Urolithiasis: Presentation and Surgical Outcome at a Tertiary Care Hospital in Ethiopia.

BACKGROUND: The prevalence of urolithiasis is on a rising trend in tropical and sub-Saharan African countries. The treatment options and data on the surgical outcome are limited in our country. This study was designed to assess the clinical presentation, surgical management and outcome of patients operated on for urolithiasis. PATIENTS AND MATERIALS: A retrospective study of all patients admitted and operated for urolithiasis at St. Paul's hospital millennium medical college (SPHMMC) from July, 2016 to December, 2017 was conducted. Factors associated with surgical outcome were identified with binary logistic regression.
RESULTS: Urolithiasis constituted 247 (30.0%) of 824 urologic admissions. Of these, 202 (Male:Female = 2:1) patients were investigated. The mean age was 37.1 ± 14.4 years (range, 10-85 years). The mean duration of illness was 16.7 ± 18.7 months and the commonest presenting symptom was isolated flank pain (97, 48.0%). A majority of the patients (186, 92.1%) had upper tract stones of which 96 (51.6%) were renal stones. More than two-thirds (164, 81.2%) of the patients had complications at presentation, and hydronephrosis (148, 73.3%) was the major one. Half of the patients (104, 51.5%) were treated with endoscopic procedures, 88 (43.6%) with open stone surgery and in 10 (4.9%) patients both were performed. Nephrectomy was done to 15 (7.4%) patients. Intraoperative and postoperative complications were noted in 16 (7.9%) and 26 (12.9%) patients, respectively. These complications were higher in patients with comorbid illness (AOR = 2.44; 95% CI 1.12-5.31; p = 0.024). Complete stone clearance was achieved in more than half of the clients (114, 61.0%). Multiple stones (AOR = 8.33; 95% CI 2.53-27.43; p < 0.0001) and endoscopic procedures (AOR = 4.17; 95% CI 1.57-10.71; p = 0.003) had significant association with incomplete stone clearance.
CONCLUSION: Patients' presentation in this review was not different from studies elsewhere. Endoscopic procedures are emerging in our set up; however, it was significantly associated with incomplete stone clearance. Strategies to improve outcome (stone clearance) need to be implemented accordingly.

Introduction

Urolithiasis is defined as the formation or occurrence of stone(s) at any level of the urinary tract (kidney, ureter, bladder and urethra).1–5 It is the third most common pathology affecting the urinary tract and it has been described since antiquity.6–10

The incidence and prevalence of a urinary stone vary with geographic location, race, age, occupation, and sex. Worldwide the prevalence is estimated to be 1–5% and higher in developed nations (2–13%) than developing ones (0.5–1%).6,7,11,12 Even if it is more prevalent in countries located in the “Afro-Asian stone forming belt“, it is on a rising trend in tropical and sub-Saharan African countries due to global climate change and growing socio-economic status as manifested by westernized diet and lifestyle.1,4,5,7,12–15 This has also shifted the site of stone formation from lower tract to the upper tract and the disease once limited to men is increasingly gender blind.6–8

The incidence of urolithiasis peaks in the 4th to 6th decade of life and the presentation may range from no or mild symptom to life-threatening sepsis and obstructive renal failure.6,7,9

The treatment options include watchful waiting, stone dissolution, medical expulsive therapy, extracorporeal treatment, uroendoscopic interventions and open stone surgery.12,16 Overall, the specific treatment relies on stone composition, site, size, number, patients’ general condition and preference, and institutional capacity.17–19

Despite the advancement of minimally invasive and noninvasive management of stone disease, which has become the gold standard treatment, open stone surgery remains the technique of choice in most developing countries.2,3,16,20,21 This reflects the lack of trained professionals and endourologic instruments.16,22–24

As Ethiopia is a fast-growing, sub-Saharan Africa country, located near to the Afro-Asian stone belt, the burden is expected to be rising and becoming a public health issue.5 However, data are scarce and the treatment options are limited. Hence this study assesses the clinical presentation, surgical management and outcome of patients operated on for urolithiasis.

