Literature DB >> 33326092

Liquid Biopsies in Ewing Sarcoma.

Manuela Krumbholz1, Markus Metzler2.   

Abstract

Liquid biopsies enable noninvasive therapy monitoring in patients with solid tumors. Specific serum markers such as proteins, hormones, or enzymes released from tumor cells or in response to tumor growth can be used for quantification of the tumor burden. However, only a fraction of pediatric tumors has none of these serum markers, but tumor-specific genetic alterations represent reliable alternatives. Here we describe a method for using genomic fusion sequences as liquid biopsy markers in Ewing sarcoma patients.

Entities:  

Keywords:  Cell-free circulating DNA; Double-quenched probes; Droplet digital PCR; Ewing sarcoma; Genomic fusion sequences; Liquid biopsy; Serum marker

Mesh：

Substances：

Year:  2021        PMID： 33326092     DOI： 10.1007/978-1-0716-1020-6_4

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  10 in total

1.  Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.

Authors:  O Delattre; J Zucman; B Plougastel; C Desmaze; T Melot; M Peter; H Kovar; I Joubert; P de Jong; G Rouleau
Journal:  Nature       Date:  1992-09-10       Impact factor: 49.962

2.  Highly personalized detection of minimal Ewing sarcoma disease burden from plasma tumor DNA.

Authors:  Masanori Hayashi; David Chu; Christian F Meyer; Nicolas J Llosa; Gregory McCarty; Carol D Morris; Adam S Levin; Jean-Paul Wolinsky; Catherine M Albert; Diana A Steppan; Ben Ho Park; David M Loeb
Journal:  Cancer       Date:  2016-06-28       Impact factor: 6.860

3.  Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients.

Authors:  Peiyong Jiang; Carol W M Chan; K C Allen Chan; Suk Hang Cheng; John Wong; Vincent Wai-Sun Wong; Grace L H Wong; Stephen L Chan; Tony S K Mok; Henry L Y Chan; Paul B S Lai; Rossa W K Chiu; Y M Dennis Lo
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-02       Impact factor: 11.205

Review 4.  Promiscuous partnerships in Ewing's sarcoma.

Authors:  Savita Sankar; Stephen L Lessnick
Journal:  Cancer Genet       Date:  2011-07

5.  First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.

Authors:  Isabella V Miller; Graca Raposo; Ulrich Welsch; Olivia Prazeres da Costa; Uwe Thiel; Maria Lebar; Martina Maurer; Hans-Ulrich Bender; Irene von Luettichau; Günther H S Richter; Stefan Burdach; Thomas G P Grunewald
Journal:  Biol Cell       Date:  2013-05-04       Impact factor: 4.458

6.  Genomic EWSR1 Fusion Sequence as Highly Sensitive and Dynamic Plasma Tumor Marker in Ewing Sarcoma.

Authors:  Manuela Krumbholz; Julia Hellberg; Benedikt Steif; Tobias Bäuerle; Clarissa Gillmann; Torsten Fritscher; Abbas Agaimy; Benjamin Frey; Joerg Juengert; Eva Wardelmann; Wolfgang Hartmann; Heribert Juergens; Uta Dirksen; Markus Metzler
Journal:  Clin Cancer Res       Date:  2016-06-09       Impact factor: 12.531

7.  Tumor-Educated Platelets as Liquid Biopsy in Cancer Patients.

Authors:  Simon A Joosse; Klaus Pantel
Journal:  Cancer Cell       Date:  2015-11-09       Impact factor: 31.743

8.  Ewing sarcoma cells secrete EWS/Fli-1 fusion mRNA via microvesicles.

Authors:  Masanori Tsugita; Nami Yamada; Shunsuke Noguchi; Kazunari Yamada; Hiroshi Moritake; Katsuji Shimizu; Yukihiro Akao; Takatoshi Ohno
Journal:  PLoS One       Date:  2013-10-04       Impact factor: 3.240

9.  Genomic EWS-FLI1 fusion sequences in Ewing sarcoma resemble breakpoint characteristics of immature lymphoid malignancies.

Authors:  Manfred Berger; Uta Dirksen; Andreas Braeuninger; Gabriele Koehler; Heribert Juergens; Manuela Krumbholz; Markus Metzler
Journal:  PLoS One       Date:  2013-02-18       Impact factor: 3.240

10.  Detection of circulating tumor cells in liquid biopsy from Ewing sarcoma patients.

Authors:  Stefania Benini; Gabriella Gamberi; Stefania Cocchi; Jessica Garbetta; Laurent Alberti; Alberto Righi; Marco Gambarotti; Piero Picci; Stefano Ferrari
Journal:  Cancer Manag Res       Date:  2018-01-09       Impact factor: 3.989
  10 in total
  1 in total

1.  Clinical implementation of plasma cell-free circulating tumor DNA quantification by digital droplet PCR for the monitoring of Ewing sarcoma in children and adolescents.

Authors:  Markus G Seidel; Karl Kashofer; Tina Moser; Andrea Thueringer; Bernadette Liegl-Atzwanger; Andreas Leithner; Joanna Szkandera; Martin Benesch; Amin El-Heliebi; Ellen Heitzer
Journal:  Front Pediatr       Date:  2022-08-15       Impact factor: 3.569
  1 in total

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