| Literature DB >> 33307047 |
Yu Mimura1, Hana Nishida1, Shinichiro Nakajima2, Sakiko Tsugawa1, Shinji Morita1, Kazunari Yoshida3, Ryosuke Tarumi1, Kamiyu Ogyu1, Masataka Wada1, Shin Kurose1, Takahiro Miyazaki1, Daniel M Blumberger4, Zafiris J Daskalakis4, Robert Chen5, Masaru Mimura1, Yoshihiro Noda6.
Abstract
Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological tool that enables the investigation of cortical excitability in the human brain. Paired-pulse TMS paradigms include short- and long-interval intracortical inhibition (SICI/LICI), intracortical facilitation (ICF), and short-latency afferent inhibition (SAI), which can assess neurophysiological functions of GABAergic, glutamatergic, and cholinergic neural circuits, respectively. We conducted the first systematic review and meta-analysis to compare these TMS indices among patients with AD, mild cognitive impairment (MCI), and healthy controls (HC). Our meta-analyses indicated that RMT, SAI, SICI, and LICI were significantly lower in patients with AD, while ICF did not show a difference in patients with AD compared with HC. In patients with MCI, RMT and SAI were significantly lower than in HC. In conclusion, motor cortical excitability was increased, while cholinergic function was decreased in AD and MCI in comparison with HC and patients with AD had decreased GABAergic and glutamatergic functions compared with HC. Our results warrant further studies to differentiate AD, MCI, and HC, employing multimodal TMS neurophysiology.Entities:
Keywords: Alzheimer’s disease; Biomarker; ICF; LICI; Mild cognitive impairment; PAS; Plasticity; RMT; SAI; SICI; TMS
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Year: 2020 PMID： 33307047 DOI： 10.1016/j.neubiorev.2020.12.003
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989