| Literature DB >> 33331176 |
Yan Xiong1,2,3, Ping Yi1,2, Yuhuan Li4, Rongmei Gao4, Junlei Chen1,2, Zhanxing Hu1,2, Huayong Lou1,2, Caixia Du1,2, Jiayu Zhang1,2, Yu Zhang5, Chunmao Yuan1,2, Liejun Huang1,2, Xiaojiang Hao1,2,5, Wei Gu1,2.
Abstract
Phytochemical studies led to the isolation of five new sesquiterpeniod esters, named balsamiferine N-R, along with ten known compounds (6-15) from the leaves of Blumea balsamifera (L.) DC. The skeletons of nine known sesquiterpeniods belong to guaiane and eudesmane. The structures of the new compounds including their absolute configurations were elucidated by comprehensive spectroscopic analysis, and quantum-chemical electronic circular dichroism (ECD) calculation. Compounds 3 and 4 showed significant inhibitory effects on influenza A virus (H3N2) with IC50 values of 46.23 μg/mL and 38.49 μg/mL, respectively. It was the first report on the anti-influenza A virus constituents from B. balsamifera.Entities:
Keywords: Asteraceae; Blumea balsamifera (L.) DC.; anti-influenza virus activity; sesquiterpeniod esters
Mesh：
Substances：
Year: 2020 PMID： 33331176 DOI： 10.1080/14786419.2020.1861615
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861