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Literature DB >> 3333512

A double-blind clinical trial of prophylactic cloxacillin in open fractures.

Abstract

In 100 patients with first-, second-, and third-degree open fractures, a randomized, double-blind study was carried out to compare prophylactic cloxacillin and placebo. Prophylaxis was started preoperatively and continued for 10 days. The standard fracture treatment consisted of operative stabilization, mostly by means of plates or external fixators. In the cloxacillin group two infections were observed as compared to 12 in the control group. This difference was significant.

Entities: Chemical Disease Species

Mesh：

Substances：
Placebos
Cloxacillin

Year: 1987 PMID： 3333512 DOI： 10.1097/00005131-198701010-00002

Source DB: PubMed Journal: J Orthop Trauma ISSN： 0890-5339 Impact factor: 2.512

Keyword Cloud
Cited

13 in total

1. Multiple systems organ failure.

Authors: J R Border
Journal: Ann Surg Date: 1992-08 Impact factor: 12.969

Review 2. Current Concepts and Ongoing Research in the Prevention and Treatment of Open Fracture Infections.

Authors: Geoffrey D Hannigan; Nicholas Pulos; Elizabeth A Grice; Samir Mehta
Journal: Adv Wound Care (New Rochelle) Date: 2015-01-01 Impact factor: 4.730

3. Compliance and Related Outcomes of Prophylactic Antibiotics in Traumatic Open Fractures.

Authors: Hannah C Johnson; Abby M Bailey; Regan A Baum; Stephanie B Justice; Kyle A Weant
Journal: Hosp Pharm Date: 2019-03-13

Review 4. Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures.

Authors: William J Gillespie; Geert Him Walenkamp
Journal: Cochrane Database Syst Rev Date: 2010-03-17

Review 5. Risk factors for infectious complications after open fractures; a systematic review and meta-analysis.

Authors: Kirsten Kortram; Hans Bezstarosti; Willem-Jan Metsemakers; Michael J Raschke; Esther M M Van Lieshout; Michael H J Verhofstad
Journal: Int Orthop Date: 2017-07-25 Impact factor: 3.075

Review 6. Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs.

Authors: James K-K Chan; Alexander L Aquilina; Sharon R Lewis; Jeremy N Rodrigues; Xavier L Griffin; Jagdeep Nanchahal
Journal: Cochrane Database Syst Rev Date: 2022-04-01

A double-blind clinical trial of prophylactic cloxacillin in open fractures.

1. Multiple systems organ failure.

Review 2. Current Concepts and Ongoing Research in the Prevention and Treatment of Open Fracture Infections.

3. Compliance and Related Outcomes of Prophylactic Antibiotics in Traumatic Open Fractures.

Review 4. Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures.

Review 5. Risk factors for infectious complications after open fractures; a systematic review and meta-analysis.

Review 6. Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs.

7. [Antibiotic prophylaxis in open fractures].

Review 8. Antibiotics for preventing infection in open limb fractures.

Review 9. Antimicrobial agents in orthopaedic surgery: Prophylaxis and treatment.

10. Current concepts of prophylactic antibiotics in trauma: a review.