Literature DB >> 3330780

Human oncogenes detected by a defined medium culture assay.

X Zhan1, A Culpepper, M Reddy, J Loveless, M Goldfarb.   

Abstract

Oncogenes in DNAs from human tumor cell lines have been detected by a new transformation assay. Cellular DNAs are transfected into NIH3T3 murine fibroblasts, and transformed cells are selected by maintaining cell cultures in a defined medium lacking platelet-derived or fibroblast growth factors. DNAs from eight of 17 human tumor cell lines have yielded transformants by this method. Activated cellular ras genes account for three of the transforming activities. The SAOS2 osteosarcoma cell line contains an activated oncogene distinct from 18 known oncogenes. Another cellular oncogene was detected as the consequence of a fortuitous transfection-mediated DNA rearrangement.

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Year:  1987        PMID： 3330780

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  15 in total

1.  Detection and characterization of the fibroblast growth factor-related oncoprotein INT-2.

Authors:  M Dixon; R Deed; P Acland; R Moore; A Whyte; G Peters; C Dickson
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

2.  The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

Authors:  X Zhan; B Bates; X G Hu; M Goldfarb
Journal:  Mol Cell Biol       Date:  1988-08       Impact factor: 4.272

3.  Biosynthesis of human fibroblast growth factor-5.

Authors:  B Bates; J Hardin; X Zhan; K Drickamer; M Goldfarb
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

4.  Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system.

Authors:  O Haub; B Drucker; M Goldfarb
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

5.  Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic cats.

Authors:  James S Kehler; Victor A David; Alejandro A Schäffer; Kristina Bajema; Eduardo Eizirik; David K Ryugo; Steven S Hannah; Stephen J O'Brien; Marilyn Menotti-Raymond
Journal:  J Hered       Date:  2007-09-01       Impact factor: 2.645

6.  Retention of fibroblast growth factor 3 in the Golgi complex may regulate its export from cells.

Authors:  P Kiefer; G Peters; C Dickson
Journal:  Mol Cell Biol       Date:  1993-09       Impact factor: 4.272

7.  The Int-2/Fgf-3 oncogene product is secreted and associates with extracellular matrix: implications for cell transformation.

Authors:  P Kiefer; G Peters; C Dickson
Journal:  Mol Cell Biol       Date:  1991-12       Impact factor: 4.272

8.  Fibroblast growth factor gene expression in AIDS-Kaposi's sarcoma detected by in situ hybridization.

Authors:  L Xerri; J Hassoun; J Planche; V Guigou; J J Grob; P Parc; D Birnbaum; O deLapeyriere
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307

9.  Fibroblast growth factor receptors have different signaling and mitogenic potentials.

Authors:  J K Wang; G Gao; M Goldfarb
Journal:  Mol Cell Biol       Date:  1994-01       Impact factor: 4.272

10.  Enhanced fibroblast growth factor 5 expression in stromal and exocrine elements of the pancreas in chronic pancreatitis.

Authors:  T Ishiwata; M Kornmann; H G Beger; M Korc
Journal:  Gut       Date:  1998-07       Impact factor: 23.059
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