Barbara Heude1, Pauline Scherdel2, Andreas Werner3, Morgane Le Guern1, Nathalie Gelbert4, Déborah Walther1, Michel Arnould5, Marc Bellaïche6, Bertrand Chevallier7, Jacques Cheymol8, Emmanuel Jobez9, Sylvie N'Guyen10, Christine Pietrement11, Rachel Reynaud12, Jean-François Salaün13, Babak Khoshnood14, Jennifer Zeitlin14, Jean Maccario15, Gérard Breart14, Jean-Christophe Thalabard16, Marie-Aline Charles1, Jérémie Botton17, Bruno Frandji18, Martin Chalumeau19. 1. Early Life Origins of Health Research Team, Université de Paris, Paris, France. 2. Early Life Origins of Health Research Team, Université de Paris, Paris, France; Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Université de Paris, Paris, France. Electronic address: pauline.scherdel@inserm.fr. 3. Association Française de Pédiatrie Ambulatoire, Commission Recherche, Pediatric office, Villeneuve-lès-Avignon, France. 4. Association Française de Pédiatrie Ambulatoire, Commission Recherche, Pediatric Office, Chambéry, France. 5. Société Française de Médecine Générale, Issy les Moulineaux, France. 6. Groupe Francophone d'Hépato-Gastroentérologie et Nutrition Pédiatriques, Department of Pediatric Gastroenterology and Nutrition, Robert-Debré Hospital, AP-HP, Paris, France. 7. Groupe de Pédiatrie Générale-Société Française de Pédiatrie, Department of Pediatrics and Pediatric Emergency, Ambroise-Paré hospital, Boulogne-Billancourt, France. 8. Commission de Santé Publique et de Pédiatrie Sociale-Société Française de Pédiatrie, Clichy, France. 9. Société de Formation Thérapeutique du Généraliste, Commission Recherche, Paris, France. 10. Société Française de Neurologie Pédiatrique, Department of Pediatric Neurology, CHRU, Lille, France. 11. Société de Néphrologie Pédiatrique, Department of Pediatrics-Nephrology Unit, University Hospital of Reims, Faculty of Medicine, Reims, France. 12. Société Française d'Endocrinologie et Diabétologie Pédiatrique, Pediatric Multidisciplinary Department, Endocrinology and Diabetology Unit, APHM, M, U 1251, Aix Marseille UnivINSERM, Marseille, France. 13. Association Française de Pédiatrie Ambulatoire, Commission Recherche, Pediatric office, Saint Brieuc, France. 14. Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Université de Paris, Paris, France. 15. Laboratoire de Biomathématiques, Faculté de Pharmacie, Paris Descartes University, Paris, France. 16. Laboratoire Mathématiques Appliquées à Paris 5, CNRS UMR 8145, Paris Descartes University, Paris, France. 17. Faculty of Pharmacy, Univ Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France. 18. CompuGroup Medical France, Nanterre, France. 19. Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Université de Paris, Paris, France; Inserm, UMR 1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center and Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades Hospital, AP-HP, Université de Paris, Paris, France.
Abstract
BACKGROUND: Both national and WHO growth charts have been found to be poorly calibrated with the physical growth of children in many countries. We aimed to generate new national growth charts for French children in the context of huge datasets of physical growth measurements routinely collected by office-based health practitioners. METHODS: We recruited 32 randomly sampled primary care paediatricians and ten volunteer general practitioners from across the French metropolitan territory who used the same electronic medical records software, from which we extracted all physical growth data for the paediatric patients, with anonymisation. We included measurements from all children born from Jan 1, 1990, and aged 1 month to 18 years by Feb 8, 2018, with birthweight greater than 2500 g, to which an automated process of data cleaning developed to detect and delete measurement or transcription errors was applied. Growth charts for weight and height were derived by using generalised additive models for location, scale, and shape with the Box-Cox power exponential distribution. We compared the new charts to WHO growth charts and existing French national growth charts, and validated our charts using growth data from recent national cross-sectional surveys. FINDINGS: After data cleaning, we included 1 458 468 height and 1 690 340 weight measurements from 238 102 children. When compared with the existing French national and WHO growth charts, all height SD and weight percentile curves for the new growth charts were distinctly above those for the existing French national growth charts, as early as age 1 month, with an average difference of -0·75 SD for height and -0·50 SD for weight for both sexes. Comparison with national cross-sectional surveys showed satisfactory calibration, with generally good fit for children aged 5-6 years and 10-11 years in height and weight and small differences at age 14-15 years. INTERPRETATION: We successfully produced calibrated paediatric growth charts by using a novel big-data approach applied to data routinely collected in clinical practice that could be used in many fields other than anthropometry. FUNDING: The French Ministry of Health; Laboratoires Guigoz-General Pediatrics section of the French Society of Pediatrics-Pediatric Epidemiological Research Group; and the French Association for Ambulatory Pediatrics.
