Literature DB >> 33322223

TRPML1-Emerging Roles in Cancer.

Yiming Yang1, Xingjian Zhai1, Yassine El Hiani1.   

Abstract

The mucolipin-1 (TRPML1) channel maintains lysosomal ionic homeostasis and regulates autophagic flux. Defects of TRPML1 lead to lysosomal storage diseases and neurodegeneration. In this report, we discuss emerging evidence pertaining to differential regulation of TRPML1 signaling pathways in cancer progression with the goal of leveraging the oncogenic potential of TRPML1 to inspire therapeutic interventions.

Entities:  

Keywords:  TRPML1; cancer; lysosomes; mitochondria

Mesh：

Substances：

Year:  2020        PMID： 33322223      PMCID： PMC7763474          DOI： 10.3390/cells9122682

Source DB:  PubMed          Journal:  Cells        ISSN： 2073-4409            Impact factor:   6.600


  31 in total

1.  Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.

Authors:  Michela Palmieri; Soren Impey; Hyojin Kang; Alberto di Ronza; Carl Pelz; Marco Sardiello; Andrea Ballabio
Journal:  Hum Mol Genet       Date:  2011-07-13       Impact factor: 6.150

2.  Abnormal electroretinogram from a Drosophila mutant.

Authors:  D J Cosens; A Manning
Journal:  Nature       Date:  1969-10-18       Impact factor: 49.962

3.  Transcriptional activation of lysosomal exocytosis promotes cellular clearance.

Authors:  Diego L Medina; Alessandro Fraldi; Valentina Bouche; Fabio Annunziata; Gelsomina Mansueto; Carmine Spampanato; Claudia Puri; Antonella Pignata; Jose A Martina; Marco Sardiello; Michela Palmieri; Roman Polishchuk; Rosa Puertollano; Andrea Ballabio
Journal:  Dev Cell       Date:  2011-09-01       Impact factor: 12.270

4.  MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.

Authors:  Xiaoli Zhang; Xiping Cheng; Lu Yu; Junsheng Yang; Raul Calvo; Samarjit Patnaik; Xin Hu; Qiong Gao; Meimei Yang; Maria Lawas; Markus Delling; Juan Marugan; Marc Ferrer; Haoxing Xu
Journal:  Nat Commun       Date:  2016-06-30       Impact factor: 14.919

5.  Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression.

Authors:  Maria Beatrice Morelli; Massimo Nabissi; Consuelo Amantini; Daniele Tomassoni; Francesco Rossi; Claudio Cardinali; Matteo Santoni; Antonietta Arcella; Maria Antonietta Oliva; Angela Santoni; Carlo Polidori; Maria Paola Mariani; Giorgio Santoni
Journal:  Oncotarget       Date:  2016-07-12

6.  MCOLN1 Promotes Proliferation and Predicts Poor Survival of Patients with Pancreatic Ductal Adenocarcinoma.

Authors:  Zhan-Dong Hu; Jun Yan; Kai-Yue Cao; Zhi-Qi Yin; Wei-Wei Xin; Ming-Fang Zhang
Journal:  Dis Markers       Date:  2019-08-05       Impact factor: 3.434

Review 7.  Targeting Proteotoxic Stress in Cancer: A Review of the Role that Protein Quality Control Pathways Play in Oncogenesis.

Authors:  Matthew Ho Zhi Guang; Emma L Kavanagh; Luke Paul Dunne; Paul Dowling; Li Zhang; Sinéad Lindsay; Despina Bazou; Chia Yin Goh; Cathal Hanley; Giada Bianchi; Kenneth C Anderson; Peter O'Gorman; Amanda McCann
Journal:  Cancers (Basel)       Date:  2019-01-09       Impact factor: 6.639

8.  TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling.

Authors:  Stacy Y Kasitinon; Ugur Eskiocak; Misty Martin; Divya Bezwada; Vishal Khivansara; Alpaslan Tasdogan; Zhiyu Zhao; Thomas Mathews; Arin B Aurora; Sean J Morrison
Journal:  Cell Rep       Date:  2019-08-27       Impact factor: 9.423

Review 9.  Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases.

Authors:  Giorgio Santoni; Federica Maggi; Consuelo Amantini; Oliviero Marinelli; Massimo Nabissi; Maria Beatrice Morelli
Journal:  Front Physiol       Date:  2020-03-24       Impact factor: 4.566

Review 10.  Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation.

Authors:  Harold A Silverman; Adrian Chen; Nigel L Kravatz; Sangeeta S Chavan; Eric H Chang
Journal:  Front Immunol       Date:  2020-10-23       Impact factor: 7.561
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.