Yihienew M Bezabih1, Wilber Sabiiti2, Endalkachew Alamneh3, Alamneh Bezabih4, Gregory M Peterson3, Woldesellassie M Bezabhe3, Anna Roujeinikova5. 1. Arsi University College of Health Sciences, Arsi University, PO Box 0193, Asella, Ethiopia. 2. School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK. 3. School of Pharmacy and Pharmacology, University of Tasmania, Australia. 4. École nationale vétérinaire, agroalimentaire et de l'alimentation, Nantes-Atlantique, BIOEPAR (UMR1300 INRA/ONIRIS), Nantes, France. 5. Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Abstract
OBJECTIVES: Intestinal colonization by ESBL Escherichia coli and its association with community-acquired MDR infections is of great concern. This review determined the worldwide prevalence of human faecal ESBL E. coli carriage and its trend in the community over the past two decades. METHODS: A systematic literature search was conducted using PubMed, EMBASE and Google Scholar to retrieve articles published between 1 January 2000 and 13 February 2020 that contained data on the prevalence of faecal carriage of ESBL E. coli among healthy individuals. A cumulative (for the whole period) meta-analysis was used to estimate the global and regional pooled prevalence rates. Articles were grouped into study periods of 3 years, and subgroup meta-analyses were undertaken to examine the global pooled prevalence over time. RESULTS: Sixty-two articles covering 29 872 healthy persons were included in this meta-analysis. The cumulative (2003-18) global pooled prevalence of ESBL E. coli intestinal carriage in the community was 16.5% (95% CI 14.3%-18.7%; P < 0.001). The pooled prevalence showed an upward trend, increasing from 2.6% (95% CI 1.6%-4.0%) in 2003-05 to 21.1% (95% CI 15.8%-27.0%) in 2015-18. Over the whole period, the highest carriage rate was observed in South-East Asia (27%; 95% CI 2.9%-51.3%), while the lowest occurred in Europe (6.0%; 95% CI 4.6%-7.5%). CONCLUSIONS: Globally, an 8-fold increase in the intestinal carriage rate of ESBL E. coli in the community has occurred over the past two decades. Prevention of its spread may require new therapeutic and public health strategies.
OBJECTIVES: Intestinal colonization by ESBLEscherichia coli and its association with community-acquired MDR infections is of great concern. This review determined the worldwide prevalence of human faecal ESBLE. coli carriage and its trend in the community over the past two decades. METHODS: A systematic literature search was conducted using PubMed, EMBASE and Google Scholar to retrieve articles published between 1 January 2000 and 13 February 2020 that contained data on the prevalence of faecal carriage of ESBLE. coli among healthy individuals. A cumulative (for the whole period) meta-analysis was used to estimate the global and regional pooled prevalence rates. Articles were grouped into study periods of 3 years, and subgroup meta-analyses were undertaken to examine the global pooled prevalence over time. RESULTS: Sixty-two articles covering 29 872 healthy persons were included in this meta-analysis. The cumulative (2003-18) global pooled prevalence of ESBLE. coli intestinal carriage in the community was 16.5% (95% CI 14.3%-18.7%; P < 0.001). The pooled prevalence showed an upward trend, increasing from 2.6% (95% CI 1.6%-4.0%) in 2003-05 to 21.1% (95% CI 15.8%-27.0%) in 2015-18. Over the whole period, the highest carriage rate was observed in South-East Asia (27%; 95% CI 2.9%-51.3%), while the lowest occurred in Europe (6.0%; 95% CI 4.6%-7.5%). CONCLUSIONS: Globally, an 8-fold increase in the intestinal carriage rate of ESBLE. coli in the community has occurred over the past two decades. Prevention of its spread may require new therapeutic and public health strategies.
Authors: M Gholami-Ahangaran; A H Moravvej; Z Safizadeh; V Sadeghi Nogoorani; M Zokaei; S O Ghasemian Journal: Iran J Vet Res Date: 2021 Impact factor: 1.376
Authors: Timothy J Johnson; Meggan E Craft; Katherine E L Worsley-Tonks; Stanley D Gehrt; Elizabeth A Miller; Randall S Singer; Jeff B Bender; James D Forester; Shane C McKenzie; Dominic A Travis Journal: Appl Environ Microbiol Date: 2021-07-13 Impact factor: 4.792
Authors: Jade L L Teng; Ruibang Luo; Bone S F Tang; Jordan Y H Fong; Li Wang; Lilong Jia; Chloe K S Wong; Elaine Chan; Amy W S Leung; Gilman K H Siu; Tsz-Ho Chiu; Ami M Y Fung; Alan K L Wu; Man-Lung Yeung; Susanna K P Lau; Patrick C Y Woo Journal: Front Microbiol Date: 2021-02-09 Impact factor: 5.640
Authors: David A Singleton; Pisut Pongchaikul; Shirley Smith; Rebecca J Bengtsson; Kate Baker; Dorina Timofte; Stephen Steen; Matthew Jones; Larry Roberts; Fernando Sánchez-Vizcaíno; Susan Dawson; P-J M Noble; Alan D Radford; Gina L Pinchbeck; Nicola J Williams Journal: Front Microbiol Date: 2021-07-30 Impact factor: 5.640
Authors: Bayaraa Baljin; Ulziijargal Gurjav; Khosbayar Tulgaa; Ganbaatar Baldan; Batbaatar Gunchin; Tsogtsaikhan Sandag; Klaus Pfeffer; Andreas F Wendel; Colin R MacKenzie Journal: Infect Drug Resist Date: 2021-09-23 Impact factor: 4.003
Authors: Yuk Kam Yau; Wing Yan Joyce Mak; Nok Shun Rashid Lui; Wai Yin Rita Ng; Choi Yan Kitty Cheung; Ying Lee Amy Li; Yuet Ling Jessica Ching; Miu Ling Chin; Ho Shing Louis Lau; Ka Leung Francis Chan; Kay Sheung Paul Chan; Siew Chien Ng Journal: United European Gastroenterol J Date: 2021-10-08 Impact factor: 4.623