Katherine Ogurtsova1, Stephan Morbach2, Burkhard Haastert3, Michal Dubský4, Gerhard Rümenapf5, Dan Ziegler6, Alexandra Jirkovska4, Andrea Icks7. 1. Institute for Health Services Research and Health Economics, German Diabetes Center, Düsseldorf, Germany; German Centre for Diabetes Research (DZD), Neuherberg, Germany. Electronic address: katherine.ogurtsova@ddz.de. 2. Department of Diabetes and Angiology, Marienkrankenhaus, Soest, Germany; Institute for Health Services Research and Health Economics, Faculty of Medicine, Heinrich-Heine- University, Düsseldorf, Germany. 3. Institute for Health Services Research and Health Economics, Faculty of Medicine, Heinrich-Heine- University, Düsseldorf, Germany; mediStatistica, Neuenrade, Germany. 4. Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. 5. Department of Vascular Surgery, Centre of Vascular Medicine Oberrhein, Diakonissen-Stiftungs-Krankenhaus, Speyer, Germany. 6. Institute for Clinical Diabetology, German Diabetes Center and Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. 7. Institute for Health Services Research and Health Economics, German Diabetes Center, Düsseldorf, Germany; German Centre for Diabetes Research (DZD), Neuherberg, Germany; Institute for Health Services Research and Health Economics, Faculty of Medicine, Heinrich-Heine- University, Düsseldorf, Germany.
Abstract
AIMS: Our aim was to comprehensively estimate the incidence of diabetic foot ulcer (DFU) recurrence and corresponding risk factors in two cohorts. METHODS: Prospective data from patients with active DFU from two diabetes centres in Germany (GER, n = 222) and the Czech Republic (CZ, n = 99) were analysed. Crude cumulative incidences were obtained. Additionally, time to recurrence and risk factors were investigated using multivariate Cox models. RESULTS: 69%(154) of patients in GER and 70%(69) in CZ experienced at least one DFU recurrence; 25%(56) in DEU and 15%(15) in CZ died; 5%(11) and 9%(9) were lost to follow-up. The crude cumulative incidence in the first year was 28% in GER and 25% in CZ; 68%/70% within ten years, and 69%/70% in 15 years. In GER, renal replacement therapy was associated with shorter time to recurrence (HR = 3.71, 95%CI:1.26-10.87); no history of DFU before the index lesion with longer time to recurrence (HR = 0.62, 0.42-0.92). In CZ, type 2 diabetes (HR = 2.57, 1.18-5.62) and index ulcer treatment by minor amputation (HR = 2.11, 1.03-4.33) were associated with shorter time to recurrence. CONCLUSIONS: Cumulative DFU recurrence was approximately 70% in 15 years in both cohorts. We found a significantly higher risk of future recurrence in patients having a consecutive ulcer compared with the first ever ulcer.
AIMS: Our aim was to comprehensively estimate the incidence of diabetic foot ulcer (DFU) recurrence and corresponding risk factors in two cohorts. METHODS: Prospective data from patients with active DFU from two diabetes centres in Germany (GER, n = 222) and the Czech Republic (CZ, n = 99) were analysed. Crude cumulative incidences were obtained. Additionally, time to recurrence and risk factors were investigated using multivariate Cox models. RESULTS: 69%(154) of patients in GER and 70%(69) in CZ experienced at least one DFU recurrence; 25%(56) in DEU and 15%(15) in CZ died; 5%(11) and 9%(9) were lost to follow-up. The crude cumulative incidence in the first year was 28% in GER and 25% in CZ; 68%/70% within ten years, and 69%/70% in 15 years. In GER, renal replacement therapy was associated with shorter time to recurrence (HR = 3.71, 95%CI:1.26-10.87); no history of DFU before the index lesion with longer time to recurrence (HR = 0.62, 0.42-0.92). In CZ, type 2 diabetes (HR = 2.57, 1.18-5.62) and index ulcer treatment by minor amputation (HR = 2.11, 1.03-4.33) were associated with shorter time to recurrence. CONCLUSIONS: Cumulative DFU recurrence was approximately 70% in 15 years in both cohorts. We found a significantly higher risk of future recurrence in patients having a consecutive ulcer compared with the first ever ulcer.