| Literature DB >> 33322404 |
Rodrigo Pinheiro Araldi1,2,3, Fernanda D'Amelio1, Hugo Vigerelli1, Thatiana Correa de Melo1, Irina Kerkis1,3.
Abstract
The aging population has contributed to the rapid rise in the global incidence of neurodegenerative diseases. Despite the medical advances, there are no effective treatments for these disorders. Therefore, there is an urgent need for new treatments for these diseases. In this sense, cell therapy has been recognized as the best candidate for treating incurable diseases, such as neurodegenerative disorders. However, the therapeutic use of these cells can be limited by several factors. Thus, there has been a rediscovery that extracellular vesicles, including exosomes, can be alternatively explored in the treatment of these diseases, overcoming the limits of cell-based therapy. In this sense, this review aims to revisit all areas from biology, including biogenesis and the content of exosomes, to biotechnology, proposing the minimal information required to isolate, characterize, and study the content of these vesicles for scientific and/or clinical purposes.Entities:
Keywords: cell-free therapy; exosomes; extracellular vesicles; neurodegenerative diseases; stem cell
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Year: 2020 PMID： 33322404 PMCID： PMC7763259 DOI： 10.3390/cells9122663
Source DB: PubMed Journal: Cells ISSN： 2073-4409 Impact factor: 6.600