| Literature DB >> 33322198 |
Sk Sarif Hassan1, Shinjini Ghosh2, Diksha Attrish3, Pabitra Pal Choudhury4, Alaa A A Aljabali5, Bruce D Uhal6, Kenneth Lundstrom7, Nima Rezaei8,9, Vladimir N Uversky10, Murat Seyran11, Damiano Pizzol12, Parise Adadi13, Antonio Soares14, Tarek Mohamed Abd El-Aziz14,15, Ramesh Kandimalla16,17, Murtaza M Tambuwala18, Gajendra Kumar Azad19, Samendra P Sherchan20, Wagner Baetas-da-Cruz21, Kazuo Takayama22, Ángel Serrano-Aroca23, Gaurav Chauhan24, Giorgio Palu25, Adam M Brufsky26.
Abstract
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.Entities:
Keywords: ACE2; SARS-CoV-2; bioinformatics; transmission; viral spike receptor-binding domain
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Year: 2020 PMID： 33322198 PMCID： PMC7763092 DOI： 10.3390/molecules25245906
Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.411