Tailai An1, Qian Liang2, Tengfei Hao1,3, Lingna Deng2, Xiaofang Lu4, Yan Wang5, Lyujia Cheng1, Wang Wu1,3, Changhua Zhang1. 1. Center of Digestive Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. 2. Center of Scientific Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. 3. Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 4. Department of Pathology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. 5. Department of Radiology, People's Hospital of Shenzhen, Shenzhen, China.
Abstract
INTRODUCTION: Tartrate-resistant acid phosphatase (ACP5) plays crucial roles in multiple pathological processes, including the genesis and progression of malignant tumors. We performed this study with the purpose of determining whether ACP5 is a crucial biomarker significantly related to prognoses of gastric cancer (GC) patients. METHODS: The expression level of ACP5 level was assessed among 170 GC specimens using immunohistochemistry. The associations between ACP5 expression and clinicopathological variables were evaluated. Univariate and multivariate Cox regression analyses were performed to confirm independent prognostic factors for GC patients. RESULTS: It was revealed that ACP5 expression level in GC tissue was significantly associated with depth of invasion (p = 0.029) and TNM stage (p = 0.036). ACP5 was demonstrated by multivariate Cox regression analysis to be an independent prognostic factor for overall survival (OS) (p = 0.001) and recurrence-free survival (RFS) (p = 0.011) of GC patients. CONCLUSIONS: The expression of ACP5 in GC tissue was significantly higher than that in normal tissues, and its overexpression was associated with a poorer prognosis, suggesting its potential roles in preventing and treating GC.
INTRODUCTION: Tartrate-resistant acid phosphatase (ACP5) plays crucial roles in multiple pathological processes, including the genesis and progression of malignant tumors. We performed this study with the purpose of determining whether ACP5 is a crucial biomarker significantly related to prognoses of gastric cancer (GC) patients. METHODS: The expression level of ACP5 level was assessed among 170 GC specimens using immunohistochemistry. The associations between ACP5 expression and clinicopathological variables were evaluated. Univariate and multivariate Cox regression analyses were performed to confirm independent prognostic factors for GC patients. RESULTS: It was revealed that ACP5 expression level in GC tissue was significantly associated with depth of invasion (p = 0.029) and TNM stage (p = 0.036). ACP5 was demonstrated by multivariate Cox regression analysis to be an independent prognostic factor for overall survival (OS) (p = 0.001) and recurrence-free survival (RFS) (p = 0.011) of GC patients. CONCLUSIONS: The expression of ACP5 in GC tissue was significantly higher than that in normal tissues, and its overexpression was associated with a poorer prognosis, suggesting its potential roles in preventing and treating GC.
Authors: Kenneth L Scott; Cristina Nogueira; Timothy P Heffernan; Remco van Doorn; Sabin Dhakal; Jason A Hanna; Chengyin Min; Mariela Jaskelioff; Yonghong Xiao; Chang-Jiun Wu; Lisa A Cameron; Samuel R Perry; Rhamy Zeid; Tamar Feinberg; Minjung Kim; George Vande Woude; Scott R Granter; Marcus Bosenberg; Gerald C Chu; Ronald A DePinho; David L Rimm; Lynda Chin Journal: Cancer Cell Date: 2011-07-12 Impact factor: 31.743
Authors: L Xia; W Huang; D Tian; Z Chen; L Zhang; Y Li; H Hu; J Liu; Z Chen; G Tang; J Dou; S Sha; B Xu; C Liu; J Ma; S Zhang; M Li; D Fan; Y Nie; K Wu Journal: Oncogene Date: 2013-04-22 Impact factor: 9.867
Authors: C T Karadedou; A R Gomes; J Chen; M Petkovic; K-K Ho; A K Zwolinska; A Feltes; S Y Wong; K Y K Chan; Y-N Cheung; J W H Tsang; J J Brosens; U-S Khoo; E W-F Lam Journal: Oncogene Date: 2011-08-22 Impact factor: 9.867