Literature DB >> 33318020

BKC-2, a New BKC Variant Detected in MCR-9.1-Producing Enterobacter hormaechei subsp. xiangfangensis.

Willames M B S Martins1,2, Evelin R Martins3, Letícia K de Andrade3, Refath Farzana2, Timothy R Walsh4, Mark A Toleman2, Mara C L Nogueira5, Ana C Gales1.   

Abstract

We characterized a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of the antimicrobial resistance genes. An Enterobacter spp. isolate (Ec61) was recovered in 2014 from a transtracheal aspirate sample from a patient admitted to a Brazilian tertiary hospital and submitted to further microbiological and genomic characterization. Ec61 was identified as Enterobacter hormaechei subsp. xiangfangensis strain ST451, showing an MDR profile and the presence of genes codifying the new β-lactamase variants BKC-2 and ACT-84 and the mobile colistin resistance gene mcr-9.1.
Copyright © 2021 American Society for Microbiology.

Entities:  

Keywords:  antimicrobial resistance; carbapenemase; phosphoethanolamine transferase; plasmids

Mesh:

Substances:

Year:  2021        PMID: 33318020      PMCID: PMC8092528          DOI: 10.1128/AAC.01193-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  17 in total

1.  Mobilization of blaBKC-1 by ISKpn23?

Authors:  Sally R Partridge
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

2.  Direct in Gel Genomic Detection of Antibiotic Resistance Genes in S1 Pulsed Field Electrophoresis Gels.

Authors:  Mark A Toleman
Journal:  Methods Mol Biol       Date:  2018

3.  Detection of BKC-1 in Citrobacter freundii: A clue to mobilisation in an IncQ1 plasmid carrying blaBKC-1.

Authors:  Willames M B S Martins; Bruna M S Seco; Jorge L M Sampaio; Kirsty Sands; Mark A Toleman; Ana C Gales
Journal:  Int J Antimicrob Agents       Date:  2020-05-29       Impact factor: 5.283

Review 4.  Carbapenemase-Producing Organisms: A Global Scourge.

Authors:  Robert A Bonomo; Eileen M Burd; John Conly; Brandi M Limbago; Laurent Poirel; Julie A Segre; Lars F Westblade
Journal:  Clin Infect Dis       Date:  2018-04-03       Impact factor: 9.079

5.  Characterization of BKC-1 class A carbapenemase from Klebsiella pneumoniae clinical isolates in Brazil.

Authors:  Adriana Giannini Nicoletti; Marcelo F M Marcondes; Willames M B S Martins; Luiz G P Almeida; Marisa F Nicolás; Ana T R Vasconcelos; Vitor Oliveira; Ana Cristina Gales
Journal:  Antimicrob Agents Chemother       Date:  2015-06-08       Impact factor: 5.191

6.  A link between the newly described colistin resistance gene mcr-9 and clinical Enterobacteriaceae isolates carrying blaSHV-12 from horses in Sweden.

Authors:  Stefan Börjesson; Christina Greko; Mattias Myrenås; Annica Landén; Oskar Nilsson; Karl Pedersen
Journal:  J Glob Antimicrob Resist       Date:  2019-09-05       Impact factor: 4.035

7.  Frequency of BKC-1-Producing Klebsiella Species Isolates.

Authors:  Willames M B S Martins; Adriana G Nicoletti; Silvia R Santos; Jorge L M Sampaio; Ana C Gales
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

8.  Drugs of last resort? The use of polymyxins and tigecycline at US Veterans Affairs medical centers, 2005-2010.

Authors:  Benedikt Huttner; Makoto Jones; Michael A Rubin; Melinda M Neuhauser; Adi Gundlapalli; Matthew Samore
Journal:  PLoS One       Date:  2012-05-16       Impact factor: 3.240

9.  Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads.

Authors:  Ryan R Wick; Louise M Judd; Claire L Gorrie; Kathryn E Holt
Journal:  PLoS Comput Biol       Date:  2017-06-08       Impact factor: 4.475

10.  Identification of Novel Mobilized Colistin Resistance Gene mcr-9 in a Multidrug-Resistant, Colistin-Susceptible Salmonella enterica Serotype Typhimurium Isolate.

Authors:  Laura M Carroll; Ahmed Gaballa; Claudia Guldimann; Genevieve Sullivan; Lory O Henderson; Martin Wiedmann
Journal:  mBio       Date:  2019-05-07       Impact factor: 7.867

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