Bilge Piri Cinar1, Refik Kunt2, Burcu Yuksel3, Halil Gulluoglu4, Idris Sayilir5, Sibel Celiker Uslu5, Eylem Ozaydin Goksu3, Nazlı Gamze Bülbül6, Baykal Yildiz7, Didem Oz8, Ahmet Onur Keskin9, Osman Korucu10, Kursad Akpinar5, Volkan Solmaz11, Meliha Akpinar12, Fatma Zehra Altunc3, Zeynep Elmas4, Bilgehan Acikgoz13. 1. Department of Neurology, Zonguldak Bülent Ecevit University, Zonguldak, Turkey. 2. Department of Neurology, Aydin State Hospital, Aydin, Turkey. 3. Department of Neurology, Antalya Training and Research Hospital, Antalya, Turkey. 4. Department of Neurology, Medical Park İzmir Hospital, Izmir, Turkey. 5. Department of Neurology, Samsun Training and Research Hospital, Samsun, Turkey. 6. Department of Neurology, Mus State Hospital, Mus, Turkey. 7. Department of Neurology, Dr Ersin Arslan Training and Research Hospital, Gaziantep, Turkey. 8. Department of Neurology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. 9. Department of Neurology, Eskisehir Yunus Emre State Hospital, Eskisehir, Turkey. 10. Department of Neurology, Keciören Training and Research Hospital, Ankara, Turkey. 11. Department of Neurology, Istanbul Acibadem Hospital, Istanbul, Turkey. 12. Department of Neurology, Trakya University Faculty of Medicine, Edirne, Turkey. 13. Department of Public Health, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.
Abstract
AIM OF STUDY: The NLR is a simple and inexpensive parameter that is useful as a marker of subclinical inflammation. The purpose of this study was to investigate the clinical characteristics of patients diagnosed with acute cerebral ischemia at the time of initial evaluation in the emergency department. PATIENTS AND METHODS: The study was designed as a multicentre cross-sectional study of acute ischemic stroke patients. Neurological evaluations were assessed using the NIHSS and mRS. Evaluations included the results of patients' laboratory tests performed at the time of presentation to the emergency department. RESULTS: Seven hundred and thirty-five ischemic stroke patients were included in the study. Stroke cases assessed by the mRS as mild or severe showed significant differences with respect to age, leukocyte counts, neutrophil counts, NLR, LDL cholesterol values, and serum glucose values (P = .001). When analysed using NIHSS, lymphocyte levels were significantly higher in very severe stroke cases compared with mild, moderate, and severe cases. NLR was also significantly higher in very severe stroke cases and severe stroke cases as compared with the mild and moderate stroke groups. Neurological evaluations assessed using the mRS showed a mild positive correlation with neutrophil and leukocyte count and a weak correlation with the NLR. CONCLUSION: The NLR exhibited a significant correlation with the results of the mRS and NIHSS. The NLR measured in the very early period was also significantly associated with clinical condition. These results suggest that high NLR values may be a marker of stroke' severity.What's known Stroke is an important disease that has a significant impact on mortality and morbidity and is closely related to the aging world population. In recent years, highly innovative approaches have been developed in the treatment of stroke. Although a long distance has been covered in the early diagnosis of stroke, the ability to predict the severity of the disease with many parameters is still up to date. What's new At the time of admission, in the absence of infection, parameters such as leukocytelymphocyte count and NLR may be telling about stroke severity. Demonstrating the utility of these simple, practical, inexpensive and naninvasive parameters to predict stroke severity can contribute to the scoring to be established at the time of initial diagnosis.
AIM OF STUDY: The NLR is a simple and inexpensive parameter that is useful as a marker of subclinical inflammation. The purpose of this study was to investigate the clinical characteristics of patients diagnosed with acute cerebral ischemia at the time of initial evaluation in the emergency department. PATIENTS AND METHODS: The study was designed as a multicentre cross-sectional study of acute ischemic strokepatients. Neurological evaluations were assessed using the NIHSS and mRS. Evaluations included the results of patients' laboratory tests performed at the time of presentation to the emergency department. RESULTS: Seven hundred and thirty-five ischemic strokepatients were included in the study. Stroke cases assessed by the mRS as mild or severe showed significant differences with respect to age, leukocyte counts, neutrophil counts, NLR, LDL cholesterol values, and serum glucose values (P = .001). When analysed using NIHSS, lymphocyte levels were significantly higher in very severe stroke cases compared with mild, moderate, and severe cases. NLR was also significantly higher in very severe stroke cases and severe stroke cases as compared with the mild and moderate stroke groups. Neurological evaluations assessed using the mRS showed a mild positive correlation with neutrophil and leukocyte count and a weak correlation with the NLR. CONCLUSION: The NLR exhibited a significant correlation with the results of the mRS and NIHSS. The NLR measured in the very early period was also significantly associated with clinical condition. These results suggest that high NLR values may be a marker of stroke' severity.What's known Stroke is an important disease that has a significant impact on mortality and morbidity and is closely related to the aging world population. In recent years, highly innovative approaches have been developed in the treatment of stroke. Although a long distance has been covered in the early diagnosis of stroke, the ability to predict the severity of the disease with many parameters is still up to date. What's new At the time of admission, in the absence of infection, parameters such as leukocytelymphocyte count and NLR may be telling about stroke severity. Demonstrating the utility of these simple, practical, inexpensive and naninvasive parameters to predict stroke severity can contribute to the scoring to be established at the time of initial diagnosis.