Patients and Materials

A retrospective cross-sectional study was conducted to assess the clinical presentation, surgical management and outcome of all patients who were admitted and operated on for urolithiasis between July 1st 2016 and December 31st 2017 at St. Paul’s hospital millennium medical college (SPHMMC). SPHMMC is a tertiary care teaching hospital found in Addis Ababa, Ethiopia which serves as a referral center for patients from all over the country. The urology unit is under the department of surgery with a capacity of 21 beds and each year more than 500 major urologic procedures are performed.

Ward and operation theater registries were used to identify all urologic admissions as well as subjects who were admitted and operated on for urolithiasis during the study period. A total of 247 cases of urolithiasis were operated on in 18 months and of these 202 (81.8%) medical records were retrieved and investigated for reasons such as missed medical records and incomplete data. A pretested data collection format was employed to collect information regarding patient’s socio-demographic characteristics, clinical presentation, preoperative workup, type of surgical management, intraoperative findings and surgical outcome (complication, mortality and stone clearance).

Data were checked for completeness, accuracy, consistency then coded and entered into SPSS version 23 for analysis. Binary logistic regression was used to identify factors associated with surgical outcome (stone clearance and operative complications). Variables with a p-value < 0.3 during a bivariate analysis were further subjected to a multivariate analysis and considered significant at p-values < 0.05. Fifteen patients with unknown stone clearance status were excluded during the analysis of factors associated with incomplete clearance. Results were presented using texts, tables and central tendency statistics.

This study was conducted in accordance with the Declaration of Helsinki and was approved by SPHMMC institutional review board (IRB). Since patients were not contacted and data were extracted retrospectively from patients’ chart, the IRB waived the study without patients’ consent. All the data were anonymized and confidentiality was kept throughout the study.

Results

Among 824 urologic admissions, 247 (30.0%) were for urolithiasis. Of these,202 (81.8%) cases were studied. Males constituted 135 (66.8%) admissions with a male to female ratio of 2:1. The mean age was 37.1±14.4 years (range, 10−85 years) and nearly one third (61, 30.2%) of patients were aged between 20 and 29 years. The prevalence of urolithiasis was only higher in females (61.5% vs 38.5%) in the second decade of life, otherwise, males predominate. In general, urolithiasis was more prevalent (147, 72.8%) in the age group 20–49 years. One third (68, 33.7%) of patients were civil servants and most (83, 41.1%) came from Addis Ababa (Table 1).

Table 1

Sociodemographic Characteristics of Patients Admitted and Operated On for Urolithiasis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia, from July 2016 to December 2017

Variables	Sex		Total n (%)
	Male n (%)	Female n (%)
Age
10–19	5(38.5)	8(61.5)	13(6.4)
20–29	42(68.9)	19(31.1)	61(30.2)
30–39	27(62.8)	16(37.2)	43(21.3)
40–49	31(72.1)	12(27.9)	43(21.3)
50–59	15(60.0)	10(40.0)	25(12.4)
60–69	11(84.6)	2(15.4)	13(6.4)
≥70	4(100)	0(0)	4(2.0)
Region/Address
Addis Ababa	55(66.3)	28(33.7)	83(41.1)
Oromia	42(68.9)	19(31.1)	61(30.2)
SNNP	24(75.0)	8(25.0)	32(15.8)
Amhara	13(54.2)	11(45.8)	24(11.9)
Tigray	1(50.0)	1(50.0)	2(1.0)
Occupation
Civil servant	50(72.5)	19(27.5)	69(34.1)
Trader	25(83.3)	5(16.7)	30(14.8)
Unknown	16(64.0)	9(36.0)	25(12.4)
Student	13(59.1)	9(40.9)	22(10.9)
Farmer	19(90.5)	2(9.5)	21(10.4)
Factory workers	13(72.2)	5(27.8)	18(8.9)
Housewife	—	17(100)	17(8.4)

The mean duration of illness was 16.7±18.7 months (range, 1–120 months). Flank pain alone (97, 48.0%) and flank pain with hematuria (55, 27.2%) were the two leading presenting symptoms. Comorbidities were identified in 56 (27.7%) patients and hypertension (43, 21.2%) was the commonest (Table 2).

