Ravi Kant1, Vipin Verma2, Siddharth Patel3, Rashmi Chandra4, Rahul Chaudhary5, Alan R Shuldiner6, Kashif M Munir6. 1. Division of Endocrinology, Diabetes and Nutrition, Medical University of South Carolina/AnMed Campus, Anderson, SC 29621, USA. Electronic address: Kant.ravi.md@gmail.com. 2. Department of Medicine, Medical University of South Carolina/AnMed Campus, Anderson, SC 29621, USA. Electronic address: vipinverma87@hotmail.com. 3. Department of Medicine, Decatur Morgan Hospital Decatur Campus, Decatur, AL, USA. 4. Department of Medicine, Medical University of South Carolina/AnMed Campus, Anderson, SC 29621, USA. 5. Department of Medicine, Mayo Clinic, Rochester, MN, USA. 6. Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Abstract
AIM: To compare zinc (Zn) and copper (Cu) levels in US adults with normoglycemia, prediabetes and diabetes, and study the association of serum Zn and Cu levels with pancreatic β cell insulin secretion, pancreatic dysfunction and insulin resistance in US adults with normoglycemia and prediabetes. METHOD: Homeostatic Model Assessment (HOMA2) calculator was used to compute estimates of steady state β cell insulin secretion (HOMA2-B), peripheral insulin sensitivity (HOMA2-S), insulin resistance (HOMA-IR), and disposition index (HOMA-DI) in 804 adult individuals from the National Health and Nutrition Examination Survey (NHANES 2011-2012). RESULTS: There was no significant difference between serum Zn and Cu levels among subjects with normoglycemia, prediabetes, and diabetes. After adjusting for multiple possible confounders, higher serum Zn concentrations were associated with lower β cell insulin secretion (HOMA2-B; p = 0.01) and lower insulin resistance (HOMA-IR; p = 0.04) in the prediabetic subjects. In normoglycemic group, higher serum Zn levels were associated with improved pancreatic function (HOMA-DI; P = 0.02). On the other hand, higher serum Cu levels were associated with increased β cell insulin secretion (HOMA2-B, P = 0.03) only in the subjects with prediabetes. CONCLUSION: These findings support the need for further studies to investigate the role of trace elements in diabetes pathogenesis.
AIM: To compare zinc (Zn) and copper (Cu) levels in US adults with normoglycemia, prediabetes and diabetes, and study the association of serum Zn and Cu levels with pancreatic β cell insulin secretion, pancreatic dysfunction and insulin resistance in US adults with normoglycemia and prediabetes. METHOD: Homeostatic Model Assessment (HOMA2) calculator was used to compute estimates of steady state β cell insulin secretion (HOMA2-B), peripheral insulin sensitivity (HOMA2-S), insulin resistance (HOMA-IR), and disposition index (HOMA-DI) in 804 adult individuals from the National Health and Nutrition Examination Survey (NHANES 2011-2012). RESULTS: There was no significant difference between serum Zn and Cu levels among subjects with normoglycemia, prediabetes, and diabetes. After adjusting for multiple possible confounders, higher serum Zn concentrations were associated with lower β cell insulin secretion (HOMA2-B; p = 0.01) and lower insulin resistance (HOMA-IR; p = 0.04) in the prediabetic subjects. In normoglycemic group, higher serum Zn levels were associated with improved pancreatic function (HOMA-DI; P = 0.02). On the other hand, higher serum Cu levels were associated with increased β cell insulin secretion (HOMA2-B, P = 0.03) only in the subjects with prediabetes. CONCLUSION: These findings support the need for further studies to investigate the role of trace elements in diabetes pathogenesis.