Anna Lindblad1, Simone Kaucher1, Philipp Jaehn2, Hiltraud Kajüter3, Bernd Holleczek4, Lauren Lissner5, Heiko Becher6, Volker Winkler1. 1. Heidelberg Institute of Global Health, University Hospital Heidelberg, 69120 Heidelberg, Germany. 2. Institute of Social Medicine and Epidemiology, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany. 3. Cancer Registry, North Rhine-Westphalia, 44801 Bochum, Germany. 4. Saarland Cancer Registry, 66119 Saarbrücken, Germany. 5. School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, 41346 Gothenburg, Sweden. 6. Institute for Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Abstract
OBJECTIVE: Previous studies have shown that the incidence of gastric cancer (GC), and particularly intestinal GC, is higher among resettlers from the former Soviet Union (FSU) than in the general German population. Our aim was to investigate if the higher risk remains over time. METHODS: GC cases between 1994 and 2013, in a cohort of 32,972 resettlers, were identified by the respective federal cancer registry. Age-standardized rates (ASRs) and standardized incidence ratios (SIRs) were analyzed in comparison to the general population for GC subtypes according to the Laurén classification. Additionally, the cohort was pooled with data from a second resettler cohort from Saarland to investigate time trends using negative binomial regression. RESULTS: The incidence of intestinal GC was elevated among resettlers in comparison to the general population (SIR (men) 1.64, 95% CI: 1.09-2.37; SIR (women) 1.91, 95% CI: 1.15-2.98). The analysis with the pooled data confirmed an elevated SIR, which was stable over time. CONCLUSION: Resettlers' higher risk of developing intestinal GC does not attenuate towards the incidence in the general German population. Dietary and lifestyle patterns might amplify the risk of GC, and we believe that further investigation of risk behaviors is needed to better understand the development of disease pattern among migrants.
OBJECTIVE: Previous studies have shown that the incidence of gastric cancer (GC), and particularly intestinal GC, is higher among resettlers from the former Soviet Union (FSU) than in the general German population. Our aim was to investigate if the higher risk remains over time. METHODS: GC cases between 1994 and 2013, in a cohort of 32,972 resettlers, were identified by the respective federal cancer registry. Age-standardized rates (ASRs) and standardized incidence ratios (SIRs) were analyzed in comparison to the general population for GC subtypes according to the Laurén classification. Additionally, the cohort was pooled with data from a second resettler cohort from Saarland to investigate time trends using negative binomial regression. RESULTS: The incidence of intestinal GC was elevated among resettlers in comparison to the general population (SIR (men) 1.64, 95% CI: 1.09-2.37; SIR (women) 1.91, 95% CI: 1.15-2.98). The analysis with the pooled data confirmed an elevated SIR, which was stable over time. CONCLUSION: Resettlers' higher risk of developing intestinal GC does not attenuate towards the incidence in the general German population. Dietary and lifestyle patterns might amplify the risk of GC, and we believe that further investigation of risk behaviors is needed to better understand the development of disease pattern among migrants.
Entities:
Keywords:
Germany; Laurén classification; cohort; former Soviet Union; incidence; migrants; stomach cancer
Authors: Carlos A González; Paula Jakszyn; Guillem Pera; Antonio Agudo; Sheila Bingham; Domenico Palli; Pietro Ferrari; Heiner Boeing; Giuseppe del Giudice; Mario Plebani; Fátima Carneiro; Gabriella Nesi; Franco Berrino; Carlotta Sacerdote; Rosario Tumino; Salvatore Panico; Göran Berglund; Henrik Simán; Olof Nyrén; Göran Hallmans; Carmen Martinez; Miren Dorronsoro; Aurelio Barricarte; Carmen Navarro; José R Quirós; Naomi Allen; Timothy J Key; Nicholas E Day; Jakob Linseisen; Gabriele Nagel; Manuela M Bergmann; Kim Overvad; Majken K Jensen; Anne Tjonneland; Anja Olsen; H Bas Bueno-de-Mesquita; Marga Ocke; Petra H M Peeters; Mattijs E Numans; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Antonia Trichopoulou; Theodora Psaltopoulou; Dimitrios Roukos; Eiliv Lund; Bertrand Hemon; Rudolf Kaaks; Teresa Norat; Elio Riboli Journal: J Natl Cancer Inst Date: 2006-03-01 Impact factor: 13.506
Authors: Ahmedin Jemal; Freddie Bray; Melissa M Center; Jacques Ferlay; Elizabeth Ward; David Forman Journal: CA Cancer J Clin Date: 2011-02-04 Impact factor: 508.702