Table 2

Presenting Symptoms and Associated Comorbidities in Patients Operated On for Urolithiasis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia, from July 2016 to December 2017

Variables	Total n (%)
Presenting symptoms
Flank pain	97(48.0)
Flank pain and Hematuria	55(27.2)
Flank pain, Hematuria and Dysuria	32(15.8)
Hematuria	7(3.5)
Dysuria	6(3.0)
Acute urinary retention	3(1.4)
Hematuria and Dysuria	2(1.0)
Comorbidities
No comorbidity	146(72.3)
Hypertension	27(13.4)
Hypertension and Diabetes Mellitus	14(6.9)
Diabetes Mellitus	7(3.5)
HIV Infection*	6(3.0)
Hypertension and HIV Infection	2(1.0))

Abbreviation: *HIV, human immunodeficiency virus.

Ultrasound was the main diagnostic imaging obtained in all patients followed by intravenous pyelogram (IVP) (153, 75.7%), Computed tomography (CT) scan (40, 19.8%) and X-ray of the kidney-ureters-bladder (KUB) (23, 11.4%).

Majority of the stones were upper tract (186, 92.1%) out of which 96 (47.5%) were renal stones, 62 (30.7%) were ureteric stones and 28 (13.9%) were concomitant renal and ureteric stones. Regarding the anatomic location, the left kidney (43, 21.3%) was the commonest site followed by right kidney (39, 19.3%) and left ureter (33, 16.3%). Overall, urolithiasis occurred more on the left side (102, 50.5%) than the right (87, 43.1) (Table 3).

Table 3

Anatomic Locations of Stones in Patients Admitted and Operated On for Urolithiasis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia, from July 2016 to December 2017

Anatomic Location	Total n (%)
Kidney
Left	43(21.3)
Right	39(19.3)
Both	14(6.9)
Ureter
Left	33(16.3)
Right	28(13.9)
Both	1(0.5)
Kidney and Ureter
Both Kidneys and Left Ureter	9 (4.5)
Both Kidneys and Right Ureter	1(0.5)
Right Kidney and Right Ureter	6(3.0)
Right Kidney and Left Ureter	2(1.0)
Left Kidney and Right Ureter	5(2.5)
Left Kidney and Left Ureter	5(2.5)
Urinary bladder	16(7.9)

Among the ureteric stones, 28 (45.2%) found in the proximal ureter, 27 (43.5%) in the mid-ureter and 7 (11.3%) in the distal ureter.

Of the patients, 95 (47.0%) had a single stone, 67 (33.2%) had multiple stones and 40 (19.8%) had a staghorn stone.

Complications at presentation were seen in more than two-thirds (164, 81.2%) of the patients. Hydronephrosis (148, 73.3%) was the major one followed by renal failure (10, 4.9%) and pyonephrosis (6, 3.0%).

Of the patients, most (104, 51.5%) were treated with endoscopic procedures, 88 (43.6%) with open stone surgery and in 10 (4.9%) patients both open and endoscopic interventions were performed. The most frequently carried out procedures include pyelolithotomy (34, 35.4%) for renal stone, ureterorenoscopy (URS) (56, 90.3%) for ureteric stone, URS (21, 75.0%) for concomitant stones (renal and ureteric) and cystolithotomy (12, 75.0%) for urinary bladder stone. Nephrectomy was done to 15 (7.4%) cases with an indication of pyonephrosis (significant parenchymal destruction) in 3 (1.4%) patients and non-functioning kidney (confirmed IVP) in 12 (6.0%) patients. Overall, URS (103, 51.0%) and pyelolithotomy (40, 19.8%) were the commonest endoscopic and open procedures done to our patients, respectively. Table 4

