Literature DB >> 33321947

Congestive Hepatopathy.

José Ignacio Fortea1,2,3, Ángela Puente1,2,3, Antonio Cuadrado1,2,3, Patricia Huelin1,2,3, Raúl Pellón4, Francisco José González Sánchez4, Marta Mayorga5, María Luisa Cagigal5, Inés García Carrera1, Marina Cobreros1, Javier Crespo1,2,3, Emilio Fábrega1,2,3.   

Abstract

Liver disease resulting from heart failure (HF) has generally been referred as "cardiac hepatopathy". One of its main forms is congestive hepatopathy (CH), which results from passive venous congestion in the setting of chronic right-sided HF. The current spectrum of CH differs from earlier reports with HF, due to ischemic cardiomyopathy and congenital heart disease having surpassed rheumatic valvular disease. The chronic passive congestion leads to sinusoidal hypertension, centrilobular fibrosis, and ultimately, cirrhosis ("cardiac cirrhosis") and hepatocellular carcinoma after several decades of ongoing injury. Contrary to primary liver diseases, in CH, inflammation seems to play no role in the progression of liver fibrosis, bridging fibrosis occurs between central veins to produce a "reversed lobulation" pattern and the performance of non-invasive diagnostic tests of liver fibrosis is poor. Although the clinical picture and prognosis is usually dominated by the underlying heart condition, the improved long-term survival of cardiac patients due to advances in medical and surgical treatments are responsible for the increased number of liver complications in this setting. Eventually, liver disease could become as clinically relevant as cardiac disease and further complicate its management.

Entities:  

Keywords:  cirrhosis; heart failure; heart transplantation; portal hypertension

Year:  2020        PMID: 33321947      PMCID: PMC7764741          DOI: 10.3390/ijms21249420

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN: 1422-0067            Impact factor:   5.923


  122 in total

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