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Literature DB >> 33332001

Neuromolecular Mechanisms of Cannabis Action.

Abstract

Most of our current understanding of the neuromolecular mechanisms of Cannabis action focusses on two plant cannabinoids, THC and CBD. THC acts primarily through presynaptic CB cannabinoid receptors to regulate neurotransmitter release in the brain, spinal cord and peripheral nerves. CBD action, on the other hand, is probably mediated through multiple molecular targets.

Entities: Chemical

Keywords: cannabidiol; cannabinoid receptors; Δ9-Tetrahydrocannabinol

Year: 2021 PMID： 33332001 DOI： 10.1007/978-3-030-57369-0_2

Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622

119 in total

Review 1. CB2: a cannabinoid receptor with an identity crisis.

Authors: Brady K Atwood; Ken Mackie
Journal: Br J Pharmacol Date: 2010-06 Impact factor: 8.739

Review 2. The role of endocannabinoids in gonadal function and fertility along the evolutionary axis.

Authors: Natalia Battista; Rosaria Meccariello; Gilda Cobellis; Silvia Fasano; Monia Di Tommaso; Valentina Pirazzi; Justin C Konje; Riccardo Pierantoni; Mauro Maccarrone
Journal: Mol Cell Endocrinol Date: 2012-01-25 Impact factor: 4.102

3. The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice.

Authors: Daniele Bolognini; Barbara Costa; Sabatino Maione; Francesca Comelli; Pietro Marini; Vincenzo Di Marzo; Daniela Parolaro; Ruth A Ross; Lisa A Gauson; Maria G Cascio; Roger G Pertwee
Journal: Br J Pharmacol Date: 2010-06 Impact factor: 8.739

4. Direct inhibition by cannabinoids of human 5-HT3A receptors: probable involvement of an allosteric modulatory site.

Authors: M Barann; G Molderings; M Brüss; H Bönisch; B W Urban; M Göthert
Journal: Br J Pharmacol Date: 2002-11 Impact factor: 8.739

5. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.

Authors: T Bisogno; L Hanus; L De Petrocellis; S Tchilibon; D E Ponde; I Brandi; A S Moriello; J B Davis; R Mechoulam; V Di Marzo
Journal: Br J Pharmacol Date: 2001-10 Impact factor: 8.739

6. The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration.

Authors: John C Ashton; Michelle Glass
Journal: Curr Neuropharmacol Date: 2007 Impact factor: 7.363

7. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation.

Authors: D Bolognini; E M Rock; N L Cluny; M G Cascio; C L Limebeer; M Duncan; C G Stott; F A Javid; L A Parker; R G Pertwee
Journal: Br J Pharmacol Date: 2013-03 Impact factor: 8.739

Neuromolecular Mechanisms of Cannabis Action.

Review 1. CB2: a cannabinoid receptor with an identity crisis.

Review 2. The role of endocannabinoids in gonadal function and fertility along the evolutionary axis.

3. The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice.

4. Direct inhibition by cannabinoids of human 5-HT3A receptors: probable involvement of an allosteric modulatory site.

5. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.

6. The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration.

7. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation.

8. n-3 polyunsaturated N-acylethanolamines are CB₂ cannabinoid receptor-preferring endocannabinoids.

Review 9. Cannabis sativa: The Plant of the Thousand and One Molecules.

10. Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression.

1. Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating.