Literature DB >> 33320804

Does lack of brain injury mean lack of cognitive impairment in traumatic spinal cord injury?

Eyal Heled1,2, Keren Tal1, Gabi Zeilig2,3.   

Abstract

OBJECTIVE: Traumatic spinal cord injury (tSCI) has implications in many areas, including cognitive functioning. Findings regarding cognitive problems in people with SCI are inconsistent, presumably due to multiple variables than can affect performance, among them emotional variables. The purpose of the current study was to elucidate cognitive sequalae in some individuals with tSCI with no medical record of brain injury, while taking emotional variables into consideration.
DESIGN: Cross-sectional, with two groups.
SETTING: A public rehabilitation center. PARTICIPANTS: Twenty participants with tSCI at least ten months post injury and twenty non-SCI controls, matched for sex, age, and education. INTERVENTION: None. OUTCOME MEASURES: A battery of neuropsychological tests tapping executive functions, memory, attention, and naming abilities, in addition to questionnaires assessing depression and distress.
RESULTS: When emotional variables were statistically controlled, participants with tSCI showed higher levels of depression and distress and scored lower than non-SCI control participants on all cognitive tests except naming. Executive functions were found to have the highest effect size, though no specific ability was sensitive enough to differentiate between the groups in a binary logistic regression analysis.
CONCLUSION: In some individuals with chronic tSCI, lower cognitive ability that is unrelated to emotional distress might result from spinal cord damage and its implications in a population who's medical records show no indication of brain injury. This highlights the importance of conducting cognitive evaluation following SCI, so that deficits can be effectively addressed during rehabilitation.

Entities:  

Keywords:  Cognitive functions; Depression; Spinal cord injury; Traumatic brain injury

Mesh:

Year:  2020        PMID: 33320804      PMCID: PMC9135427          DOI: 10.1080/10790268.2020.1847564

Source DB:  PubMed          Journal:  J Spinal Cord Med        ISSN: 1079-0268            Impact factor:   2.040


  48 in total

1.  International standards for neurological classification of spinal cord injury (revised 2011).

Authors:  Steven C Kirshblum; Stephen P Burns; Fin Biering-Sorensen; William Donovan; Daniel E Graves; Amitabh Jha; Mark Johansen; Linda Jones; Andrei Krassioukov; M J Mulcahey; Mary Schmidt-Read; William Waring
Journal:  J Spinal Cord Med       Date:  2011-11       Impact factor: 1.985

2.  Examining the effect of spinal cord injury on emotional awareness, expressivity and memory for emotional material.

Authors:  D K Deady; N T North; D Allan; M J Law Smith; R E O'Carroll
Journal:  Psychol Health Med       Date:  2010-08       Impact factor: 2.423

3.  The effects of mild traumatic brain injury on confrontation naming in adults.

Authors:  Irene M Barrow; Monica Hough; Michael P Rastatter; Marianna Walker; Donald Holbert; Michael F Rotondo
Journal:  Brain Inj       Date:  2006-07       Impact factor: 2.311

4.  Traumatic brain injury: from bench to bedside [corrected] to society.

Authors:  Anthony J-W Chen; Mark D'Esposito
Journal:  Neuron       Date:  2010-04-15       Impact factor: 17.173

5.  Chronic pain, depression and quality of life in individuals with spinal cord injury: Mediating role of participation.

Authors:  Rachel Müller; Gunther Landmann; Markus Béchir; Timo Hinrichs; Ursina Arnet; Xavier Jordan; Martin W G Brinkhof
Journal:  J Rehabil Med       Date:  2017-06-28       Impact factor: 2.912

6.  Decision making in patients with spinal cord damage: afferent feedback and the somatic marker hypothesis.

Authors:  N T North; R E O'Carroll
Journal:  Neuropsychologia       Date:  2001       Impact factor: 3.139

7.  Traumatic brain injury in patients with traumatic spinal cord injury: clinical and economic consequences.

Authors:  Cheryl L Bradbury; Walter P Wodchis; David J Mikulis; Ephrem G Pano; Sander L Hitzig; Colleen F McGillivray; Fahad N Ahmad; B Catherine Craven; Robin E Green
Journal:  Arch Phys Med Rehabil       Date:  2008-12       Impact factor: 3.966

8.  NIH EXAMINER: conceptualization and development of an executive function battery.

Authors:  Joel H Kramer; Dan Mungas; Katherine L Possin; Katherine P Rankin; Adam L Boxer; Howard J Rosen; Alan Bostrom; Lena Sinha; Ashley Berhel; Mary Widmeyer
Journal:  J Int Neuropsychol Soc       Date:  2013-10-08       Impact factor: 2.892

9.  Specific Deficit in Implicit Motor Sequence Learning following Spinal Cord Injury.

Authors:  Ayala Bloch; Dror Tamir; Eli Vakil; Gabi Zeilig
Journal:  PLoS One       Date:  2016-06-29       Impact factor: 3.240

10.  The course and prognostic factors of cognitive status after central nervous system trauma: a systematic review protocol.

Authors:  Tatyana Mollayeva; Nicole Pacheco; Andrea D'Souza; Angela Colantonio
Journal:  BMJ Open       Date:  2017-09-18       Impact factor: 2.692

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  2 in total

1.  Hippocampal Mitochondrial Abnormalities Induced the Dendritic Complexity Reduction and Cognitive Decline in a Rat Model of Spinal Cord Injury.

Authors:  Xvlei Hu; Liang Wu; Yujun Wen; Juan Liu; Hailiang Li; Yifan Zhang; Zhihua Wang; Jiangwei Ding; Zhong Zeng; Hechun Xia
Journal:  Oxid Med Cell Longev       Date:  2022-05-04       Impact factor: 7.310

Review 2.  Future Perspectives in Spinal Cord Repair: Brain as Saviour? TSCI with Concurrent TBI: Pathophysiological Interaction and Impact on MSC Treatment.

Authors:  Paul Köhli; Ellen Otto; Denise Jahn; Marie-Jacqueline Reisener; Jessika Appelt; Adibeh Rahmani; Nima Taheri; Johannes Keller; Matthias Pumberger; Serafeim Tsitsilonis
Journal:  Cells       Date:  2021-10-30       Impact factor: 6.600

  2 in total

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