Chronic myelogenous leukaemia: a model for human cancers.

In this chapter I reviewed the biological and molecular abnormalities associated with CML and related disorders. Much is known about this disease and it is probably not an overstatement to say that there are more data regarding the molecular and biological events underlying CML than any other human cancer. Nevertheless, this review emphasizes how inadequate these data are in explaining most of the important aspects of this disorder. Thus, if CML is to be used as a model of other cancers, much work remains to be done.