reduced LDL-C levels in pediatric patients with FH. Statins were safe and well-tolerated with minimal adverse effects. DISCUSSION: Pediatric providers should be familiar with diagnosis, treatment, and management of FH to successfully lower LDL-C levels and avoid potential long-term health effects. Evidence suggests statins are safe and effective in children with FH.
Authors: Veronika Sanin; Raphael Schmieder; Sara Ates; Lea Dewi Schlieben; Jens Wiehler; Ruoyu Sun; Manuela Decker; Michaela Sander; Stefan Holdenrieder; Florian Kohlmayer; Anna Friedmann; Volker Mall; Therese Feiler; Arne Dreßler; Tim M Strom; Holger Prokisch; Thomas Meitinger; Moritz von Scheidt; Wolfgang Koenig; Georg Leipold; Heribert Schunkert Journal: Eur J Public Health Date: 2022-06-01 Impact factor: 4.424
Authors: Pier Paolo Bassareo; Stephen T O'Brien; Esme Dunne; Sophie Duignan; Eliana Martino; Francesco Martino; Colin J Mcmahon Journal: Children (Basel) Date: 2022-06-30