Literature DB >> 33315896

Cost of a new method of active screening for human African trypanosomiasis in the Democratic Republic of the Congo.

Rian Snijders1, Alain Fukinsia2, Yves Claeys1, Alain Mpanya2, Epco Hasker1, Filip Meheus3, Erick Miaka2, Marleen Boelaert1.   

Abstract

BACKGROUND: Human African trypanosomiases caused by the Trypanosoma brucei gambiense parasite is a lethal disease targeted for eradication. One of the main disease control strategies is active case-finding through outreach campaigns. In 2014, a new method for active screening was developed with mini, motorcycle-based, teams. This study compares the cost of two active case-finding approaches, namely the traditional mobile teams and mini mobile teams, in the two health districts of the Democratic Republic of the Congo.
METHODS: The financial and economic costs of both approaches were estimated from a health care provider perspective. Cost and operational data were collected for 12 months for 1 traditional team and 3 mini teams. The cost per person screened and diagnosed was calculated and univariate sensitivity analysis was conducted to identify the main cost drivers.
RESULTS: During the study period in total 264,630 people were screened, and 23 HAT cases detected. The cost per person screened was lower for a mini team than for a traditional team in the study setting (US$1.86 versus US$2.08). A comparable result was found in a scenario analysis, assuming both teams would operate in a similar setting, with the cost per person screened by a mini team 15% lower than the cost per person screened by a traditional team (1.86 $ vs 2.14$). The main explanations for this lower cost are that mini teams work with fewer human resources, cheaper means of transportation and do not perform the Capillary Tube Centrifugation test or card agglutination test dilutions. DISCUSSION: Active HAT screening with mini mobile teams has a lower cost and could be a cost-effective alternative for active case-finding. Further research is needed to determine if mini mobile teams have similar or better yields than traditional mobile teams in terms of detections and cases successfully treated.

Entities:  

Year:  2020        PMID: 33315896      PMCID: PMC7769601          DOI: 10.1371/journal.pntd.0008832

Source DB:  PubMed          Journal:  PLoS Negl Trop Dis        ISSN: 1935-2727


  16 in total

1.  Discounting health outcomes in economic evaluation: the ongoing debate.

Authors:  Johan L Severens; Richard J Milne
Journal:  Value Health       Date:  2004 Jul-Aug       Impact factor: 5.725

2.  Evaluation of the micro-CATT, CATT/Trypanosoma brucei gambiense, and LATEX/T b gambiense methods for serodiagnosis and surveillance of human African trypanosomiasis in West and Central Africa.

Authors:  Philippe Truc; Veerle Lejon; Eddy Magnus; Vincent Jamonneau; Auguste Nangouma; Didier Verloo; Laurent Penchenier; Philippe Büscher
Journal:  Bull World Health Organ       Date:  2002       Impact factor: 9.408

3.  Control and surveillance of human African trypanosomiasis.

Authors: 
Journal:  World Health Organ Tech Rep Ser       Date:  2013

4.  Sensitivity and specificity of HAT Sero-K-SeT, a rapid diagnostic test for serodiagnosis of sleeping sickness caused by Trypanosoma brucei gambiense: a case-control study.

Authors:  Philippe Büscher; Pascal Mertens; Thierry Leclipteux; Quentin Gilleman; Diane Jacquet; Dieudonné Mumba-Ngoyi; Patient Pati Pyana; Marleen Boelaert; Veerle Lejon
Journal:  Lancet Glob Health       Date:  2014-05-09       Impact factor: 26.763

5.  Accuracy of individual rapid tests for serodiagnosis of gambiense sleeping sickness in West Africa.

Authors:  Vincent Jamonneau; Oumou Camara; Hamidou Ilboudo; Moana Peylhard; Mathurin Koffi; Hassane Sakande; Louis N'Dri; Djénéba Sanou; Emilie Dama; Mamadou Camara; Veerle Lejon
Journal:  PLoS Negl Trop Dis       Date:  2015-02-02

Review 6.  The natural progression of Gambiense sleeping sickness: what is the evidence?

Authors:  Francesco Checchi; João A N Filipe; Michael P Barrett; Daniel Chandramohan
Journal:  PLoS Negl Trop Dis       Date:  2008-12-23

7.  Cost-effectiveness of algorithms for confirmation test of human African trypanosomiasis.

Authors:  Pascal Lutumba; Filip Meheus; Jo Robays; Constantin Miaka; Victor Kande; Philippe Büscher; Bruno Dujardin; Marleen Boelaert
Journal:  Emerg Infect Dis       Date:  2007-10       Impact factor: 6.883

Review 8.  Eliminating human African trypanosomiasis: where do we stand and what comes next?

Authors:  Pere P Simarro; Jean Jannin; Pierre Cattand
Journal:  PLoS Med       Date:  2008-02       Impact factor: 11.069

Review 9.  Epidemiology of human African trypanosomiasis.

Authors:  Jose R Franco; Pere P Simarro; Abdoulaye Diarra; Jean G Jannin
Journal:  Clin Epidemiol       Date:  2014-08-06       Impact factor: 4.790

Review 10.  The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History.

Authors:  Harry P De Koning
Journal:  Trop Med Infect Dis       Date:  2020-01-19
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  4 in total

1.  Cost-effectiveness modelling to optimise active screening strategy for gambiense human African trypanosomiasis in endemic areas of the Democratic Republic of Congo.

Authors:  Christopher N Davis; Kat S Rock; Marina Antillón; Erick Mwamba Miaka; Matt J Keeling
Journal:  BMC Med       Date:  2021-04-01       Impact factor: 8.775

2.  Cost-effectiveness of sleeping sickness elimination campaigns in five settings of the Democratic Republic of Congo.

Authors:  Kat S Rock; Fabrizio Tediosi; Marina Antillon; Ching-I Huang; Ronald E Crump; Paul E Brown; Rian Snijders; Erick Mwamba Miaka; Matt J Keeling
Journal:  Nat Commun       Date:  2022-02-25       Impact factor: 14.919

3.  Monitoring the elimination of gambiense human African trypanosomiasis in the historical focus of Batié, South-West Burkina Faso.

Authors:  Charlie Franck Alfred Compaoré; Jacques Kaboré; Hamidou Ilboudo; Lian Francesca Thomas; Laura Cristina Falzon; Mohamed Bamba; Hassane Sakande; Minayégninrin Koné; Dramane Kaba; Clarisse Bougouma; Ilboudo Adama; Ouedraogo Amathe; Adrien Marie Gaston Belem; Eric Maurice Fèvre; Philippe Büscher; Veerle Lejon; Vincent Jamonneau
Journal:  Parasite       Date:  2022-05-11       Impact factor: 3.020

4.  Costs and Outcomes of Integrated Human African Trypanosomiasis Surveillance System Using Rapid Diagnostic Tests, Democratic Republic of the Congo.

Authors:  Rian Snijders; Alain Fukinsia; Yves Claeys; Epco Hasker; Alain Mpanya; Erick Miaka; Filip Meheus; Marleen Boelaert
Journal:  Emerg Infect Dis       Date:  2021-08       Impact factor: 6.883

  4 in total

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