Literature DB >> 33321955

Therapeutic Effects of Specialized Pro-Resolving Lipids Mediators on Cardiac Fibrosis via NRF2 Activation.

Gyeoung Jin Kang1, Eun Ji Kim1,2, Chang Hoon Lee2.   

Abstract

Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis. In order to control such oxidative stress, the importance of nuclear factor erythropoietin 2 related factor 2 (NRF2) has recently been highlighted. In this review, we will discuss the activation of NRF2 by docosahexanoic acid (DHA), eicosapentaenoic acid (EPA), and the specialized pro-resolving lipid mediators (SPMs) derived from polyunsaturated lipids, including DHA and EPA. Additionally, we will discuss their effects on cardiac fibrosis via NRF2 activation.

Entities:  

Keywords:  NRF2; cardiac fibrosis; lipoxins; maresins; neuroprotectins; resolvins

Year:  2020        PMID： 33321955      PMCID： PMC7764646          DOI： 10.3390/antiox9121259

Source DB:  PubMed          Journal:  Antioxidants (Basel)        ISSN： 2076-3921


  207 in total

1.  Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor.

Authors:  R D Ye; S L Cavanagh; O Quehenberger; E R Prossnitz; C G Cochrane
Journal:  Biochem Biophys Res Commun       Date:  1992-04-30       Impact factor: 3.575

2.  Characterization of the promoter and the transcriptional regulation of the lipoxin A4 receptor (FPR2/ALX) gene in human monocytes and macrophages.

Authors:  Vanessa Waechter; Mattia Schmid; Magdalena Herova; Angelika Weber; Viola Günther; Jacqueline Marti-Jaun; Sophia Wüst; Marian Rösinger; Claudio Gemperle; Martin Hersberger
Journal:  J Immunol       Date:  2012-01-13       Impact factor: 5.422

Review 3.  Monocyte and macrophage plasticity in tissue repair and regeneration.

Authors:  Amitava Das; Mithun Sinha; Soma Datta; Motaz Abas; Scott Chaffee; Chandan K Sen; Sashwati Roy
Journal:  Am J Pathol       Date:  2015-06-26       Impact factor: 4.307

4.  Docosahexaenoic Acid (DHA) Provides Neuroprotection in Traumatic Brain Injury Models via Activating Nrf2-ARE Signaling.

Authors:  Wei Zhu; Yuexia Ding; Wei Kong; Tuo Li; Hongguang Chen
Journal:  Inflammation       Date:  2018-08       Impact factor: 4.092

5.  Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression.

Authors:  M Crabos; M Roth; A W Hahn; P Erne
Journal:  J Clin Invest       Date:  1994-06       Impact factor: 14.808

6.  Mouse ChemR23 is expressed in dendritic cell subsets and macrophages, and mediates an anti-inflammatory activity of chemerin in a lung disease model.

Authors:  Souphalone Luangsay; Valérie Wittamer; Benjamin Bondue; Olivier De Henau; Laurie Rouger; Maryse Brait; Jean-Denis Franssen; Patricia de Nadai; François Huaux; Marc Parmentier
Journal:  J Immunol       Date:  2009-10-19       Impact factor: 5.422

7.  Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses.

Authors:  Sadani N Cooray; Thomas Gobbetti; Trinidad Montero-Melendez; Simon McArthur; Dawn Thompson; Adrian J L Clark; Roderick J Flower; Mauro Perretti
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-09       Impact factor: 11.205

Review 8.  DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation.

Authors:  Melody G Duvall; Bruce D Levy
Journal:  Eur J Pharmacol       Date:  2015-11-03       Impact factor: 4.432

Review 9.  Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration.

Authors:  Virpi Talman; Heikki Ruskoaho
Journal:  Cell Tissue Res       Date:  2016-06-21       Impact factor: 5.249

10.  Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.

Authors:  Makoto Arita; Francesca Bianchini; Julio Aliberti; Alan Sher; Nan Chiang; Song Hong; Rong Yang; Nicos A Petasis; Charles N Serhan
Journal:  J Exp Med       Date:  2005-03-07       Impact factor: 14.307
View more
  5 in total

1.  Natural Antioxidant in Cardiovascular and Cerebrovascular Diseases.

Authors:  Yi-Sook Jung
Journal:  Antioxidants (Basel)       Date:  2022-06-13

Review 2.  Roles of NRF2 in Fibrotic Diseases: From Mechanisms to Therapeutic Approaches.

Authors:  Wenlong Hao; Minghao Li; Qingmin Cai; Shiying Wu; Xiangyao Li; Quanyu He; Yongbin Hu
Journal:  Front Physiol       Date:  2022-06-03       Impact factor: 4.755

3.  Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation.

Authors:  Almudena Val-Blasco; Patricia Prieto; Rafael Iñigo Jaén; Marta Gil-Fernández; Marta Pajares; Nieves Domenech; Verónica Terrón; María Tamayo; Inmaculada Jorge; Jesús Vázquez; Andrea Bueno-Sen; María Teresa Vallejo-Cremades; Jorge Pombo-Otero; Sergio Sanchez-García; Gema Ruiz-Hurtado; Ana María Gómez; Carlos Zaragoza; María Generosa Crespo-Leiro; Eduardo López-Collazo; Antonio Cuadrado; Carmen Delgado; Lisardo Boscá; María Fernández-Velasco
Journal:  JACC Basic Transl Sci       Date:  2022-05-18

4.  Exercise Training Alleviates Cardiac Fibrosis through Increasing Fibroblast Growth Factor 21 and Regulating TGF-β1-Smad2/3-MMP2/9 Signaling in Mice with Myocardial Infarction.

Authors:  Yixuan Ma; Yixin Kuang; Wenyan Bo; Qiaoqin Liang; Wenfei Zhu; Mengxin Cai; Zhenjun Tian
Journal:  Int J Mol Sci       Date:  2021-11-15       Impact factor: 5.923

Review 5.  Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis.

Authors:  Juan Salazar; Daniela Pirela; Manuel Nava; Ana Castro; Lissé Angarita; Heliana Parra; Samuel Durán-Agüero; Diana Marcela Rojas-Gómez; Néstor Galbán; Roberto Añez; Maricarmen Chacín; Andrea Diaz; Nelson Villasmil; Juan Bautista De Sanctis; Valmore Bermúdez
Journal:  Int J Mol Sci       Date:  2022-03-15       Impact factor: 5.923
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.