Isolde A R Kuijlaars1, Madelon van Emst1, Janjaap van der Net2, Merel A Timmer1, Kathelijn Fischer1. 1. Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. 2. Center for Child Development, Exercise and Physical Literacy, Children's Hospital of the University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Abstract
INTRODUCTION: The Haemophilia Activities List (HAL) is a preferred instrument to measure self-reported limitations in activities in persons with haemophilia (PWH). Information on reliability and interpretability of HAL scores is lacking. AIM: To examine the test-retest reliability and smallest detectable change (SDC) of the HAL in adult PWH. METHODS: Fifty adult (≥18 years) persons with mild to severe haemophilia completed the HAL (42 items, 7 domains, optimum 100) at baseline (T0) and 3-4 weeks later (T1). The intraclass correlation coefficient (ICC) and SDC were calculated for sum and component scores. RESULTS: Fifty persons with haemophilia were included (median age 49 years; 92% haemophilia A; 70% severe haemophilia). The median (interquartile ranges) HAL sum score was 77 (62 to 99) at T0 and 81 (64 to 98) at T1. Reliability was good with ICCs for sum and component scores >0.9. The SDC for the sum score was 10.2, for the upper extremity component score 9.2, for the basic lower extremity component score 16.7 and for the complex lower extremity component score 13.4. CONCLUSION: The HAL has a good reliability for the sum and component scores. Score changes of the normalized sum HAL score greater than the SDC 10.2 indicate that the change was not a result of measurement error.
INTRODUCTION: The Haemophilia Activities List (HAL) is a preferred instrument to measure self-reported limitations in activities in persons with haemophilia (PWH). Information on reliability and interpretability of HAL scores is lacking. AIM: To examine the test-retest reliability and smallest detectable change (SDC) of the HAL in adult PWH. METHODS: Fifty adult (≥18 years) persons with mild to severe haemophilia completed the HAL (42 items, 7 domains, optimum 100) at baseline (T0) and 3-4 weeks later (T1). The intraclass correlation coefficient (ICC) and SDC were calculated for sum and component scores. RESULTS: Fifty persons with haemophilia were included (median age 49 years; 92% haemophilia A; 70% severe haemophilia). The median (interquartile ranges) HAL sum score was 77 (62 to 99) at T0 and 81 (64 to 98) at T1. Reliability was good with ICCs for sum and component scores >0.9. The SDC for the sum score was 10.2, for the upper extremity component score 9.2, for the basic lower extremity component score 16.7 and for the complex lower extremity component score 13.4. CONCLUSION: The HAL has a good reliability for the sum and component scores. Score changes of the normalized sum HAL score greater than the SDC 10.2 indicate that the change was not a result of measurement error.
Authors: Isolde A R Kuijlaars; Lorynn Teela; Lize F D van Vulpen; Merel A Timmer; Michiel Coppens; Samantha C Gouw; Marjolein Peters; Marieke J H A Kruip; Marjon H Cnossen; Jelmer J Muis; Evelien S van Hoorn; Lotte Haverman; Kathelijn Fischer Journal: Res Pract Thromb Haemost Date: 2021-11-21
Authors: Isolde A R Kuijlaars; Janjaap van der Net; Tyler W Buckner; Christine L Kempton; Roger E G Schutgens; Kathelijn Fischer Journal: Haemophilia Date: 2021-09-08 Impact factor: 4.263
Authors: Ana Chimeno-Hernández; Felipe Querol-Giner; Sofía Pérez-Alenda; Rodrigo Núñez-Cortés; Carlos Cruz-Montecinos; Juan J Carrasco; Marta Aguilar-Rodríguez Journal: Haemophilia Date: 2022-04-01 Impact factor: 4.263
Authors: Marcel A L Hendriks; Johanna W M van Wanroij; Britta A P Laros-van Gorkom; Maria W G Nijhuis-van der Sanden; Thomas J Hoogeboom Journal: Haemophilia Date: 2021-05-04 Impact factor: 4.287