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Literature DB >> 3330789

A new anti-p53 monoclonal antibody, previously reported to be directed against the large T antigen of simian virus 40.

Abstract

The PAb1620 antibody belongs to a group of monoclonal antibodies reported to recognize nuclear large T antigen of simian virus 40 (SV40). In the case of PAb1620 there was some indication that the antibody reacted preferentially with large T when it was complexed with p53, the cellular transformation-related antigen. However, we found that PAb1620 does not appear to react with SV40 large T, either free or in complex with p53. In this paper we demonstrate that PAb1620 is, in fact, directed against the p53 protein and recognizes a conformation-dependent epitope. In addition, PAb1620 recognises human p53 from SV80 cells.

Entities: Chemical Gene Species

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Year: 1987 PMID： 3330789

Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867

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Cited

30 in total

1. Repression of the basal c-fos promoter by wild-type p53.

Authors: N Kley; R Y Chung; S Fay; J P Loeffler; B R Seizinger
Journal: Nucleic Acids Res Date: 1992-08-11 Impact factor: 16.971

2. Mammalian p53 can function as a transcription factor in yeast.

Authors: E Schärer; R Iggo
Journal: Nucleic Acids Res Date: 1992-04-11 Impact factor: 16.971

3. Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

Authors: J Milner; E A Medcalf; A C Cook
Journal: Mol Cell Biol Date: 1991-01 Impact factor: 4.272

4. Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids.

Authors: L Wu; J H Bayle; B Elenbaas; N P Pavletich; A J Levine
Journal: Mol Cell Biol Date: 1995-01 Impact factor: 4.272

A new anti-p53 monoclonal antibody, previously reported to be directed against the large T antigen of simian virus 40.

1. Repression of the basal c-fos promoter by wild-type p53.

2. Mammalian p53 can function as a transcription factor in yeast.

3. Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

4. Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids.

5. p53 DNA binding can be modulated by factors that alter the conformational equilibrium.

6. Detection of p53 in inflammatory tissue and lymphocytes using immunohistology and flow cytometry: a critical comment.

7. Isg15 controls p53 stability and functions.

8. Evidence for allosteric effects on p53 oligomerization induced by phosphorylation.

9. Inhibition of p53 DNA binding by human papillomavirus E6 proteins.

Review 10. Awakening guardian angels: drugging the p53 pathway.