| Literature DB >> 33311501 |
Jemma L Geoghegan1,2, Xiaoyun Ren3, Matthew Storey3, James Hadfield4, Lauren Jelley3, Sarah Jefferies3, Jill Sherwood3, Shevaun Paine3, Sue Huang3, Jordan Douglas5, Fábio K Mendes5, Andrew Sporle6,7, Michael G Baker8, David R Murdoch9, Nigel French10, Colin R Simpson11,12, David Welch5, Alexei J Drummond5, Edward C Holmes13, Sebastián Duchêne14, Joep de Ligt3.
Abstract
New Zealand, a geographically remote Pacific island with easily sealable borders, implemented a nationwide 'lockdown' of all non-essential services to curb the spread of COVID-19. Here, we generate 649 SARS-CoV-2 genome sequences from infected patients in New Zealand with samples collected during the 'first wave', representing 56% of all confirmed cases in this time period. Despite its remoteness, the viruses imported into New Zealand represented nearly all of the genomic diversity sequenced from the global virus population. These data helped to quantify the effectiveness of public health interventions. For example, the effective reproductive number, Re of New Zealand's largest cluster decreased from 7 to 0.2 within the first week of lockdown. Similarly, only 19% of virus introductions into New Zealand resulted in ongoing transmission of more than one additional case. Overall, these results demonstrate the utility of genomic pathogen surveillance to inform public health and disease mitigation.Entities:
Year: 2020 PMID： 33311501 DOI： 10.1038/s41467-020-20235-8
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919