Table 4

Types of Procedure Performed in Patients with Urolithiasis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia, from July 2016 to December 2017

Diagnosis	Procedure		Total n (%)
Renal Stone	Open	Pyelolithotomy	34(16.8)
		Nephrolithotomy	21(10.4)
		Nephrectomy	14(6.9)
	Endoscopy	Ureterorenoscopy	17(8.4)
		Percutaneous Nephrolithotomy	5(2.5)
	Combined	Pyelolithotomy and Ureterorenoscopy	4(2.0)
		Nephrolithotomy and Ureterorenoscopy	1(0.5)
Ureteric Stone	Open	Ureterolithotomy	3(1.5)
		Nephrectomy	1(0.5)
	Endoscopy	Ureterorenoscopy	56(27.7)
		Laparoscopic Ureterolithotomy	1(0.5)
	Combined	Ureterolithotomy and Ureterorenoscopy	1(0.5)
Renal and Ureteric Stone	Open	Nephrolithotomy	2(1.0)
		Pyelolithotomy	1(0.5)
	Endoscopy	Ureterorenoscopy	21(10.4)
	Combined	Nephrolithotomy and Ureterorenoscopy	2(1.0)
		Pyelolithotomy and Ureterorenoscopy	1(0.5)
		Nephrolithotomy and Laparoscopic Ureterolithotomy	1(0.5)
Urinary Bladder Stone	Open	Cystolithotomy	12 (5.9)
	Endoscopy	Cystolitholapaxy	4(2.0)

Of 40 (19.8%) patients with staghorn stone, 34 (85%) removed with an open procedure, 5 (12.5%) endoscopically and 1 (2.5%) with combined intervention.

Intraoperative and postoperative complications were noted in 16 (7.9%) and 26 (12.9%) patients, respectively. Of these, 5 (2.5%) patients developed both intra- and postoperative complications. Stone migration (9, 4.5%) and surgical site infection (10, 5%) were the commonest complications seen during intraoperative and postoperative periods, respectively (Table 5). Ureter was stented in all patients with stone migration and referred for extra-corporeal shock wave lithotripsy.

Table 5

Intra- and Postoperative Complications in Patients with Urolithiasis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia, from July 2016 to December 2017

Intraoperative Complication	Total n (%)	Postoperative Complication	Total n (%)
No complication	186(92.1)	No complication	176(87.1)
Stone migration	9(4.5)	Surgical site infection	10(5.0)
Bleeding	4(2.0)	Prolonged urine leak	8(4.0)
Adjacent organ injury*	2(1.0)	Renal failure	3(1.5)
Ureteric perforation	1(0.5)	Urosepsis	2(1.0)
		Pneumonia	2(1.0)
		Deep vein thrombosis	1(0.5)

Note: *1(0.5%), Descending colon; 1(0.5%), duodenal injury.

Of the patients, stone removal was complete in 114 (56.4%), partially complete in 68 (33.7%), no clearance in 5 (2.5%) and it is unknown in 15 (7.4%) patients. By excluding patients with unknown stone clearance status, complete stone clearance was possible in 114 (114/187, 61.0%) patients.

Death occurred in 3 (1.5%) patients. Renal failure was the cause of death in two patients and the other patient died from multiorgan failure due to sepsis. Mortality was comparable between patients who underwent endoscopic (1/104, 1.0%) and open procedure (1/88, 1.1%). However, it is much higher when both performed together (1/10, 10.0%).

Stone chemical analysis is not done in all patients due to the lack of laboratory setup.

Factors Associated with Stone Clearance

On bivariate analysis, concomitant use of endoscopy and open procedures, endoscopic procedure and multiple stones were significantly associated with incomplete stone clearance. However, endoscopic procedures (AOR = 4.17; 95% CI 1.57–10.71; p = 0.003) and stone burden (multiple stones) (AOR = 8.33; 95% CI 2.53–27.43; p < 0.0001) remained significantly associated in multivariate analysis (Table 6).

