Atsuro Sawada1, Shusuke Hiragi2, Hiroshi Tamura3, Rei Goto4, Yoko Matsuyama5, Kaoru Sakai6, Hitomi Miyata6, Motoko Yanagita6, Tomohiro Kuroda3, Osamu Ogawa7, Takashi Kobayashi1. 1. Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan. 2. Division of Medical Informatics and Administration Planning, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan. 3. Division of Medical Informatics and Administration Planning, Kyoto University Graduate School of Medicine, Kyoto, Japan. 4. Graduate School of Business Administration, Keio University, Tokyo, Japan. 5. Department of Nursing, Kyoto University Graduate School of Medicine, Kyoto, Japan. 6. Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan. 7. Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: ogawao@kuhp.kyoto-u.ac.jp.
Abstract
BACKGROUND: Renal transplantation improves the quality of life (QOL) of end-stage renal disease (ESRD) patients with renal failure. However, it remains unclear which renal disease-specific QOL aspects determine general health-related QOL of ESRD patients. This study aimed to identify these QOL items by examining the QOL of ESRD patients using the Kidney Disease Quality of Life-Short Form (KDQOL-SF), version 1.3, and EuroQoL-5 dimension-5 levels (EQ-5D-5L) questionnaires. METHODS: We conducted QOL surveys with 67 renal transplant recipients at our hospital. EQ-5D-5L, which evaluates general health-related QOL, was the response variable, and KDQOL-SF, which includes the renal disease-specific instrument and general health-related QOL SF-36 instrument, was the explanatory variable. We analyzed the effects of each KDQOL-SF domain on EQ-5D-5L using Pearson correlation coefficient. RESULTS: Regarding the general health-related QOL assessed by SF-36, physical health aspects, such as physical functioning (R = 0.749) and daily functioning physical (R = 0.603), showed a strong correlation with EQ-5D-5L, and the domains related to the psychological and social aspects of QOL showed a limited correlation. Regarding kidney disease-specific scales, symptoms/problems related to physical function showed a good correlation (R = 0.691) with EQ-5D-5L, whereas other scales, including burden of kidney disease (R = 0.168), quality of social interaction (R = 0.284), and those related to the mental and social aspects of QOL showed a low correlation with EQ-5D-5L. CONCLUSION: Among kidney transplant recipients, the physical health aspects of QOL, such as symptoms/problems, were the major factors influencing overall QOL as assessed by EQ-5D-5L.
BACKGROUND: Renal transplantation improves the quality of life (QOL) of end-stage renal disease (ESRD) patients with renal failure. However, it remains unclear which renal disease-specific QOL aspects determine general health-related QOL of ESRDpatients. This study aimed to identify these QOL items by examining the QOL of ESRDpatients using the Kidney Disease Quality of Life-Short Form (KDQOL-SF), version 1.3, and EuroQoL-5 dimension-5 levels (EQ-5D-5L) questionnaires. METHODS: We conducted QOL surveys with 67 renal transplant recipients at our hospital. EQ-5D-5L, which evaluates general health-related QOL, was the response variable, and KDQOL-SF, which includes the renal disease-specific instrument and general health-related QOL SF-36 instrument, was the explanatory variable. We analyzed the effects of each KDQOL-SF domain on EQ-5D-5L using Pearson correlation coefficient. RESULTS: Regarding the general health-related QOL assessed by SF-36, physical health aspects, such as physical functioning (R = 0.749) and daily functioning physical (R = 0.603), showed a strong correlation with EQ-5D-5L, and the domains related to the psychological and social aspects of QOL showed a limited correlation. Regarding kidney disease-specific scales, symptoms/problems related to physical function showed a good correlation (R = 0.691) with EQ-5D-5L, whereas other scales, including burden of kidney disease (R = 0.168), quality of social interaction (R = 0.284), and those related to the mental and social aspects of QOL showed a low correlation with EQ-5D-5L. CONCLUSION: Among kidney transplant recipients, the physical health aspects of QOL, such as symptoms/problems, were the major factors influencing overall QOL as assessed by EQ-5D-5L.