BACKGROUND: Both national and WHO growth charts have been found to be poorly calibrated with the physical growth of children in many countries. We aimed to generate new national growth charts for French children in the context of huge datasets of physical growth measurements routinely collected by office-based health practitioners. METHODS: We recruited 32 randomly sampled primary care paediatricians and ten volunteer general practitioners from across the French metropolitan territory who used the same electronic medical records software, from which we extracted all physical growth data for the paediatric patients, with anonymisation. We included measurements from all children born from Jan 1, 1990, and aged 1 month to 18 years by Feb 8, 2018, with birthweight greater than 2500 g, to which an automated process of data cleaning developed to detect and delete measurement or transcription errors was applied. Growth charts for weight and height were derived by using generalised additive models for location, scale, and shape with the Box-Cox power exponential distribution. We compared the new charts to WHO growth charts and existing French national growth charts, and validated our charts using growth data from recent national cross-sectional surveys. FINDINGS: After data cleaning, we included 1 458 468 height and 1 690 340 weight measurements from 238 102 children. When compared with the existing French national and WHO growth charts, all height SD and weight percentile curves for the new growth charts were distinctly above those for the existing French national growth charts, as early as age 1 month, with an average difference of -0·75 SD for height and -0·50 SD for weight for both sexes. Comparison with national cross-sectional surveys showed satisfactory calibration, with generally good fit for children aged 5-6 years and 10-11 years in height and weight and small differences at age 14-15 years. INTERPRETATION: We successfully produced calibrated paediatric growth charts by using a novel big-data approach applied to data routinely collected in clinical practice that could be used in many fields other than anthropometry. FUNDING: The French Ministry of Health; Laboratoires Guigoz-General Pediatrics section of the French Society of Pediatrics-Pediatric Epidemiological Research Group; and the French Association for Ambulatory Pediatrics.
Authors: Manon Bergerat; Barbara Heude; Marion Taine; Sylvie Nguyen The Tich; Andreas Werner; Bruno Frandji; Thomas Blauwblomme; Dorin Sumanaru; Marie-Aline Charles; Martin Chalumeau; Pauline Scherdel Journal: Lancet Reg Health Eur Date: 2021-05-05
Authors: R A I Bethlehem; J Seidlitz; S R White; J W Vogel; K M Anderson; C Adamson; S Adler; G S Alexopoulos; E Anagnostou; A Areces-Gonzalez; D E Astle; B Auyeung; M Ayub; J Bae; G Ball; S Baron-Cohen; R Beare; S A Bedford; V Benegal; F Beyer; J Blangero; M Blesa Cábez; J P Boardman; M Borzage; J F Bosch-Bayard; N Bourke; V D Calhoun; M M Chakravarty; C Chen; C Chertavian; G Chetelat; Y S Chong; J H Cole; A Corvin; M Costantino; E Courchesne; F Crivello; V L Cropley; J Crosbie; N Crossley; M Delarue; R Delorme; S Desrivieres; G A Devenyi; M A Di Biase; R Dolan; K A Donald; G Donohoe; K Dunlop; A D Edwards; J T Elison; C T Ellis; J A Elman; L Eyler; D A Fair; E Feczko; P C Fletcher; P Fonagy; C E Franz; L Galan-Garcia; A Gholipour; J Giedd; J H Gilmore; D C Glahn; I M Goodyer; P E Grant; N A Groenewold; F M Gunning; R E Gur; R C Gur; C F Hammill; O Hansson; T Hedden; A Heinz; R N Henson; K Heuer; J Hoare; B Holla; A J Holmes; R Holt; H Huang; K Im; J Ipser; C R Jack; A P Jackowski; T Jia; K A Johnson; P B Jones; D T Jones; R S Kahn; H Karlsson; L Karlsson; R Kawashima; E A Kelley; S Kern; K W Kim; M G Kitzbichler; W S Kremen; F Lalonde; B Landeau; S Lee; J Lerch; J D Lewis; J Li; W Liao; C Liston; M V Lombardo; J Lv; C Lynch; T T Mallard; M Marcelis; R D Markello; S R Mathias; B Mazoyer; P McGuire; M J Meaney; A Mechelli; N Medic; B Misic; S E Morgan; D Mothersill; J Nigg; M Q W Ong; C Ortinau; R Ossenkoppele; M Ouyang; L Palaniyappan; L Paly; P M Pan; C Pantelis; M M Park; T Paus; Z Pausova; D Paz-Linares; A Pichet Binette; K Pierce; X Qian; J Qiu; A Qiu; A Raznahan; T Rittman; A Rodrigue; C K Rollins; R Romero-Garcia; L Ronan; M D Rosenberg; D H Rowitch; G A Salum; T D Satterthwaite; H L Schaare; R J Schachar; A P Schultz; G Schumann; M Schöll; D Sharp; R T Shinohara; I Skoog; C D Smyser; R A Sperling; D J Stein; A Stolicyn; J Suckling; G Sullivan; Y Taki; B Thyreau; R Toro; N Traut; K A Tsvetanov; N B Turk-Browne; J J Tuulari; C Tzourio; É Vachon-Presseau; M J Valdes-Sosa; P A Valdes-Sosa; S L Valk; T van Amelsvoort; S N Vandekar; L Vasung; L W Victoria; S Villeneuve; A Villringer; P E Vértes; K Wagstyl; Y S Wang; S K Warfield; V Warrier; E Westman; M L Westwater; H C Whalley; A V Witte; N Yang; B Yeo; H Yun; A Zalesky; H J Zar; A Zettergren; J H Zhou; H Ziauddeen; A Zugman; X N Zuo; E T Bullmore; A F Alexander-Bloch Journal: Nature Date: 2022-04-06 Impact factor: 69.504
Authors: Yan Cheng Yang; Saad Ul Islam; Asra Noor; Sadia Khan; Waseem Afsar; Shah Nazir Journal: Comput Math Methods Med Date: 2021-09-06 Impact factor: 2.238