Gurudatta Moharir1, Akram A Naikawadi1, Jyoti Patil1, Prabhulingayya Bhixavatimath2, Ambadasu Bharatha3. 1. Department of Pharmacology, BLDE (Deemed to be University), Shri BM Patil Medical College, Vijayapur, Karnataka, India. 2. Department of Pharmacology, SNMC Medical College, Bagalkot, Karnataka, India. 3. Faculty of Medical Sciences, The University of the West Indies, Cave Hill Campus, Barbados, WI.
Abstract
Background: Type 2 diabetes mellitus (T2DM) is an increasingly common disorder characterized by chronic hyperglycemia and marked dyslipidemia. This study evaluates the effect of vitamin D supplementation alone and in combination with glimepiride in streptozotocin-induced T2DM in rats. Materials and methods: A total of 30 Wistar albino rats of either sex weighing 150-200 g were included in the study. The effect of oral administration of vitamin D was evaluated in streptozotocin-induced T2DM in rats. Blood glucose, serum insulin, serum HbA1c, and serum vitamin D were evaluated. Results: D treatment has significantly improved hyperglycemia, hyperinsulinemia, and insulin sensitivity compared with the non-treated diabetic rats. Oral administration of vitamin D in streptozotocin-induced T2DM reduced blood sugar levels, increased insulin levels (more prominently when administered along with glimepiride) and decreased HbA1c levels (p<0.005). Conclusions: Administration of vitamin D can improve hyperglycemia and hyperinsulinemia in streptozotocin-induced T2DM in rats. Thus, it could be considered as an add on therapy along with other antidiabetic drugs.
Background: Type 2 diabetes mellitus (T2DM) is an increasingly common disorder characterized by chronic hyperglycemia and marked dyslipidemia. This study evaluates the effect of vitamin D supplementation alone and in combination with glimepiride in streptozotocin-induced T2DM in rats. Materials and methods: A total of 30 Wistar albino rats of either sex weighing 150-200 g were included in the study. The effect of oral administration of vitamin D was evaluated in streptozotocin-induced T2DM in rats. Blood glucose, serum insulin, serum HbA1c, and serum vitamin D were evaluated. Results: D treatment has significantly improved hyperglycemia, hyperinsulinemia, and insulin sensitivity compared with the non-treated diabeticrats. Oral administration of vitamin D in streptozotocin-induced T2DM reduced blood sugar levels, increased insulin levels (more prominently when administered along with glimepiride) and decreased HbA1c levels (p<0.005). Conclusions: Administration of vitamin D can improve hyperglycemia and hyperinsulinemia in streptozotocin-induced T2DM in rats. Thus, it could be considered as an add on therapy along with other antidiabetic drugs.