Zheng He1, Yinian Fang1, Qin Zuo1, Xiaoxing Huang2, Yongfang Lei1, Xiuhua Ren1, Dong Liu3. 1. Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. 2. Department of Blood Transfusion, Zhongnan Hospital of Wuhan University, Wuhan, China. 3. Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: l_d2069@163.com.
Abstract
OBJECTIVES: Coronavirus disease 2019 has now become a pandemic worldwide. However, the hazard to the newborn in pregnancy is still controversial. This study aims to investigate the vertical transmission of the virus from mother to child and its developmental toxicity in fetal. METHODS: All clinical information was recorded on 22 neonates born to the mother that was confirmed with coronavirus disease 2019 pneumonia in Tongji Hospital. RESULTS: The average birth weight of the 22 newborns (including 16 males and 6 females) was 2980 g, and the mean gestational week was 37W+3. Three babies' birth weight was lower than 2500g, the gestational week of all three low birth weight neonates was less than 36 W. Three newborns had minor lesions of infection in the lungs by Computed tomography scans. Furthermore, three newborns had elevated severe acute respiratory syndrome-related coronavirus-2 Ig (immunoglobin) M antibodies, and 11 newborns (52.4%) had positive IgG antibodies. Notably, both cystatin C and β2-microglobulin were increased in all newborns. Meanwhile, five of the 21 newborns had leukocytosis, and eleven newborns demonstrated increased neutrophil. Besides, the aspartate aminotransferase of 18 newborns and the γ-glutamyl transpeptidase of 19 newborns were increased. All the total bilirubin was elevated, and serum albumin in 90.9% of neonatal was reduced. CONCLUSIONS: This study first discovered the coronavirus disease 2019 infection in the third trimester could cause fetal kidney development injury, specific performance as increased cystatin C and β2-microglobulin in all neonates. Meanwhile, there is the possibility of the maternal-fetal transmission of the virus.
OBJECTIVES:Coronavirus disease 2019 has now become a pandemic worldwide. However, the hazard to the newborn in pregnancy is still controversial. This study aims to investigate the vertical transmission of the virus from mother to child and its developmental toxicity in fetal. METHODS: All clinical information was recorded on 22 neonates born to the mother that was confirmed with coronavirus disease 2019 pneumonia in Tongji Hospital. RESULTS: The average birth weight of the 22 newborns (including 16 males and 6 females) was 2980 g, and the mean gestational week was 37W+3. Three babies' birth weight was lower than 2500g, the gestational week of all three low birth weight neonates was less than 36 W. Three newborns had minor lesions of infection in the lungs by Computed tomography scans. Furthermore, three newborns had elevated severe acute respiratory syndrome-related coronavirus-2 Ig (immunoglobin) M antibodies, and 11 newborns (52.4%) had positive IgG antibodies. Notably, both cystatin C and β2-microglobulin were increased in all newborns. Meanwhile, five of the 21 newborns had leukocytosis, and eleven newborns demonstrated increased neutrophil. Besides, the aspartate aminotransferase of 18 newborns and the γ-glutamyl transpeptidase of 19 newborns were increased. All the total bilirubin was elevated, and serum albumin in 90.9% of neonatal was reduced. CONCLUSIONS: This study first discovered the coronavirus disease 2019infection in the third trimester could cause fetal kidney development injury, specific performance as increased cystatin C and β2-microglobulin in all neonates. Meanwhile, there is the possibility of the maternal-fetal transmission of the virus.