| Literature DB >> 33317516 |
Masatoki Yoshida1, Kazufumi Nakamura2, Toru Miyoshi1, Masashi Yoshida1, Megumi Kondo1, Kaoru Akazawa1, Tomonari Kimura1, Hiroaki Ohtsuka1, Yuko Ohno1,3, Daiji Miura4, Hiroshi Ito1.
Abstract
Entities:
Year: 2020 PMID: 33317516 PMCID: PMC7737252 DOI: 10.1186/s12933-020-01181-7
Source DB: PubMed Journal: Cardiovasc Diabetol ISSN: 1475-2840 Impact factor: 9.951
Fig. 4Effects of pitavastatin, pemafibrate or combination of pitavastatin and pemafibrate on endothelium-dependent vascular relaxations in response to acetylcholine. Rats were fed a normal diet (ND) or a high-salt and high-fat diet (HD). The rats were divided into five groups and treated with a vehicle, pitavastatin, pemafibrate (K-877), or combination of pitavastatin and pemafibrate. Data are expressed as the mean ± SD. *P < 0.001, HD-vehicle group versus ND-vehicle group. #P < 0.05, HD-combination group versus HD-vehicle group. Number of rats in each group: ND-vehicle, n = 4; HD-vehicle, n = 5; HD-pitavastatin, n = 5; HD-pemafibrate, n = 5; and HD-combination, n = 5. Statistical analysis was performed using mixed effect model with a Bonferroni post-hoc test