H Ilkhanipoor1, M Ahangar Davoodi2, S M Dehghani3, H Karamifar1, S M Abdollahzadeh4. 1. Department of Pediatric Endocrinology, Shiraz University of Medical Sciences, Shiraz, Iran. 2. Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran. 3. Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Department of Clinical Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract
BACKGROUND: Particular requirements of pediatric and adolescent liver-transplant (LT) recipients necessitate the evaluation of such population from the endocrine viewpoint. OBJECTIVE: To determine the endocrine disorders among LT recipients. METHODS: 129 LT recipients younger than 18 years, and at least 6 months post-LT with no pervious history of endocrine disorders were included in the study. Demographic, anthropometric and biochemical data were collected. RESULTS: 36% of cases had evidence of impaired fasting glucose; the problem, however, was dramatically resolved (decreased to 2.3%) by using of prediabetic diet. Identifying only 1 case of primary hypothyroidism indicated that thyroid dysfunction seems not to be a prevalent finding in the patients. 3 cases of rickets and no case of parathyroid dysfunction were identified. 11% of the study population were hypocalcemic (2 had rickets as well). Pubertal condition in 3 patients and delayed puberty before LT in 6 remained the same; further evaluation revealed they had hypogonadotropic hypogonadism. CONCLUSION: Regular monitoring for development of diabetes and hypocalcemia is indicated. Evaluation of those with delayed puberty for receiving sexual hormones is also recommended.
BACKGROUND: Particular requirements of pediatric and adolescent liver-transplant (LT) recipients necessitate the evaluation of such population from the endocrine viewpoint. OBJECTIVE: To determine the endocrine disorders among LT recipients. METHODS: 129 LT recipients younger than 18 years, and at least 6 months post-LT with no pervious history of endocrine disorders were included in the study. Demographic, anthropometric and biochemical data were collected. RESULTS: 36% of cases had evidence of impaired fasting glucose; the problem, however, was dramatically resolved (decreased to 2.3%) by using of prediabetic diet. Identifying only 1 case of primary hypothyroidism indicated that thyroid dysfunction seems not to be a prevalent finding in the patients. 3 cases of rickets and no case of parathyroid dysfunction were identified. 11% of the study population were hypocalcemic (2 had rickets as well). Pubertal condition in 3 patients and delayed puberty before LT in 6 remained the same; further evaluation revealed they had hypogonadotropic hypogonadism. CONCLUSION: Regular monitoring for development of diabetes and hypocalcemia is indicated. Evaluation of those with delayed puberty for receiving sexual hormones is also recommended.
Authors: R Shapiro; V Scantlebury; M L Jordan; C Vivas; D Ellis; S Lombardozzi-Lane; J J Fung; R L Simmons; T E Starzl Journal: Transplantation Date: 1999-03-15 Impact factor: 4.939
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