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Literature DB >> 33340798

Furin cleavage sites naturally occur in coronaviruses.

Abstract

The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A 12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which raised controversy views on origin of the virus. Here we analyzed the phylogenetic relationships of coronavirus spike proteins and mapped furin recognition motif on the tree. Furin cleavage sites occurred independently for multiple times in the evolution of the coronavirus family, supporting the natural occurring hypothesis of SARS-CoV-2.

Entities: Chemical Disease Gene Species

Year: 2020 PMID： 33340798 DOI： 10.1016/j.scr.2020.102115

Source DB: PubMed Journal: Stem Cell Res ISSN： 1873-5061 Impact factor: 2.020

28 in total

1. The COVID lab-leak hypothesis: what scientists do and don't know.

Authors: Amy Maxmen; Smriti Mallapaty
Journal: Nature Date: 2021-06-08 Impact factor: 49.962

Review 2. The Lancet Commission on lessons for the future from the COVID-19 pandemic.

Authors: Jeffrey D Sachs; Salim S Abdool Karim; Lara Aknin; Joseph Allen; Kirsten Brosbøl; Francesca Colombo; Gabriela Cuevas Barron; María Fernanda Espinosa; Vitor Gaspar; Alejandro Gaviria; Andy Haines; Peter J Hotez; Phoebe Koundouri; Felipe Larraín Bascuñán; Jong-Koo Lee; Muhammad Ali Pate; Gabriela Ramos; K Srinath Reddy; Ismail Serageldin; John Thwaites; Vaira Vike-Freiberga; Chen Wang; Miriam Khamadi Were; Lan Xue; Chandrika Bahadur; Maria Elena Bottazzi; Chris Bullen; George Laryea-Adjei; Yanis Ben Amor; Ozge Karadag; Guillaume Lafortune; Emma Torres; Lauren Barredo; Juliana G E Bartels; Neena Joshi; Margaret Hellard; Uyen Kim Huynh; Shweta Khandelwal; Jeffrey V Lazarus; Susan Michie
Journal: Lancet Date: 2022-09-14 Impact factor: 202.731

3. Molecular Dynamics Studies on the Structural Stability Prediction of SARS-CoV-2 Variants Including Multiple Mutants.

Authors: Kwang-Eun Choi; Jeong-Min Kim; Jee Eun Rhee; Ae Kyung Park; Eun-Jin Kim; Cheon Kwon Yoo; Nam Sook Kang
Journal: Int J Mol Sci Date: 2022-04-29 Impact factor: 6.208

4. Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses.

Authors: Edward R Kastenhuber; Jared L Johnson; Tomer M Yaron; Marisa Mercadante; Lewis C Cantley
Journal: bioRxiv Date: 2022-06-16

5. Should we discount the laboratory origin of COVID-19?

Authors: Rossana Segreto; Yuri Deigin; Kevin McCairn; Alejandro Sousa; Dan Sirotkin; Karl Sirotkin; Jonathan J Couey; Adrian Jones; Daoyu Zhang
Journal: Environ Chem Lett Date: 2021-03-25 Impact factor: 13.615

Review 6. Dynamic, but Not Necessarily Disordered, Human-Virus Interactions Mediated through SLiMs in Viral Proteins.

Authors: Heidy Elkhaligy; Christian A Balbin; Jessica L Gonzalez; Teresa Liberatore; Jessica Siltberg-Liberles
Journal: Viruses Date: 2021-11-26 Impact factor: 5.048

Review 7. Furin cleavage sites in the spike proteins of bat and rodent coronaviruses: Implications for virus evolution and zoonotic transfer from rodent species.

Authors: Alison E Stout; Jean K Millet; Michael J Stanhope; Gary R Whittaker
Journal: One Health Date: 2021-06-22

8. Pleural empyema associated with alveolar-pleural fistulas in severe acute respiratory syndrome coronavirus 2.

Authors: Duilio Divisi; Gino Zaccagna; Chiara Angeletti; Elena Cicerone; Andrea De Vico; Riccardo Moretti; Giovanna Imbriglio; Nadia Carbuglia; Gina Rosaria Quaglione; Sofia Chiatamone Ranieri; Roberto Crisci
Journal: Clin Case Rep Date: 2021-06-22

9. Clinical Trials of COVID-19 Therapies Should Account for Diabetes and Hyperglycemia.

Authors: David C Klonoff; Jordan Messler; Timothy Valk; Ram Jagannathan; Francisco J Pasquel; Guillermo E Umpierrez
Journal: J Diabetes Sci Technol Date: 2021-06-23

10. Two short low complexity regions (LCRs) are hallmark sequences of the Delta SARS-CoV-2 variant spike protein.

Authors: Arturo Becerra; Israel Muñoz-Velasco; Abelardo Aguilar-Cámara; Wolfgang Cottom-Salas; Adrián Cruz-González; Alberto Vázquez-Salazar; Ricardo Hernández-Morales; Rodrigo Jácome; José Alberto Campillo-Balderas; Antonio Lazcano
Journal: Sci Rep Date: 2022-01-18 Impact factor: 4.379