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Literature DB >> 33307802

Functional intrinsic optical signal imaging for objective optoretinography of human photoreceptors.

Taeyoon Son¹, Tae-Hoon Kim¹, Guangying Ma¹, Hoonsup Kim¹, Xincheng Yao^1,2.

Abstract

Functional mapping of photoreceptor physiology is important for better disease diagnosis and treatment assessment. Fast intrinsic optical signal (IOS), which arises before light-evoked pupillary response, promises a unique biomarker of photoreceptor physiology for objective optoretinography with high resolution. This study is to test the feasibility of non-mydriatic IOS mapping of retinal photoreceptors in awake human. Depth-resolved optical coherence tomography verified outer segment (OS) as the anatomic origin of fast photoreceptor-IOS. Dynamic IOS changes are primarily confined at OS boundaries connected with inner segment and retinal pigment epithelium, supporting transient OS shrinkage due to phototransduction process as the mechanism of the fast photoreceptor-IOS response.

Entities: Chemical

Keywords: Intrinsic optical signal; optical coherence tomography; optophysiology; optoretinography; photoreceptor; retina

Mesh：

Year: 2020 PMID： 33307802 PMCID： PMC7988726 DOI： 10.1177/1535370220978898

Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699

41 in total

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5 in total

1. Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system.

Authors: Ewelina Pijewska; Pengfei Zhang; Michał Meina; Ratheesh K Meleppat; Maciej Szkulmowski; Robert J Zawadzki
Journal: Biomed Opt Express Date: 2021-11-30 Impact factor: 3.562

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Authors: Tae-Hoon Kim; Guangying Ma; Taeyoon Son; Xincheng Yao
Journal: Front Med (Lausanne) Date: 2022-04-04