Murugaiyan Vasanthi1, Prashant Shankarrao Adole1, Vinay Ramakrishna Pandit2, Kolar Vishwanath Vinod3. 1. Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Department of Biochemistry, Pondicherry, India. 2. Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Department of Emergency Medicine and Trauma, Pondicherry, India. 3. Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Department of Medicine, Pondicherry, India.
Abstract
BACKGROUND: High prevalence of type 2 diabetes mellitus (T2DM) is associated with a higher prevalence of acute coronary syndrome (ACS). Inflammation is one of the important contributors to the pathogenesis and complications of coronary atherosclerotic plaque. Growth Differentiation Factor-15 (GDF-15) and Tenascin-C (TNC) play an important role in the initiation of atherosclerotic plaque as well as its rupture. The aim of the study was to evaluate the association between serum GDF-15, TNC, and the risk of ACS among T2DM patients. METHODS: Anthropometric parameters, routine biochemical investigations like liver and renal function tests, lipid profile, and Creatine Kinase-Total (CK-T), Creatine Kinase-MB (CK-MB) were measured in 42 T2DM patients with ACS and 42 T2DM patients. Serum GDF-15 and TNC were measured by Human Sandwich-ELISA kits. RESULTS: Serum GDF-15 and TNC levels were significantly higher in T2DM patients with ACS as compared to T2DM patients. Serum GDF-15 was significantly correlated with waist circumference, diastolic blood pressure, pulse, serum CK-T, and CK-MB. Serum TNC was significantly correlated with the pulse, serum CK-T, CK-MB, high-density lipoprotein-cholesterol, and blood urea nitro GEN. Multivariate linear regression analysis showed that waist circumference was independently positively associated with serum GDF-15. CONCLUSIONS: T2DM patients with higher serum GDF-15 and TNC levels were at higher risk of acute coronary syndrome independent of other cardiovascular risk factors. 2020 Murugaiyan Vasanthi, Prashant Shankarrao Adole, Vinay Ramakrishna Pandit, Kolar Vishwanath Vinod, published by CEON/CEES.
BACKGROUND: High prevalence of type 2 diabetes mellitus (T2DM) is associated with a higher prevalence of acute coronary syndrome (ACS). Inflammation is one of the important contributors to the pathogenesis and complications of coronary atherosclerotic plaque. Growth Differentiation Factor-15 (GDF-15) and Tenascin-C (TNC) play an important role in the initiation of atherosclerotic plaque as well as its rupture. The aim of the study was to evaluate the association between serum GDF-15, TNC, and the risk of ACS among T2DM patients. METHODS: Anthropometric parameters, routine biochemical investigations like liver and renal function tests, lipid profile, and Creatine Kinase-Total (CK-T), Creatine Kinase-MB (CK-MB) were measured in 42 T2DM patients with ACS and 42 T2DM patients. Serum GDF-15 and TNC were measured by Human Sandwich-ELISA kits. RESULTS: Serum GDF-15 and TNC levels were significantly higher in T2DM patients with ACS as compared to T2DM patients. Serum GDF-15 was significantly correlated with waist circumference, diastolic blood pressure, pulse, serum CK-T, and CK-MB. Serum TNC was significantly correlated with the pulse, serum CK-T, CK-MB, high-density lipoprotein-cholesterol, and blood urea nitro GEN. Multivariate linear regression analysis showed that waist circumference was independently positively associated with serum GDF-15. CONCLUSIONS: T2DM patients with higher serum GDF-15 and TNC levels were at higher risk of acute coronary syndrome independent of other cardiovascular risk factors. 2020 Murugaiyan Vasanthi, Prashant Shankarrao Adole, Vinay Ramakrishna Pandit, Kolar Vishwanath Vinod, published by CEON/CEES.
Authors: Lars Lind; Lars Wallentin; Tibor Kempf; Heike Tapken; Anja Quint; Bertil Lindahl; Sylvia Olofsson; Per Venge; Anders Larsson; Johannes Hulthe; Anders Elmgren; Kai C Wollert Journal: Eur Heart J Date: 2009-06-26 Impact factor: 29.983