Table 6

Factors Associated with Stone Removal and Operative Complications in Patients with Urolithiasis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia, from July 2016 to December 2017

Variables	Stone Clearance		Crude OddsRatio (95% CI)	AdjustedOdds Ratio (95% CI)
	Incomplete	Complete
Duration of Illness
≤1 year	62	94	1
>1year	11	20	0.83(0.37–1.86)
Location
Kidney	31	58	0.27(0.63–1.14)
Ureter	26	33	0.39(0.90–1.73)
Kidney and Ureter	10	20	0.25(0.51–1.21)
Bladder	6	3	1
Comorbid illness
No	53	81	1
Yes	20	33	0.93(0.48–1.78)
Stone Burden
Single	30	61	1	1
Multiple	36	21	3.49(1.74–6.97) **	8.33(2.53–27.43) **
Staghorn	7	32	0.44(0.18–1.12)	1.60(0.39–6.52)
Type of Procedure
Open Surgery	17	62	1	1
Endoscopic	51	48	3.87(1.99–7.54) **	4.17(1.57–10.71) **
Both	5	4	4.56(1.10–18.86) *	2.65(0.53–13.23)
	Operative Complications
	Yes	No
Age
≤50	28	139	1.72(0.73–4.06)
>50	9	26	1
Sex
Male	24	111	1
Female	13	54	1.11(0.53–2.35)
Stone burden
Single	13	82	1
Multiple	16	51	1.98(0.88–4.45)
Staghorn	8	32	1.58(0.60–4.16)
Comorbid illness
No	20	126	1	1
Yes	17	39	2.75(1.31–5.75) *	2.44(1.12–5.31) *
Location
Kidney	21	75	1.21(0.32–4.66)
Ureter	8	54	0.64(0.15–2.76)
Kidney & Ureter	5	23	0.94(0.10–4.59)
Bladder	3	13	1
Procedure
Endoscopy	14	90	1
Open surgery	19	69	1.77(0.83–3.78)
Both	4	6	4.29(1.07–17.12) *

Notes: *Significantly associated at p-value < 0.05. **Significantly associated at p-value > 0.005.

Factors Associated with Operative Complications

The multivariate analysis identified the presence of comorbid illnesses (AOR = 2.44; 95% CI 1.12–5.31; p = 0.024) was significantly associated with operative complications. However, on bivariate analysis the type of procedure (concomitant use of endoscopic and open procedure) was significantly associated with operative complications (Table 6).

Discussion

In line with the global trend, studies reported an increasing prevalence of urolithiasis in the tropical and sub-Saharan African countries.1,4,5,7,12–14 Similarly, a recent Ethiopian study demonstrated a rising trend over the past 13 years (from 2004 to 2017) and becoming a public health issue.5 Studies done locally showed that urolithiasis represent 13.6% to 33.6% of urologic surgical burden which is consistent with our finding, 30.0%.11,25–27 Furthermore, reports from other countries recognized urolithiasis among the major reasons of urologic surgical admission.2,3,14

Worldwide, the estimated male to female ratio of urolithiasis ranges from 1.5 to 2.5:1.7 Comparable with this, our study and others also confirmed urolithiasis as a male predominant disease.2,4,5,9,10,12,13,15,25,26,28–30 Males are assumed to be susceptible to stone formation for reasons such as lithogenic effect of testosterone, uro-genital anatomy which is prone to stasis and engagement in strenuous work which results in dehydration unless adequately replaced.14,19,24,31 The limited opportunity of women to go to a health facility in our setup was also mentioned as a factor for the male predominance in urolithiasis.5 On the other hand, recent evidences showed a narrowing of gender gap related to changes in diet and increment in rates of diabetes and obesity.6,7,12 More than two third of our patients were between the 3rd and 5th decade of life and the occurrence of stones decreases with age. This holds true in reports from our country and elsewhere.2,5,9,11,13,16,25,29 In contrast to this, studies from USA, Japan and Nigeria found out that calculi are frequent in the 5th and 6th decade of life.1,12,32 This variation may be explained by a difference in study subjects and geographic location. As stone formation is related with comorbid illness, death at an early age might also attribute to this discrepancy.1 Moreover, the higher life expectancy and advanced care in developed nations might contribute to the difference.

