Gaetano Gallo1, Ugo Grossi2, Gian Luca Di Tanna3, Giulio Aniello Santoro2, Gilda De Paola1, Giuseppe Clerico4, Alberto Realis Luc4, Mario Trompetto4, Giuseppe Sammarco5. 1. Department of Medical and Surgical Sciences, University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy. 2. Tertiary Referral Pelvic Floor Center, IV Surgery Unit, Treviso Regional Hospital, DISCOG, University of Padua, 31100 Treviso, Italy. 3. Statistics Division, The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sidney, NSW 2042, Australia. 4. Department of Colorectal Surgery, S. Rita Clinic, 13100 Vercelli, Italy. 5. Department of Health Sciences, University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Abstract
BACKGROUND: Pain is the most common complication after open excisional hemorrhoidectomy (OEH). We assessed the effectiveness of polycarbophil and Propionibacterium acnes lysate gel (Emorsan®Gel) on pain control after OEH. RESEARCH DESIGN AND METHODS: Fifty consecutive patients undergoing OEH were included. All patients received stool softeners and oral analgesia in the post-operative period. Emorsan®Gel was also used topically by the last 25 patients (Emorsan®Gel group (EG)) until Post-Operative Day 20 (POD 20). The primary outcome was the effectiveness of Emorsan®Gel on pain relief using an 11-point visual analogue scale (VAS). Morbidity, wound healing (WH), and time to work were documented at POD 1, POD 10, POD 20, and POD 40. RESULTS: Of the 50 patients enrolled, twenty-eight (56%) were males; median age, 49 (range, 28-73) years. The VAS score decreased over time in all patients, with significantly lower scores at POD 20 in the EG (1.44 (SD, 1.16) vs. 2.12 (0.93) in the control group (CG); p = 0.045). All patients in the EG achieved complete WH at last follow-up, compared to only 17 (68%) in the CG (p = 0.004). The likelihood of WH was 66% higher in the EG (OR, 1.66 [95%CI, 0.80-3.44; p = 0.172). CONCLUSIONS: Emorsan®Gel is safe and effective at reducing pain after EOH, promoting earlier WH compared to standard care treatment.
BACKGROUND:Pain is the most common complication after open excisional hemorrhoidectomy (OEH). We assessed the effectiveness of polycarbophil and Propionibacterium acnes lysate gel (Emorsan®Gel) on pain control after OEH. RESEARCH DESIGN AND METHODS: Fifty consecutive patients undergoing OEH were included. All patients received stool softeners and oral analgesia in the post-operative period. Emorsan®Gel was also used topically by the last 25 patients (Emorsan®Gel group (EG)) until Post-Operative Day 20 (POD 20). The primary outcome was the effectiveness of Emorsan®Gel on pain relief using an 11-point visual analogue scale (VAS). Morbidity, wound healing (WH), and time to work were documented at POD 1, POD 10, POD 20, and POD 40. RESULTS: Of the 50 patients enrolled, twenty-eight (56%) were males; median age, 49 (range, 28-73) years. The VAS score decreased over time in all patients, with significantly lower scores at POD 20 in the EG (1.44 (SD, 1.16) vs. 2.12 (0.93) in the control group (CG); p = 0.045). All patients in the EG achieved complete WH at last follow-up, compared to only 17 (68%) in the CG (p = 0.004). The likelihood of WH was 66% higher in the EG (OR, 1.66 [95%CI, 0.80-3.44; p = 0.172). CONCLUSIONS:Emorsan®Gel is safe and effective at reducing pain after EOH, promoting earlier WH compared to standard care treatment.
Authors: I Giannini; G Pecorella; D Pennisi; G Santangelo; R Digennaro; F Latorre; G Giuliani; D F Altomare Journal: Minerva Chir Date: 2014-04 Impact factor: 1.000
Authors: Lillian C Becker; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; Daniel C Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; F Alan Andersen Journal: Int J Toxicol Date: 2014-05-26 Impact factor: 2.032
Authors: Raffaele Serra; Luca Gallelli; Raffaele Grande; Bruno Amato; Giovanni De Caridi; Giuseppe Sammarco; Francesco Ferrari; Lucia Butrico; Gaetano Gallo; Antonia Rizzuto; Stefano de Franciscis; Rosario Sacco Journal: Surgery Date: 2015-08-08 Impact factor: 3.982