Neil B Newman1, Chirayu G Patel2, George X Ding3, John A Zic4, Jeffrey Zwerner4, Evan C Osmundson3, Austin N Kirschner3. 1. Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: neil.b.newman@vumc.org. 2. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. 3. Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee. 4. Department of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee.
Abstract
INTRODUCTION: Low-dose total skin electron beam therapy provides a durable treatment response for skin lesions caused by cutaneous T-cell lymphoma. We prospectively assessed the durability of response and quality of life for patients receiving low-dose total skin electron beam therapy using a novel rotational technique and dosing regimen. METHODS: Patients completed baseline Skindex-29 quality-of-life surveys and had baseline Modified Severity-Weighted Assessment Tool score recorded. Patients received 12 Gy in 12 fractions with a dual-field rotational technique. The primary outcome was overall response rate, with the secondary outcomes being time to treatment response, duration of clinical benefit, and quality-of-life change. RESULTS: We enrolled 20 patients and recorded an overall response rate of 90%. The median time to treatment response was 6.5 weeks. The baseline Modified Severity-Weighted Assessment Tool score was 55.6 and it declined to a median of 2.2 at last follow-up (P < .001). The median duration of clinical benefit was 21 months. There was a decline in the Skindex-29 total score and every subdomain when each follow-up visit was compared (P = .004). CONCLUSIONS: This prospective study demonstrated a very high overall response rate and improvement in skin-related quality of life. Low-dose rotational total skin electron beam therapy can be implemented routinely in clinical practice.
INTRODUCTION: Low-dose total skin electron beam therapy provides a durable treatment response for skin lesions caused by cutaneous T-cell lymphoma. We prospectively assessed the durability of response and quality of life for patients receiving low-dose total skin electron beam therapy using a novel rotational technique and dosing regimen. METHODS: Patients completed baseline Skindex-29 quality-of-life surveys and had baseline Modified Severity-Weighted Assessment Tool score recorded. Patients received 12 Gy in 12 fractions with a dual-field rotational technique. The primary outcome was overall response rate, with the secondary outcomes being time to treatment response, duration of clinical benefit, and quality-of-life change. RESULTS: We enrolled 20 patients and recorded an overall response rate of 90%. The median time to treatment response was 6.5 weeks. The baseline Modified Severity-Weighted Assessment Tool score was 55.6 and it declined to a median of 2.2 at last follow-up (P < .001). The median duration of clinical benefit was 21 months. There was a decline in the Skindex-29 total score and every subdomain when each follow-up visit was compared (P = .004). CONCLUSIONS: This prospective study demonstrated a very high overall response rate and improvement in skin-related quality of life. Low-dose rotational total skin electron beam therapy can be implemented routinely in clinical practice.
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Authors: K Molloy; C Jonak; F J S H Woei-A-Jin; E Guenova; A M Busschots; A Bervoets; E Hauben; R Knobler; S Porkert; C Fassnacht; R Cowan; E Papadavid; M Beylot-Barry; E Berti; S Alberti Violetti; T Estrach; R Matin; O Akilov; L Vakeva; M Prince; A Bates; M Bayne; R Wachsmuch; U Wehkamp; M Marschalko; O Servitje; D Turner; S Weatherhead; M Wobser; J A Sanches; P McKay; D Klemke; C Peng; A Howles; J Yoo; F Evison; J Scarisbrick Journal: Br J Dermatol Date: 2019-07-28 Impact factor: 9.302
Authors: Thatcher R Heumann; Natia Esiashvili; Sareeta Parker; Jeffrey M Switchenko; Anees Dhabbaan; Michael Goodman; Mary Jo Lechowicz; Christopher R Flowers; Mohammad K Khan Journal: Int J Radiat Oncol Biol Phys Date: 2015-02-07 Impact factor: 7.038