Seema Pursnani1, Maqdooda Merchant2. 1. The Permanente Medical Group, Kaiser Permanente, Santa Clara, CA, USA. Electronic address: seema.k.pursnani@kp.org. 2. Kaiser Permanente Division of Research, Oakland, California, USA.
Abstract
BACKGROUND AND AIMS: South Asian ethnicity has been associated with increased cardiovascular risk, in the context of a greater burden of traditional cardiovascular disease risk factors. We aimed to identify the 10-year incidence of coronary heart disease (CHD) in South Asians, as compared to other racial-ethnic groups, in a retrospective cohort study, using the Kaiser Permanente Northern California integrated health care system, and to understand whether traditional risk factors could explain differences in outcomes. METHODS AND RESULTS: A study cohort established in 2006, with 10-year follow-up, identified a total n = 341,309 patients, including 5149 South Asians, aged 30-70 years who underwent a screening lipid panel and had no prior history of CHD. There were a total of 460 (8.93%) patients with at least one cardiovascular event, including cardiovascular death, coronary artery revascularization, and myocardial infarction, in South Asians, as compared to 5.66% patients in the total population (p < 0.0001). In a multivariable logistic regression analysis, South Asian ethnicity, compared to White race, was associated with an adjusted odds ratio (aOR) = 2.04 (95%CI: 1.83, 2.28) in predicting the cardiovascular outcomes. CONCLUSIONS: South Asian ethnicity, even after adjustment for traditional risk factors, is associated with an increased risk of coronary heart disease outcomes. This risk was greater than other studied racial-ethnic groups and second only to diabetes in CHD risk prediction.
BACKGROUND AND AIMS: South Asian ethnicity has been associated with increased cardiovascular risk, in the context of a greater burden of traditional cardiovascular disease risk factors. We aimed to identify the 10-year incidence of coronary heart disease (CHD) in South Asians, as compared to other racial-ethnic groups, in a retrospective cohort study, using the Kaiser Permanente Northern California integrated health care system, and to understand whether traditional risk factors could explain differences in outcomes. METHODS AND RESULTS: A study cohort established in 2006, with 10-year follow-up, identified a total n = 341,309 patients, including 5149 South Asians, aged 30-70 years who underwent a screening lipid panel and had no prior history of CHD. There were a total of 460 (8.93%) patients with at least one cardiovascular event, including cardiovascular death, coronary artery revascularization, and myocardial infarction, in South Asians, as compared to 5.66% patients in the total population (p < 0.0001). In a multivariable logistic regression analysis, South Asian ethnicity, compared to White race, was associated with an adjusted odds ratio (aOR) = 2.04 (95%CI: 1.83, 2.28) in predicting the cardiovascular outcomes. CONCLUSIONS: South Asian ethnicity, even after adjustment for traditional risk factors, is associated with an increased risk of coronary heart disease outcomes. This risk was greater than other studied racial-ethnic groups and second only to diabetes in CHD risk prediction.
Authors: Mahmoud Al Rifai; Alka M Kanaya; Namratha R Kandula; Jaideep Patel; Mouaz H Al-Mallah; Matthew Budoff; Miguel Cainzos-Achirica; Michael H Criqui; Salim S Virani Journal: Curr Probl Cardiol Date: 2022-01-07 Impact factor: 16.464
Authors: Alka M Kanaya; Ann W Hsing; Sela V Panapasa; Namratha R Kandula; Maria Rosario G Araneta; Daichi Shimbo; Paul Wang; Scarlett L Gomez; Jinkook Lee; K M Venkat Narayan; Marjorie K L Mala Mau; Sonali Bose; Martha L Daviglus; Frank B Hu; Nadia Islam; Chandra L Jackson; Merle Kataoka-Yahiro; John S K Kauwe; Simin Liu; Grace X Ma; Tung Nguyen; Latha Palaniappan; V Wendy Setiawan; Chau Trinh-Shevrin; Janice Y Tsoh; Dhananjay Vaidya; Barbara Vickrey; Thomas J Wang; Nathan D Wong; Sean Coady; Yuling Hong Journal: Ann Intern Med Date: 2022-01-04 Impact factor: 51.598
Authors: Mahmoud Al Rifai; Alka M Kanaya; Namratha R Kandula; Miguel Cainzos-Achirica; Jaideep Patel; Matthew Budoff; Michael H Criqui; Michael J Blaha; Salim S Virani Journal: Atherosclerosis Date: 2020-12-07 Impact factor: 5.162