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Literature DB >> 33315498

Thioridazine hydrochloride: an antipsychotic agent that inhibits tumor growth and lung metastasis in triple-negative breast cancer via inducing G0/G1 arrest and apoptosis.

Yanlin Song^1,2, Lu Li¹, Jiao Chen¹, Hongli Chen¹, Bomiao Cui¹, Yun Feng¹, Ping Zhang¹, Qiangsheng Zhang¹, Yong Xia^3,4, Min Luo¹.

Abstract

ABBREVIATIONS: CCK8: Cell Counting Kit-8; CDK: cyclin-dependent kinase; DRD2: dopamine D2 receptor; ERK1/2: extracellular signal-regulated kinase 1/2; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; H&E: hematoxylin and eosin; MMP: membrane potential; NAC: N-acetyl-L-cysteine; PI: Propidium iodide; Rh123: rhodamine-123; ROS: reactive oxygen species; TBST: tris-buffered saline containing 0.1% Tween 20 TNBC: Triple-negative breast cancer; Thi-hyd: Thioridazine hydrochloride.

Entities: Chemical

Keywords: PI3K/AKT pathway; Thioridazine hydrochloride; antipsychotic agent; triple-negative breast cancer

Mesh：

Substances：

Year: 2020 PMID： 33315498 PMCID： PMC7781661 DOI： 10.1080/15384101.2020.1850969

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

38 in total

Review 1. ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence.

Authors: Sebastien Cagnol; Jean-Claude Chambard
Journal: FEBS J Date: 2009-10-16 Impact factor: 5.542

2. Dual inhibition of Akt and ERK signaling induces cell senescence in triple-negative breast cancer.

Authors: Qiang He; Shuyin Xue; Yiqing Tan; Ling Zhang; Qing Shao; Lei Xing; Yunhai Li; Tingxiu Xiang; Xinrong Luo; Guosheng Ren
Journal: Cancer Lett Date: 2019-02-08 Impact factor: 8.679

3. FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cells.

Authors: Jichao He; Steven Wink; Hans de Bont; Sylvia Le Dévédec; Yinghui Zhang; Bob van de Water
Journal: Biochem Pharmacol Date: 2019-09-16 Impact factor: 5.858

4. Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G₁ arrest independent of DRD2.

Authors: Matthew Tegowski; Cheng Fan; Albert S Baldwin
Journal: J Biol Chem Date: 2018-08-21 Impact factor: 5.157

5. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer.

Authors: Jiasheng Mu; Haineng Xu; Yu Yang; Weidan Huang; Jing Xiao; Maolan Li; Zhujun Tan; Qichen Ding; Lin Zhang; Jianhua Lu; Xiangsong Wu; Yingbin Liu
Journal: Oncol Rep Date: 2014-03-06 Impact factor: 3.906

6. Mitochondria-Mediated Pathway Regulates C2C12 Cell Apoptosis Induced by Fluoride.

Authors: Pan-Pan Tan; Bian-Hua Zhou; Wen-Peng Zhao; Liu-Shu Jia; Jing Liu; Hong-Wei Wang
Journal: Biol Trace Elem Res Date: 2018-03-29 Impact factor: 3.738

7. Thioridazine inhibits angiogenesis and tumor growth by targeting the VEGFR-2/PI3K/mTOR pathway in ovarian cancer xenografts.

Authors: Mi Sun Park; Seung Myung Dong; Boh-Ram Kim; Seung Hee Seo; Sokbom Kang; Eun-Ju Lee; Seung-Hoon Lee; Seung Bae Rho
Journal: Oncotarget Date: 2014-07-15

8. AXL knockdown gene signature reveals a drug repurposing opportunity for a class of antipsychotics to reduce growth and metastasis of triple-negative breast cancer.

Authors: Marie-Anne Goyette; Rebecca Cusseddu; Islam Elkholi; Afnan Abu-Thuraia; Nehme El-Hachem; Benjamin Haibe-Kains; Jean-Philippe Gratton; Jean-François Côté
Journal: Oncotarget Date: 2019-03-12