Literature DB >> 33302474

Application of Hydroxytyrosol in the Functional Foods Field: From Ingredient to Dietary Supplements.

Andreia F R Silva1, Daniela Resende1, Mariana Monteiro1, Manuel A Coimbra1, Artur M S Silva1, Susana M Cardoso1.   

Abstract

Hydroxytyrosol (HT) is an amphipathic functional phenol found in the olive tree, both in its leaves and fruits, in free or bound forms, as well as in olive oil and by-products of olive oil manufacture. The European Food Safety Authority recommends regular consumption of HT due to its several beneficial effects on human health, which are closely associated to its antioxidant activity. These reasons make HT an excellent candidate for application as a functional ingredient in the design of novel food products. Patents already exist for methodologies of extraction, purification, and application of HT in supplements and food products. The present review discusses the impact of HT incorporation on food properties and its effects on consumers, based on relevant data related to the use of HT as a functional ingredient, both as a pure compound or in the form of HT-rich extracts, in various food products, namely in edible oils, beverages, bakery products, as well animal-based foods such as meat, fishery and dairy products.

Entities:  

Keywords:  antioxidant; by-products; functional ingredient; novel foods; olive oil; phenol; table olives

Year:  2020        PMID: 33302474      PMCID: PMC7763879          DOI: 10.3390/antiox9121246

Source DB:  PubMed          Journal:  Antioxidants (Basel)        ISSN: 2076-3921


  86 in total

1.  Protective effects of hydroxytyrosol on liver ischemia/reperfusion injury in mice.

Authors:  Shangha Pan; Lianxin Liu; Huayang Pan; Yong Ma; Dawei Wang; Kai Kang; Jizhou Wang; Bei Sun; Xueying Sun; Hongchi Jiang
Journal:  Mol Nutr Food Res       Date:  2013-05-07       Impact factor: 5.914

2.  One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development.

Authors:  M González-Santiago; E Martín-Bautista; J J Carrero; J Fonollá; L Baró; M V Bartolomé; P Gil-Loyzaga; E López-Huertas
Journal:  Atherosclerosis       Date:  2005-11-18       Impact factor: 5.162

3.  Chronic hydroxytyrosol feeding modulates glutathione-mediated oxido-reduction pathways in adipose tissue: a nutrigenomic study.

Authors:  E Giordano; A Dávalos; F Visioli
Journal:  Nutr Metab Cardiovasc Dis       Date:  2014-05-28       Impact factor: 4.222

4.  Species and strain differences in the butylated hydroxytoluene (BHT)-producing induction of hepatic drug oxidation enzymes.

Authors:  S Kawano; T Nakao; K Hiraga
Journal:  Jpn J Pharmacol       Date:  1980-12

5.  Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H(2)O(2) induced lipid peroxidation in renal tubular epithelial cells.

Authors:  Monica Deiana; Alessandra Incani; Antonella Rosa; Giulia Corona; Angela Atzeri; Debora Loru; M Paola Melis; M Assunta Dessì
Journal:  Food Chem Toxicol       Date:  2008-06-07       Impact factor: 6.023

6.  Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils.

Authors:  Yvonne O'Dowd; Fathi Driss; Pham My-Chan Dang; Carole Elbim; Marie-Anne Gougerot-Pocidalo; Catherine Pasquier; Jamel El-Benna
Journal:  Biochem Pharmacol       Date:  2004-11-15       Impact factor: 5.858

7.  Hydroxytyrosol prevents oxidative deterioration in foodstuffs rich in fish lipids.

Authors:  Manuel Pazos; Ana Alonso; Isabel Sánchez; Isabel Medina
Journal:  J Agric Food Chem       Date:  2008-04-22       Impact factor: 5.279

8.  Hydroxytyrosol in functional hydroxytyrosol-enriched biscuits is highly bioavailable and decreases oxidised low density lipoprotein levels in humans.

Authors:  Raquel Mateos; Sara Martínez-López; Gema Baeza Arévalo; Miryam Amigo-Benavent; Beatriz Sarriá; Laura Bravo-Clemente
Journal:  Food Chem       Date:  2016-03-04       Impact factor: 7.514

Review 9.  Hydroxytyrosol and Cytoprotection: A Projection for Clinical Interventions.

Authors:  Francisca Echeverría; Macarena Ortiz; Rodrigo Valenzuela; Luis A Videla
Journal:  Int J Mol Sci       Date:  2017-04-28       Impact factor: 5.923

Review 10.  Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence.

Authors:  Filip Vlavcheski; Mariah Young; Evangelia Tsiani
Journal:  Antioxidants (Basel)       Date:  2019-06-21
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  5 in total

1.  Thermo-Responsive Gel Containing Hydroxytyrosol-Chitosan Nanoparticles (Hyt@tgel) Counteracts the Increase of Osteoarthritis Biomarkers in Human Chondrocytes.

Authors:  Anna Valentino; Raffaele Conte; Ilenia De Luca; Francesca Di Cristo; Gianfranco Peluso; Michela Bosetti; Anna Calarco
Journal:  Antioxidants (Basel)       Date:  2022-06-20

Review 2.  Progress in Colloid Delivery Systems for Protection and Delivery of Phenolic Bioactive Compounds: Two Study Cases-Hydroxytyrosol and Curcumin.

Authors:  Francesca Cuomo; Silvio Iacovino; Pasquale Sacco; Antonella De Leonardis; Andrea Ceglie; Francesco Lopez
Journal:  Molecules       Date:  2022-01-29       Impact factor: 4.411

3.  Hidrox® Counteracts Cyclophosphamide-Induced Male Infertility through NRF2 Pathways in a Mouse Model.

Authors:  Roberta Fusco; Angela Trovato Salinaro; Rosalba Siracusa; Ramona D'Amico; Daniela Impellizzeri; Maria Scuto; Maria Laura Ontario; Roberto Crea; Marika Cordaro; Salvatore Cuzzocrea; Rosanna Di Paola; Vittorio Calabrese
Journal:  Antioxidants (Basel)       Date:  2021-05-14

Review 4.  Strategies to Broaden the Applications of Olive Biophenols Oleuropein and Hydroxytyrosol in Food Products.

Authors:  Mariana Monteiro; Andreia F R Silva; Daniela Resende; Susana S Braga; Manuel A Coimbra; Artur M S Silva; Susana M Cardoso
Journal:  Antioxidants (Basel)       Date:  2021-03-13

5.  Synergistic Effect of 3',4'-Dihidroxifenilglicol and Hydroxytyrosol on Oxidative and Nitrosative Stress and Some Cardiovascular Biomarkers in an Experimental Model of Type 1 Diabetes Mellitus.

Authors:  José Pedro De La Cruz Cortés; Leticia Vallejo-Carmona; María Monsalud Arrebola; Esther Martín-Aurioles; María Dolores Rodriguez-Pérez; Laura Ortega-Hombrados; Cristina Verdugo; María África Fernández-Prior; Alejandra Bermúdez-Oria; José Antonio González-Correa
Journal:  Antioxidants (Basel)       Date:  2021-12-13
  5 in total

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