Our review and a report by Hounnasso et al witnessed a delayed presentation of patients, 16 months and 5 months, respectively.2 This may reflect the lack of access to essential surgical care and less public awareness to urologic disease in the sub-Saharan African countries.22 Authors reported flank pain, hematuria and dysuria as the main presenting symptoms of urolithiasis, which is also the case in our study.2–4,12,14,25,30 Apart from this, a study conducted by Odzebe et al and Rimtebaye et al found a high rate of acute urinary retention in their review (26.5% and 28.7%).3,21 This variation can be explained by the high incidence of lower tract stone and obstructive conditions in their patients. Literature reported an increased risk of urinary stone disease in individuals with associated conditions such as diabetes and hypertension.7,33 Either or both of these conditions were seen in 24.7% patients in our study, 10.8% in Benin and 17% in Nigeria.2,13 It is well demonstrated that insulin resistance results in low urine pH through impaired kidney ammoniagenesis which in turn leads to stone formation. However, data on the link between hypertension and urinary stone is inconsistent.7,33 On the other hand, a dietary approach to stop hypertension (DASH) was found to decrease the risk of kidney stone formation.34 In this study, 4% of the subjects reported HIV-infection which may increase the risk of stone formation related to the underlying metabolic abnormality and adverse effect of indinavir treatment.35

The choice of diagnostic imaging for urolithiasis is non-contrast-enhanced CT-scan (NCCT) which has a sensitivity and specificity of 93.1% and 96.6%, respectively.36,37 However, its use in sub-Saharan African countries is limited due to its availability.16 In agreement with this, our study and others reported ultrasound and IVP as the main diagnostic imaging performed.2,3,14 Even if ultrasound has low sensitivity to identify urinary stones, it is the initial choice of imaging for reasons such as accessibility, affordability and safety.3,12,16,36 In our study NCCT was utilized in 19.8% of the patients which is very low as compared with a study from Kenya (81%) and Nigeria (57.9%).4,12 The high burden of patients from other disciplines and frequent malfunction maybe the reason for the low use of NCCT in our patient’s diagnosis.

If left untreated, stones may lead to damage by causing obstruction and persistent infection. A review of literature done in Africa by Cassell et al showed hydronephrosis and infection are among the commonly reported clinical presentation of urolithiasis.16 This is consistent with the higher rate of hydronephrosis seen in our patients (73.3%) and other studies done locally by Adualem et al (63%) and Teferi et al (78.2%).11,25 The possible reason for this could be the late presentation of patients preventing early diagnosis and prompt treatment. Even if renal failure at presentation is lower in our review (4.9%) than the reports of Hounnasso et al (8.8%), Adualem et al (15%) and Teferi et al (43.6%), it demands further evaluation with a better study design.2,11,25

Literature reported the migration of stone location from the lower tract to the upper due to changing global climate and socioeconomic status.6–8,33 Our study and other similar studies from Ethiopia and elsewhere found the upper tract as the frequent anatomic site of urolithiasis.2,4,5,10,11,15,25,28,30,38 In contrast to this, Nigerian authors identified the urinary bladder as the commonest location which was attributed by its endemicity and higher rate of poorly treated bladder out late obstruction in their study.12–14,17 Alemu also demonstrated the common occurrence of urinary bladder stones in Mekelle, northern Ethiopia.26 This could be partly due to the difference in the setup in which lower tract stones tend to be managed in a low resource setting and complex stones being referred to higher health facilities. The recent study identified a higher number of staghorn stones than studies done in Ethiopia (10%), Senegal (5.6%) and Iran (2.5%).9,11,20 This might indicate the higher rate of underlying infectious causes in our patients. In contrary to other African studies, our review and a recent Ethiopian study reported that the left kidney was more commonly affected than the right one.5,16,28

