Literature DB >> 33322263

Ayurveda and Epigenetics.

Hari Sharma1, Robert Keith Wallace2.   

Abstract

Ayurveda is a comprehensive, natural health care system that originated in the ancient Vedic times of India. Epigenetics refers to the external modification of DNA that turns genes on and off, affecting gene expression. This occurs without changes in the basic structure of the DNA. This gene expression can have transgenerational effects. The major factors that cause epigenetic changes are lifestyle and behavior, diet and digestion, stress, and environmental factors. Ayurveda addresses these factors, thereby affecting the Deha (body) Prakriti (psychophysiological constitution), which corresponds to the phenotype, and indirectly the Janma (birth) Prakriti, which corresponds to the genotype. Thus, it is proposed that epigenetics is an important mechanism of Ayurveda. This correlation and understanding will lead to better communication and understanding with the current medical system, and lead to better integration of both sciences in the management of optimal health. In addition, research on Ayurvedic modalities affecting gene expression will further increase correlation and understanding between the current medical system and Ayurveda.

Entities:  

Keywords:  Ayurveda; Prakriti; doshas; epigenetics; genotype; phenotype

Mesh:

Year:  2020        PMID: 33322263      PMCID: PMC7763202          DOI: 10.3390/medicina56120687

Source DB:  PubMed          Journal:  Medicina (Kaunas)        ISSN: 1010-660X            Impact factor:   2.430


  37 in total

1.  Epigenetics: A New Bridge between Nutrition and Health.

Authors:  Sang-Woon Choi; Simonetta Friso
Journal:  Adv Nutr       Date:  2010-11-16       Impact factor: 8.701

2.  Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation.

Authors:  Hong-li Liu; Yan Chen; Guo-hui Cui; Jian-feng Zhou
Journal:  Acta Pharmacol Sin       Date:  2005-05       Impact factor: 6.150

3.  Stress, epigenetics and depression: A systematic review.

Authors:  Caroline Park; Joshua D Rosenblat; Elisa Brietzke; Zihang Pan; Yena Lee; Bing Cao; Hannah Zuckerman; Anastasia Kalantarova; Roger S McIntyre
Journal:  Neurosci Biobehav Rev       Date:  2019-04-18       Impact factor: 8.989

Review 4.  Transgenerational Epigenetics of Traumatic Stress.

Authors:  Ali Jawaid; Martin Roszkowski; Isabelle M Mansuy
Journal:  Prog Mol Biol Transl Sci       Date:  2018-06-11       Impact factor: 3.622

Review 5.  MicroRNA.

Authors:  Thomas X Lu; Marc E Rothenberg
Journal:  J Allergy Clin Immunol       Date:  2017-10-23       Impact factor: 10.793

6.  Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention.

Authors:  Dean Ornish; Mark Jesus M Magbanua; Gerdi Weidner; Vivian Weinberg; Colleen Kemp; Christopher Green; Michael D Mattie; Ruth Marlin; Jeff Simko; Katsuto Shinohara; Christopher M Haqq; Peter R Carroll
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-16       Impact factor: 11.205

7.  Gene expression profiling during intensive cardiovascular lifestyle modification: Relationships with vascular function and weight loss.

Authors:  Heather L Blackburn; Seóna McErlean; Gera L Jellema; Ryan van Laar; Marina N Vernalis; Darrell L Ellsworth
Journal:  Genom Data       Date:  2015-03-12

8.  A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells.

Authors:  Kendra J Royston; Neha Udayakumar; Kayla Lewis; Trygve O Tollefsbol
Journal:  Int J Mol Sci       Date:  2017-05-19       Impact factor: 5.923

9.  The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells.

Authors:  Kelly Hallman; Katie Aleck; Brigitte Dwyer; Victoria Lloyd; Meghan Quigley; Nada Sitto; Amy E Siebert; Sumi Dinda
Journal:  Breast Cancer (Dove Med Press)       Date:  2017-03-10

10.  Meditation: Process and effects.

Authors:  Hari Sharma
Journal:  Ayu       Date:  2015 Jul-Sep
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  2 in total

Review 1.  An Ayurgenomics Approach: Prakriti-Based Drug Discovery and Development for Personalized Care.

Authors:  Zoufang Huang; Vivek P Chavda; Rajashri Bezbaruah; Vladimir N Uversky; Sucharitha P; Aayushi B Patel; Zhe-Sheng Chen
Journal:  Front Pharmacol       Date:  2022-04-01       Impact factor: 5.810

2.  The Future of Medicine: Frontiers in Integrative Health and Medicine.

Authors:  Mahadevan Seetharaman; Geetha Krishnan; Robert H Schneider
Journal:  Medicina (Kaunas)       Date:  2021-11-28       Impact factor: 2.430

  2 in total

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