Lu Xu1, Yanpeng Ma2, Shengfeng Wang1, Jingnan Feng1, Lili Liu1, Jinxi Wang3, Guozhen Liu4, Dianrong Xiu2, Wei Fu2, Siyan Zhan1,5,6, Tao Sun2, Pei Gao1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. 2. Department of General Surgery, Peking University Third Hospital, Beijing, China. 3. Shanghai Songsheng Business Consulting Co. Ltd, Beijing, China. 4. Peking University Health Information Technology Co. Ltd, Beijing, China. 5. Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China. 6. Center for Intelligent Public Health, Institute for Artificial Intelligence, Peking University, Beijing, China.
Abstract
BACKGROUND: Information on incidence of gastrointestinal stromal tumor (GIST), the most common type of mesenchymal tumor in gastrointestinal tract, was limited in China. This study aimed to estimate the incidence of GIST in urban population from mainland China in 2016. METHODS: Urban Employee Basic Medical Insurance (UEBMI) and Urban Residence Basic Medical Insurance (URBMI) in China were used. The denominator of incidence was the total person-years of insured individuals in 2016 in the database, covering approximately 0.43 billion individuals. The numerator was the number of incident GIST cases in 2016. RESULTS: The crude incidence in 2016 was 0.40 per 100,000 person-years (95% CI, 0.06-1.03). Male incidence was higher than female incidence (0.44 vs. 0.36, rate ratio: 1.22, p < 0.001). The mean age at diagnosis was 55.20 years (SD = 14.26) and the incidence among those aged 50 years or older was 2.63 times (0.84 vs. 0.32, p < 0.001) higher than those aged under 50. The highest incidence was observed in East China (2.29, 95% CI: 0.46-5.54). CONCLUSIONS: The incidence of GIST in mainland China was lower than Europe, North America and Korea. The mean age at diagnosis of GIST in China was younger than that of Europe and Canada. This study provides useful information to further research, policy formulating and management of GIST.
BACKGROUND: Information on incidence of gastrointestinal stromal tumor (GIST), the most common type of mesenchymal tumor in gastrointestinal tract, was limited in China. This study aimed to estimate the incidence of GIST in urban population from mainland China in 2016. METHODS: Urban Employee Basic Medical Insurance (UEBMI) and Urban Residence Basic Medical Insurance (URBMI) in China were used. The denominator of incidence was the total person-years of insured individuals in 2016 in the database, covering approximately 0.43 billion individuals. The numerator was the number of incident GIST cases in 2016. RESULTS: The crude incidence in 2016 was 0.40 per 100,000 person-years (95% CI, 0.06-1.03). Male incidence was higher than female incidence (0.44 vs. 0.36, rate ratio: 1.22, p < 0.001). The mean age at diagnosis was 55.20 years (SD = 14.26) and the incidence among those aged 50 years or older was 2.63 times (0.84 vs. 0.32, p < 0.001) higher than those aged under 50. The highest incidence was observed in East China (2.29, 95% CI: 0.46-5.54). CONCLUSIONS: The incidence of GIST in mainland China was lower than Europe, North America and Korea. The mean age at diagnosis of GIST in China was younger than that of Europe and Canada. This study provides useful information to further research, policy formulating and management of GIST.
Authors: Bengt Nilsson; Per Bümming; Jeanne M Meis-Kindblom; Anders Odén; Aydin Dortok; Bengt Gustavsson; Katarzyna Sablinska; Lars-Gunnar Kindblom Journal: Cancer Date: 2005-02-15 Impact factor: 6.860
Authors: Andrew Dunford; David M Weinstock; Virginia Savova; Steven E Schumacher; John P Cleary; Akinori Yoda; Timothy J Sullivan; Julian M Hess; Alexander A Gimelbrant; Rameen Beroukhim; Michael S Lawrence; Gad Getz; Andrew A Lane Journal: Nat Genet Date: 2016-11-21 Impact factor: 38.330