| Literature DB >> 33327793 |
Luiz Alexandre Chisini1,2, Mariana Gonzalez Cademartori3, Marucs Cristian Muniz Conde1, Francine Dos Santos Costa1, Luciana Tovo-Rodrigues4, Rodrigo Varella de Carvalho5, Flávio Fernando Demarco2, Marcos Britto Correa2.
Abstract
The aim of this systematic review and meta-analysis was to pool the data on Single Nucleotide Polymorphisms (SNPs) in immune response genes associated with dental caries. Nineteen studies were included in the review and 18 in the meta-analysis. Twenty-two SNPs were evaluated, which are linked to six different genes (MBL2, LFT, MASP2, DEFB1, FCN2 and MUC5B). Most SNPs (81.8%) are related to the possible functional impact on protein coding. The MBL2 gene was associated with caries experience in the analysis of the homozygote (OR = 2.12 CI95%[1.12-3.99]) and heterozygote (OR = 2.22 CI95%[1.44-3.44]) genotypes. The MUC5B gene was associated according to an analysis of the heterozygous genotype (OR = 1.83 CI95%[1.08-3.09]). Thus, SNPs related to immune response genes are linked to the phenotype of caries experience. Although the meta-analysis showed that the genes MBL2 and MUC5B were associated with caries, these results should be interpreted with caution due to the quality of the evidence.Entities:
Keywords: Cariogenic; DMFT; genetics; immune system; oral habits
Year: 2020 PMID： 33327793 DOI： 10.1080/08927014.2020.1856821
Source DB: PubMed Journal: Biofouling ISSN： 0892-7014 Impact factor: 3.209