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Literature DB >> 33326687

The riddle of the Sphinx: why sphingosine-1-phosphate may help define molecular mechanisms underlying risk stratification for serious COVID-19 infections.

Abstract

The sphingosine-1-phosphate (S1P) is a lysophospholipid signaling molecule with important functions in many physiological and pathological conditions, including viral infection. In this issue of EMBO Molecular Medicine, Marfia et al present a risk stratification based on S1P serum level as a novel prognostic indicator for COVID-19 severity.

Entities: Chemical Disease Gene Species

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Year: 2020 PMID： 33326687 PMCID： PMC7799363 DOI： 10.15252/emmm.202013533

Source DB: PubMed Journal: EMBO Mol Med ISSN： 1757-4676 Impact factor: 12.137

5 in total

Review 1. Sphingosine-1-phosphate and its receptors: structure, signaling, and influence.

Authors: Hugh Rosen; Raymond C Stevens; Michael Hanson; Edward Roberts; Michael B A Oldstone
Journal: Annu Rev Biochem Date: 2013-03-18 Impact factor: 23.643

2. Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection.

Authors: John R Teijaro; Kevin B Walsh; Stephanie Rice; Hugh Rosen; Michael B A Oldstone
Journal: Proc Natl Acad Sci U S A Date: 2014-02-26 Impact factor: 11.205

3. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.

Authors: John R Teijaro; Sean Studer; Nora Leaf; William B Kiosses; Nhan Nguyen; Kosuke Matsuki; Hideo Negishi; Tadatsugu Taniguchi; Michael B A Oldstone; Hugh Rosen
Journal: Proc Natl Acad Sci U S A Date: 2016-01-19 Impact factor: 11.205

Review 4. Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule.

Authors: Michael B A Oldstone; Hugh Rosen
Journal: Curr Top Microbiol Immunol Date: 2014 Impact factor: 4.291

5. Decreased serum level of sphingosine-1-phosphate: a novel predictor of clinical severity in COVID-19.

Authors: Giovanni Marfia; Stefania Navone; Laura Guarnaccia; Rolando Campanella; Michele Mondoni; Marco Locatelli; Alessandra Barassi; Laura Fontana; Fabrizio Palumbo; Emanuele Garzia; Giuseppe Ciniglio Appiani; Davide Chiumello; Monica Miozzo; Stefano Centanni; Laura Riboni
Journal: EMBO Mol Med Date: 2020-12-09 Impact factor: 14.260

5 in total

3 in total

The riddle of the Sphinx: why sphingosine-1-phosphate may help define molecular mechanisms underlying risk stratification for serious COVID-19 infections.

Review 1. Sphingosine-1-phosphate and its receptors: structure, signaling, and influence.

2. Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection.

3. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.

Review 4. Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule.

5. Decreased serum level of sphingosine-1-phosphate: a novel predictor of clinical severity in COVID-19.

1. Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up.

Review 2. Inflammatory pathways in COVID-19: Mechanism and therapeutic interventions.

Review 3. Sphingolipids as Modulators of SARS-CoV-2 Infection.