Literature DB >> 33326790

Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice.

Levi Todd1, Connor Finkbeiner1, Claire K Wong1, Marcus J Hooper1, Thomas A Reh2.   

Abstract

The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that in mice, microglia inhibit the Ascl1-mediated retinal regeneration, suggesting that the innate immune system limits the regenerative response to injury.
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Muller glia; glia; glial reprogramming; microglia; neurogenesis; regeneration; retina; retinal inflammation

Mesh：

Substances：

Year:  2020        PMID： 33326790     DOI： 10.1016/j.celrep.2020.108507

Source DB:  PubMed          Journal:  Cell Rep            Impact factor:   9.423


  16 in total

1.  Microglial depletion abolishes ischemic preconditioning in white matter.

Authors:  Margaret A Hamner; Ashley McDonough; Davin C Gong; Levi J Todd; German Rojas; Sibylle Hodecker; Christopher B Ransom; Thomas A Reh; Bruce R Ransom; Jonathan R Weinstein
Journal:  Glia       Date:  2021-12-23       Impact factor: 7.452

2.  Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors.

Authors:  Levi Todd; Marcus J Hooper; Alexandra K Haugan; Connor Finkbeiner; Nikolas Jorstad; Nicholas Radulovich; Claire K Wong; Phoebe C Donaldson; Wesley Jenkins; Qiang Chen; Fred Rieke; Thomas A Reh
Journal:  Cell Rep       Date:  2021-10-19       Impact factor: 9.423

3.  LRLoop: A method to predict feedback loops in cell-cell communication.

Authors:  Ying Xin; Pin Lyu; Junyao Jiang; Fengquan Zhou; Jie Wang; Seth Blackshaw; Jiang Qian
Journal:  Bioinformatics       Date:  2022-07-05       Impact factor: 6.931

4.  Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy.

Authors:  Joseph Fogerty; Ping Song; Patrick Boyd; Sarah E Grabinski; Thanh Hoang; Adrian Reich; Lauren T Cianciolo; Seth Blackshaw; Jeff S Mumm; David R Hyde; Brian D Perkins
Journal:  J Neurosci       Date:  2022-06-07       Impact factor: 6.709

5.  Compensatory engulfment and Müller glia reactivity in the absence of microglia.

Authors:  Whitney A Thiel; Zachary I Blume; Diana M Mitchell
Journal:  Glia       Date:  2022-04-21       Impact factor: 8.073

6.  NFkB-signaling promotes glial reactivity and suppresses Müller glia-mediated neuron regeneration in the mammalian retina.

Authors:  Isabella Palazzo; Levi J Todd; Thanh V Hoang; Thomas A Reh; Seth Blackshaw; Andy J Fischer
Journal:  Glia       Date:  2022-04-07       Impact factor: 8.073

7.  Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish.

Authors:  Evin Magner; Pamela Sandoval-Sanchez; Ashley C Kramer; Ryan Thummel; Peter F Hitchcock; Scott M Taylor
Journal:  Mol Neurobiol       Date:  2022-03-04       Impact factor: 5.682

8.  Fatty acid-binding proteins and fatty acid synthase influence glial reactivity and promote the formation of Müller glia-derived progenitor cells in the chick retina.

Authors:  Warren A Campbell; Allen Tangeman; Heithem M El-Hodiri; Evan C Hawthorn; Maddie Hathoot; Sydney Blum; Thanh Hoang; Seth Blackshaw; Andy J Fischer
Journal:  Development       Date:  2022-03-04       Impact factor: 6.862

9.  Nuclear Factor I in neurons, glia and during the formation of Müller glia-derived progenitor cells in avian, porcine and primate retinas.

Authors:  Heithem M El-Hodiri; Warren A Campbell; Lisa E Kelly; Evan C Hawthorn; Maura Schwartz; Archana Jalligampala; Maureen A McCall; Kathrin Meyer; Andy J Fischer
Journal:  J Comp Neurol       Date:  2021-12-15       Impact factor: 3.215

10.  Cannabinoid signaling promotes the de-differentiation and proliferation of Müller glia-derived progenitor cells.

Authors:  Warren A Campbell; Sydney Blum; Alana Reske; Thanh Hoang; Seth Blackshaw; Andy J Fischer
Journal:  Glia       Date:  2021-07-07       Impact factor: 8.073
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