Unlike the well revolutionized surgical treatment of urolithiasis in the western world, open stone surgery still remains the mainstay of approach in most developing nations.2,3,14,16,20,24,30 The recently available minimal invasive treatment options include extracorporeal shock wave lithotripsy (ESWL), URS, percutaneous nephrolithotomy (PCNL) and laparoscopic approaches16,30,39 The rate of open surgery in the developed countries ranged from 0.47–5% and it is reserved for indications such as complex stone disease, concomitant anatomical abnormalities, failure of minimal invasive treatments, concurrent open surgery, severe limb contractures, and patient choice.15,39 Authors from Africa reported the rate of endourologic procedures ranged from 30.5–52.8% which is encouraging and in line with our review (51.5%).11,14,16,25 Lack of endoscopic equipment’s, sustainable supply, maintenance, training in urology and delayed patient presentation were the main factors mentioned for the high rate of open surgery in developing nations.22,23,25,38 The reported rate of nephrectomy for stone disease, in Africa urologic centers, ranged from 1.9–17.9%.16 Even if the findings of our study (7.4%) and other studies done in Ethiopia by Adualem et al (8%) and Teferi et al (11.5%) were within this range, it necessitates urgent attention.11,25 A study from Pakistan identified a low rate of nephrectomy (2.33%) due to the low incidence of pyonephrosis and a better treatment plane.30

The overall rate of operative complications in this review was 18.3% and it was less frequent in endoscopic procedures (15.5%) than open stone surgeries (27.5%). Moreover, the presence of comorbid illness was associated with increased odds (p = 0.024) of these complications than their respective groups. In contrast to this, similar studies in Ethiopia reported a higher rate, ranging from 24–30%.11,25,38 This discrepancy might be explained by the higher rate of open stone surgery in their study. However, the complications associated with open stone surgeries were higher in our cohort than studies elsewhere, ranging from 1.7–22.5%.2,3,13,14,21,39 The higher number of comorbid illnesses in our study may account for the difference. Stone migration and SSI were the most frequent operative complications seen in our patients and others.2,3,11,13,14,25,38 Cassell et al reported the rate of surgical site infection in open stone surgeries from 0.8% to 15% which is parallel with our findings.16 This study (1.0%), the ureteroscopy global study (0.7–1.6%) and a similar study done in Ethiopia (1.2%) found similar rates of ureteric perforation following URS.19,40

In our analysis, the overall complete stone clearance was 61.0%, 78.5% in open stone surgery and 48.5% in endoscopic procedures, which is lower than the report by Adualem et al (77.4%) done in our country.11 This could be due to the higher rate of endoscopic interventions in our study, hence multiple stones (p < 0.0001) and endoscopic procedures (p = 0.003) were significantly associated with incomplete stone clearance. In contrast to this, endoscopic interventions in other reports achieved >85% complete stone clearance.19,28 Even if this variation needs further exploration, the potential contributing factors include delayed patient presentation, constraints of appropriate instrument and expertise.

The retrospective nature of the study was the major limitation, resulting in missed data of major parameters such as stone size, risk factors and follow up of patients. The other drawback was the absence of data regarding stone chemical analysis due to the lack of laboratory setup. Otherwise, this study provided pertinent findings regarding presentation, surgical management and outcome of urolithiasis which helps to improve the urologic care in our patients.

In conclusion, the clinical presentation of urolithiasis in our study was not different from studies elsewhere. However, we observed a delayed duration of presentation. Endoscopic interventions are emerging in our set up provided that it is significantly associated with incomplete stone clearance. Operative complications were higher in open stone surgery than endoscopic interventions and significantly associated with the presence of comorbid conditions. Adequate perioperative optimization of patients with comorbid illnesses, implementing effective strategies to improve endourologic platform and increasing public awareness regarding urinary stone disease, were the major issues which should be addressed in our unit. Moreover, a set-up to analyze stone composition needs to be established for preventive care.